Short regulatory DNA sequences to target brain endothelial cells for gene therapy

Short regulatory DNA sequences to target brain endothelial cells for gene therapy

Gene vectors focusing on CNS endothelial cells enable to govern the blood-brain barrier and to right genetic defects within the CNS. As a result of vectors based mostly on the adeno-associated virus (AAV) have a restricted capability, it’s important that the DNA sequence controlling gene expression is brief. As well as, it should be particular for endothelial cells to keep away from off-target results.
To develop improved regulatory sequences with selectivity for mind endothelial cells, we examined the transcriptional exercise of truncated promoters of 11 (mind) endothelial-specific genes together with quick regulatory parts, i.e., the woodchuck post-transcriptional regulatory ingredient (W), the CMV enhancer ingredient (C), and a fraction of the primary intron of the Tie2 gene (S), by transfecting mind endothelial cells of three species.
4 mixtures of regulatory parts and quick promoters (Cdh5OclnSlc2a1, and Slco1c1) progressed by means of this in-vitro pipeline displaying appropriate exercise. When examined in mice, the regulatory sequences C-Ocln-W and C-Slc2a1-S-W enabled a stronger and extra particular gene expression in mind endothelial cells than the steadily used CAG promoter. In abstract, the brand new regulatory parts effectively management gene expression in mind endothelial cells and should assist to particularly goal the blood-brain barrier with gene remedy vectors.

From Pancreatic βCell Gene Networks to Novel Therapies for Kind 1 Diabetes

Completion of the Human Genome Mission enabled a novel systems- and network-level understanding of biology, however this stays to be utilized for understanding the pathogenesis of sort 1 diabetes (T1D). We suggest that defining the important thing gene regulatory networks that drive β-cell dysfunction and loss of life in T1D would possibly allow the design of therapies that focus on the core illness mechanism, specifically, the progressive lack of pancreatic β-cells.
Certainly, many profitable medicine don’t immediately goal particular person illness genes however, moderately, modulate the implications of faulty steps, focusing on proteins positioned one or two steps downstream. If we transpose this to the T1D scenario, it is smart to focus on the pathways that modulate the β-cell responses to the immune assault-in relation to indicators which will stimulate the immune response (e.g., HLA class I and chemokine overexpression and/or neoantigen expression) or inhibit the invading immune cells (e.g., PDL1 and HLA-E expression)-instead of focusing on solely the immune system, as it’s normally proposed.
Short regulatory DNA sequences to target brain endothelial cells for gene therapy
Right here we talk about the significance of a give attention to β-cells in T1D, classes realized from different autoimmune illnesses, the “different splicing connection,” information mining, and drug repurposing to guard β-cells in T1D after which among the preliminary candidates below testing for β-cell safety.

Danger evaluation of leachables in cell and gene remedy utilizing a CAR-T mannequin course of

With the quickly rising subject of autologous therapies, Single-Use (SU) applied sciences are more and more utilized in personalised medication resulting from their manifold benefits. Though qualification of the beginning materials of autologous therapies such because the CAR-T course of has been highlighted, little consideration has been paid to the impact of leachables on cell-based therapies, even when latest research point out interactions of leachables with cells.
To shut this hole, this examine presents a risk-analysis of SU-material on a CAR-T course of and identifies hazards imposed by tubing supplies and leachables thereof. With a purpose to symbolize a CAR-T course of in its entirety, two check programs, specifically a lentivirus manufacturing course of and first T-cells, had been used. Whereas the results on lentivirus manufacturing are similar to these reported for antibody manufacturing processes in CHO cells, we discovered that PVC materials and corresponding leachables, i.e. plasticizer, inhibit cell development of main T-cells to a fantastic extent. Moreover, our outcomes point out that important high quality attributes are affected by the PVC materials.

Engineering genetic units for in vivo management of therapeutic T cell exercise triggered by the dietary molecule resveratrol

Chimeric antigen receptor (CAR)-engineered T cell therapies have been acknowledged as highly effective methods in most cancers immunotherapy; nevertheless, the scientific software of CAR-T is at present constrained by extreme opposed results in sufferers, brought on by extreme cytotoxic exercise and poor T cell management. Herein, we harnessed a dietary molecule resveratrol (RES)-responsive transactivator and a transrepressor to develop a repressible transgene expression (RESrep) gadget and an inducible transgene expression (RESind) gadget, respectively.
After optimization, these instruments enabled the management of CAR expression and CAR-mediated antitumor operate in engineered human cells. We demonstrated {that a} resveratrol-repressible CAR expression (RESrep-CAR) gadget can successfully inhibit T cell activation upon resveratrol administration in main T cells and a xenograft tumor mouse mannequin.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx411874-01mg 0.1 mg
EUR 644.4

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx411875-01mg 0.1 mg
EUR 661.2

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx412054-01mg 0.1 mg
EUR 844.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415204-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415206-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx415211-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx415213-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415215-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415216-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx433377-200ul 200 ul
EUR 460.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx411874-100g 100 µg
EUR 437.5

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx411875-100tests 100 tests
EUR 450

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx433377-100g 100 µg
EUR 387.5

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx375362-96tests 96 tests
EUR 337.5

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody

abx415206-200l 200 µl
EUR 337.5

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415216-200l 200 µl
EUR 337.5

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

AP76176 1mg
EUR 2369

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

AP76258 1mg
EUR 2649

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-10ug 10ug
EUR 132
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (PE)

abx415207-200l 200 µl
EUR 487.5

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (RPE)

abx415207-100tests 100 tests
EUR 710.4

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE)

abx415214-100tests 100 tests
EUR 710.4

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC)

abx415205-01mg 0.1 mg
EUR 610.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC)

abx415212-01mg 0.1 mg
EUR 610.8

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC)

abx415205-200l 200 µl
EUR 400

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

32146-05111 150 ug
EUR 215

Timd2 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2)

MG204271 10 µg Ask for price

Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (TIMD2) ELISA Kit

abx549772-96tests 96 tests
EUR 687.5

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

abx692171-100g 100 µg
EUR 837.5

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

abx692171-1mg 1 mg Ask for price

T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody

abx415208-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody

abx415210-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody

abx415210-200l 200 µl
EUR 337.5

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU11802-48T 48T
EUR 571.55

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU11802-5x96T 5x96T
EUR 3878.38

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU11802-96T 96T
EUR 816.5

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN52913-48T 48T
EUR 355.6

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN52913-5x96T 5x96T
EUR 2413

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN52913-96T 96T
EUR 508

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

abx549775-96tests 96 tests
EUR 687.5

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

AP75076 1mg
EUR 3209

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Timd4 (untagged) - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4), (10ug)

MC214328 10 µg Ask for price

Mouse Timd4 / T-cell immunoglobulin and mucin domain-containing protein 4 ELISA Kit

E13605m 96T
EUR 776

Human T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) ELISA Kit

SL3234Hu 96 Tests
EUR 468

Mouse Hepatitis A virus cellular receptor 2/T-cell immunoglobulin and mucin-domain containing-3 ELISA kit

E01A22718 96T
EUR 700
Description: ELISA

T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody (FITC)

abx415209-01mg 0.1 mg
EUR 610.8

T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody (FITC)

abx415209-200l 200 µl
EUR 412.5

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (Biotin Conjugate)

32146-05121 150 ug
EUR 315

Timd4 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4), (10ug)

MG222206 10 µg Ask for price

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody

20-abx174727
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  • 1 mg
  • 200 ug

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody

20-abx178542
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  • 1 mg
  • 200 ug

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody

abx174727-1ml 1 ml
EUR 787.5

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody

abx178542-96tests 96 tests
EUR 750

Timd4 (Myc-DDK-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4)

MR222206 10 µg Ask for price

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx031021-400ul 400 ul
EUR 627.6

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx031021-80l 80 µl
EUR 343.2

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

20-abx318087
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx031021-400l 400 µl
EUR 518.75

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx376033-96tests 96 tests
EUR 337.5

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx318087-100g 100 µg
EUR 362.5

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx318087-20g 20 µg
EUR 162.5

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx318087-50g 50 µg
EUR 250

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

AP75656 1mg
EUR 3209

Timd2 (untagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 2, (10ug)

MC201957 10 µg Ask for price

Rat T-cell immunoglobulin and mucin domain-containing protein 2 (TIMD2) ELISA Kit

abx549773-96tests 96 tests
EUR 687.5

Timd2 (Myc-DDK-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 2

MR204271 10 µg Ask for price

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (HRP)

20-abx316455
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (FITC)

20-abx316456
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (HRP)

abx316455-100g 100 µg
EUR 362.5

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (HRP)

abx316455-20g 20 µg
EUR 162.5

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (HRP)

abx316455-50g 50 µg
EUR 250

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (FITC)

abx316456-100g 100 µg
EUR 362.5

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (FITC)

abx316456-20g 20 µg
EUR 162.5

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (FITC)

abx316456-50g 50 µg
EUR 250

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 ELISA Kit

IHUTIMD4KT each
EUR 733
Description: Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 ELISA Kit

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

RPU56012-100ug 100ug
EUR 554.4

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

RPU56012-1mg 1mg
EUR 2184

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

RPU56012-50ug 50ug
EUR 336

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

RPH854Hu01 10ug
EUR 140

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

4-RPH854Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) expressed in: E.coli

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite™ Antibody (FITC Conjugate)

32146-05141 150 ug
EUR 370

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite™ Antibody (RPE Conjugate)

32146-05151 150 ug
EUR 370

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite™ Antibody (APC Conjugate)

32146-05161 150 ug
EUR 370

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (Biotin)

20-abx316457
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  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (Biotin)

abx316457-100g 100 µg
EUR 362.5

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (Biotin)

abx316457-20g 20 µg
EUR 162.5

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (Biotin)

abx316457-50g 50 µg
EUR 250

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite™ Antibody (PerCP Conjugate)

32146-05171 150 ug
EUR 410

Timd2 (Myc-DDK-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 3

MR218026 10 µg Ask for price

Timd2 (Myc-DDK-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2), transcript variant 1

MR216527 10 µg Ask for price

Timd2 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2) transcript variant 1, (10ug)

MG216527 10 µg Ask for price

Timd2 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2) transcript variant 3, (10ug)

MG218026 10 µg Ask for price

Timd2 (untagged ORF) - Rat T-cell immunoglobulin and mucin domain containing 2 (Timd2), (10 ug)

RN205453 10 µg Ask for price

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

20-abx655199
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

abx655199-10g 10 µg
EUR 200

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

abx655199-50g 50 µg
EUR 337.5

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) CLIA Kit

20-abx495562
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

ELISA Kit for T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

SEH854Hu 96Т
EUR 700

Lenti ORF clone of Timd4 (mGFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4)

MR222206L2 10 µg Ask for price

Lenti ORF clone of Timd4 (mGFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 4 (Timd4)

MR222206L4 10 µg Ask for price

Timd4 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 4 (cDNA clone MGC:41117 IMAGE:1195144)

MG205549 10 µg Ask for price

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

20-abx153299
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

DLR-TIMD4-Hu 96T
EUR 463
Description: tissue homogenates, cell lysates or other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

DLR-TIMD4-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates or other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

DLR-TIMD4-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates or other biological fluids.
Moreover, we exhibit how a resveratrol-inducible CAR expression (RESind-CAR) gadget can obtain fine-tuned and reversible management over T cell activation through a resveratrol-titratable mechanism. Moreover, our outcomes revealed that the presence of RES can activate RESind-CAR T cells with robust anticancer cytotoxicity towards cells in vitro and in vivo. Our examine demonstrates the utility of RESrep and RESind units as efficient instruments for transgene expression and illustrates the potential of RESrep-CAR and RESind-CAR units to boost affected person security in precision most cancers immunotherapies.

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