Gene vectors focusing on CNS endothelial cells enable to govern the blood-brain barrier and to right genetic defects within the CNS. As a result of vectors based mostly on the adeno-associated virus (AAV) have a restricted capability, it’s important that the DNA sequence controlling gene expression is brief. As well as, it should be particular for endothelial cells to keep away from off-target results.
To develop improved regulatory sequences with selectivity for mind endothelial cells, we examined the transcriptional exercise of truncated promoters of 11 (mind) endothelial-specific genes together with quick regulatory parts, i.e., the woodchuck post-transcriptional regulatory ingredient (W), the CMV enhancer ingredient (C), and a fraction of the primary intron of the Tie2 gene (S), by transfecting mind endothelial cells of three species.
4 mixtures of regulatory parts and quick promoters (Cdh5, Ocln, Slc2a1, and Slco1c1) progressed by means of this in-vitro pipeline displaying appropriate exercise. When examined in mice, the regulatory sequences C-Ocln-W and C-Slc2a1-S-W enabled a stronger and extra particular gene expression in mind endothelial cells than the steadily used CAG promoter. In abstract, the brand new regulatory parts effectively management gene expression in mind endothelial cells and should assist to particularly goal the blood-brain barrier with gene remedy vectors.
From Pancreatic β–Cell Gene Networks to Novel Therapies for Kind 1 Diabetes
Completion of the Human Genome Mission enabled a novel systems- and network-level understanding of biology, however this stays to be utilized for understanding the pathogenesis of sort 1 diabetes (T1D). We suggest that defining the important thing gene regulatory networks that drive β-cell dysfunction and loss of life in T1D would possibly allow the design of therapies that focus on the core illness mechanism, specifically, the progressive lack of pancreatic β-cells.
Certainly, many profitable medicine don’t immediately goal particular person illness genes however, moderately, modulate the implications of faulty steps, focusing on proteins positioned one or two steps downstream. If we transpose this to the T1D scenario, it is smart to focus on the pathways that modulate the β-cell responses to the immune assault-in relation to indicators which will stimulate the immune response (e.g., HLA class I and chemokine overexpression and/or neoantigen expression) or inhibit the invading immune cells (e.g., PDL1 and HLA-E expression)-instead of focusing on solely the immune system, as it’s normally proposed.
Right here we talk about the significance of a give attention to β-cells in T1D, classes realized from different autoimmune illnesses, the “different splicing connection,” information mining, and drug repurposing to guard β-cells in T1D after which among the preliminary candidates below testing for β-cell safety.
Danger evaluation of leachables in cell and gene remedy utilizing a CAR-T mannequin course of
With the quickly rising subject of autologous therapies, Single-Use (SU) applied sciences are more and more utilized in personalised medication resulting from their manifold benefits. Though qualification of the beginning materials of autologous therapies such because the CAR-T course of has been highlighted, little consideration has been paid to the impact of leachables on cell-based therapies, even when latest research point out interactions of leachables with cells.
To shut this hole, this examine presents a risk-analysis of SU-material on a CAR-T course of and identifies hazards imposed by tubing supplies and leachables thereof. With a purpose to symbolize a CAR-T course of in its entirety, two check programs, specifically a lentivirus manufacturing course of and first T-cells, had been used. Whereas the results on lentivirus manufacturing are similar to these reported for antibody manufacturing processes in CHO cells, we discovered that PVC materials and corresponding leachables, i.e. plasticizer, inhibit cell development of main T-cells to a fantastic extent. Moreover, our outcomes point out that important high quality attributes are affected by the PVC materials.
Engineering genetic units for in vivo management of therapeutic T cell exercise triggered by the dietary molecule resveratrol
Chimeric antigen receptor (CAR)-engineered T cell therapies have been acknowledged as highly effective methods in most cancers immunotherapy; nevertheless, the scientific software of CAR-T is at present constrained by extreme opposed results in sufferers, brought on by extreme cytotoxic exercise and poor T cell management. Herein, we harnessed a dietary molecule resveratrol (RES)-responsive transactivator and a transrepressor to develop a repressible transgene expression (RESrep) gadget and an inducible transgene expression (RESind) gadget, respectively.
After optimization, these instruments enabled the management of CAR expression and CAR-mediated antitumor operate in engineered human cells. We demonstrated {that a} resveratrol-repressible CAR expression (RESrep-CAR) gadget can successfully inhibit T cell activation upon resveratrol administration in main T cells and a xenograft tumor mouse mannequin.
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
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| abx415211-05mg | Abbexa | 0.5 mg | EUR 994.8 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
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| abx415213-01mg | Abbexa | 0.1 mg | EUR 526.8 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
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| abx415215-05mg | Abbexa | 0.5 mg | EUR 994.8 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
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| abx415216-01mg | Abbexa | 0.1 mg | EUR 526.8 |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
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| CM03-10ug | Novoprotein | 10ug | EUR 151.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
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| CM03-1mg | Novoprotein | 1mg | EUR 2252.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
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| CM03-500ug | Novoprotein | 500ug | EUR 1593.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
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| CM03-50ug | Novoprotein | 50ug | EUR 278.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CM54-10ug | Novoprotein | 10ug | EUR 151.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CM54-1mg | Novoprotein | 1mg | EUR 2252.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CM54-500ug | Novoprotein | 500ug | EUR 1593.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CM54-50ug | Novoprotein | 50ug | EUR 278.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CK57-10ug | Novoprotein | 10ug | EUR 132 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CK57-1mg | Novoprotein | 1mg | EUR 2008.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CK57-500ug | Novoprotein | 500ug | EUR 1423.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CK57-50ug | Novoprotein | 50ug | EUR 278.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (RPE) |
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| abx415207-100tests | Abbexa | 100 tests | EUR 710.4 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE) |
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| abx415214-100tests | Abbexa | 100 tests | EUR 710.4 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC) |
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| abx415205-01mg | Abbexa | 0.1 mg | EUR 610.8 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC) |
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| abx415212-01mg | Abbexa | 0.1 mg | EUR 610.8 |
Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
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| 32146-05111 | AssayPro | 150 ug | EUR 313.2 |
T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody |
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| abx415208-05mg | Abbexa | 0.5 mg | EUR 994.8 |
T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody |
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| abx415210-01mg | Abbexa | 0.1 mg | EUR 526.8 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKU11802-48T | Biomatik Corporation | 48T | EUR 571.55 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKU11802-5x96T | Biomatik Corporation | 5x96T | EUR 3878.38 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKU11802-96T | Biomatik Corporation | 96T | EUR 816.5 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKN52913-48T | Biomatik Corporation | 48T | EUR 355.6 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKN52913-5x96T | Biomatik Corporation | 5x96T | EUR 2413 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKN52913-96T | Biomatik Corporation | 96T | EUR 508 |
Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His) |
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| C356-10ug | Novoprotein | 10ug | EUR 145.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
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Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His) |
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| C356-1mg | Novoprotein | 1mg | EUR 2739.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
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Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His) |
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| C356-500ug | Novoprotein | 500ug | EUR 1935.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
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Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His) |
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| C356-50ug | Novoprotein | 50ug | EUR 315.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2. |
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T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody (FITC) |
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| abx415209-01mg | Abbexa | 0.1 mg | EUR 610.8 |
Human T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) ELISA Kit |
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| SL3234Hu | Sunlong | 96 Tests | EUR 468 |
Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (Biotin Conjugate) |
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| 32146-05121 | AssayPro | 150 ug | EUR 442.8 |
T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody |
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| 20-abx174727 | Abbexa |
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T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody |
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| 20-abx178542 | Abbexa |
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T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody |
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| 20-abx318087 | Abbexa |
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T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody |
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| abx031021-400ul | Abbexa | 400 ul | EUR 627.6 |
T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody |
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| abx031021-80l | Abbexa | 80 µl | EUR 343.2 |
Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His) |
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| CX71-10ug | Novoprotein | 10ug | EUR 145.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His) |
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| CX71-1mg | Novoprotein | 1mg | EUR 2739.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His) |
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| CX71-500ug | Novoprotein | 500ug | EUR 1935.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His) |
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| CX71-50ug | Novoprotein | 50ug | EUR 315.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (FITC Conjugate) |
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| 32146-05141 | AssayPro | 150 ug | EUR 513.6 |
Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (RPE Conjugate) |
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| 32146-05151 | AssayPro | 150 ug | EUR 513.6 |
Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (APC Conjugate) |
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| 32146-05161 | AssayPro | 150 ug | EUR 513.6 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 ELISA Kit |
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| IHUTIMD4KT | Innovative research | each | EUR 733 |
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Description: Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 ELISA Kit |
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T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (HRP) |
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| 20-abx316455 | Abbexa |
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T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (FITC) |
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| 20-abx316456 | Abbexa |
|
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Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (PerCP Conjugate) |
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| 32146-05171 | AssayPro | 150 ug | EUR 565.2 |
Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) |
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| 4-RPH854Hu01 | Cloud-Clone |
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Description: Recombinant Human Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) expressed in: E.coli |
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Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) |
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| RPU56012-100ug | Biomatik Corporation | 100ug | EUR 554.4 |
Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) |
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| RPU56012-1mg | Biomatik Corporation | 1mg | EUR 2184 |
Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) |
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| RPU56012-50ug | Biomatik Corporation | 50ug | EUR 336 |
T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (Biotin) |
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| 20-abx316457 | Abbexa |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein |
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| 20-abx655199 | Abbexa |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) CLIA Kit |
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| 20-abx495562 | Abbexa |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| DLR-TIMD4-Hu-48T | DL Develop | 48T | EUR 620.4 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| DLR-TIMD4-Hu-96T | DL Develop | 96T | EUR 807.6 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates or other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| 20-abx153299 | Abbexa |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 ELISA Kit (TIMD4) |
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| RK02389 | Abclonal | 96 Tests | EUR 625.2 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| RDR-TIMD4-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 652.8 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| RDR-TIMD4-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 907.2 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| RD-TIMD4-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 625.2 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| RD-TIMD4-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 867.6 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| DLR-TIMD4-Hu | DL Develop | 96T | EUR 463 |
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Description: tissue homogenates, cell lysates or other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| DL-TIMD4-Hu | DL Develop | 96T | EUR 441 |
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Description: tissue homogenates, cell lysates or other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| RDR-TIMD4-Hu-48T | Reddot Biotech | 48T | EUR 475.34 |
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Description: tissue homogenates, cell lysates and other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| RDR-TIMD4-Hu-96T | Reddot Biotech | 96T | EUR 679.04 |
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Description: tissue homogenates, cell lysates and other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| RD-TIMD4-Hu-48T | Reddot Biotech | 48T | EUR 452.7 |
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Description: tissue homogenates, cell lysates and other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| RD-TIMD4-Hu-96T | Reddot Biotech | 96T | EUR 646.7 |
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Description: tissue homogenates, cell lysates and other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| SEH854Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5677.8 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| SEH854Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 572.76 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| SEH854Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 766.8 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| SEH854Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 3090.6 |
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Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| 4-SEH854Hu | Cloud-Clone |
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. |
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Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKU07581-48T | Biomatik Corporation | 48T | EUR 555.66 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKU07581-5x96T | Biomatik Corporation | 5x96T | EUR 3770.55 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKU07581-96T | Biomatik Corporation | 96T | EUR 793.8 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKN48692-48T | Biomatik Corporation | 48T | EUR 378.7 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKN48692-5x96T | Biomatik Corporation | 5x96T | EUR 2569.75 |
Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit |
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| EKN48692-96T | Biomatik Corporation | 96T | EUR 541 |
Human TIMD4(T-Cell Immunoglobulin And Mucin Domain Containing Protein 4) ELISA Kit |
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| ELK4680-48T | ELK Biotech | 48T | Ask for price |
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Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TIMD4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TIMD4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human TIMD4, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human TIMD4 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Human TIMD4(T-Cell Immunoglobulin And Mucin Domain Containing Protein 4) ELISA Kit |
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| ELK4680-96T | ELK Biotech | 96T | Ask for price |
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Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TIMD4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TIMD4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human TIMD4, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human TIMD4 in the samples is then determined by comparing the OD of the samples to the standard curve. |
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Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ELISA Kit |
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| abx352339-96tests | Abbexa | 96 tests | EUR 943.2 |
Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit |
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| CSB-EL023546HU-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
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Description: Quantitativesandwich ELISA kit for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
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Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit |
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| 1-CSB-EL023546HU | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
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Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit |
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| EKC41977-48T | Biomatik Corporation | 48T | EUR 535.99 |
Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit |
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| EKC41977-5x96T | Biomatik Corporation | 5x96T | EUR 3637.08 |
Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit |
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| EKC41977-96T | Biomatik Corporation | 96T | EUR 765.7 |
ELISA kit for Human TIMD4 (T-Cell Immunoglobulin And Mucin Domain Containing Protein 4) |
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| ELK4680 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
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Description: A sandwich ELISA kit for detection of T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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ELISA kit for Human TIMD4 (T-cell immunoglobulin and mucin domain-containing protein 4) |
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| E-EL-H5515 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
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Description: A sandwich ELISA kit for quantitative measurement of Human TIMD4 (T-cell immunoglobulin and mucin domain-containing protein 4) in samples from Serum, Plasma, Cell supernatant |
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ELISA kit for Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) |
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| KTE62326-48T | Abbkine | 48T | EUR 398.4 |
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Description: Quantitative sandwich ELISA for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) |
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| KTE62326-5platesof96wells | Abbkine | 5 plates of 96 wells | EUR 2538 |
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Description: Quantitative sandwich ELISA for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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ELISA kit for Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) |
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| KTE62326-96T | Abbkine | 96T | EUR 646.8 |
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Description: Quantitative sandwich ELISA for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
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Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial |
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| RPC28317-100ug | Biomatik Corporation | 100ug | EUR 1931.2 |
Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial |
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| RPC28317-1mg | Biomatik Corporation | 1mg | EUR 8577 |
Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial |
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| RPC28317-20ug | Biomatik Corporation | 20ug | EUR 726 |
Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial |
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| RPC28361-100ug | Biomatik Corporation | 100ug | EUR 1931.2 |
Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial |
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| RPC28361-1mg | Biomatik Corporation | 1mg | EUR 8577 |
Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial |
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| RPC28361-20ug | Biomatik Corporation | 20ug | EUR 726 |
T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Magnetic Luminex Assay Kit |
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| LKU603602-96T | Biomatik Corporation | 96T | EUR 966 |
T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Magnetic Luminex Assay Kit |
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| LKU603605-96T | Biomatik Corporation | 96T | EUR 993.6 |
Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His) |
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| CU18-10ug | Novoprotein | 10ug | EUR 169.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His) |
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| CU18-1mg | Novoprotein | 1mg | EUR 2008.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His) |
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| CU18-500ug | Novoprotein | 500ug | EUR 1423.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His) |
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| CU18-50ug | Novoprotein | 50ug | EUR 363.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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TIM3 (T-Cell Immunoglobulin)/HAVCR2 |
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| MO47039 | Neuromics | 100 ul | EUR 418.8 |
Mouse Immunoglobulin G-2(IgG-2)ELISA Kit |
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| YLA0458MO-48T | Shanghai YL Biotech | 48T | EUR 465 |
Mouse Immunoglobulin G-2(IgG-2)ELISA Kit |
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| YLA0458MO-96T | Shanghai YL Biotech | 96T | EUR 600 |
Mouse Immunoglobulin G (IgG) Antibody |
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| 40012-05011 | AssayPro | 150 ug | EUR 260.4 |
Mouse Anti Rat Immunoglobulin A Monoclonal Antibody |
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| DMABT-49896MR | Creative Diagnostics | 0.5 mg | EUR 1070.4 |
Mouse Anti-lymphocyte Immunoglobulin(ALG) ELISA Kit |
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| NSL1022m | Sunlong | 96 Test | EUR 528 |
Mouse Immunoglobulin G (IgG) (Fc) Antibody |
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| 40011-05011 | AssayPro | 150 ug | EUR 260.4 |
immunoglobulin Kappa (immunoglobulin kappa) Antibody |
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| abx234295-100ug | Abbexa | 100 ug | EUR 610.8 |
Mouse Immunoglobulin J chain (Igj) |
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| 1-CSB-YP011337MO | Cusabio |
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Description: Recombinant Mouse Immunoglobulin J chain(Igj) expressed in Yeast |
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Mouse Immunoglobulin A1 ELISA kit |
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| E03I0016-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Immunoglobulin A1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Immunoglobulin A1 ELISA kit |
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| E03I0016-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Mouse Immunoglobulin A1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Immunoglobulin A1 ELISA kit |
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| E03I0016-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Mouse Immunoglobulin A1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Mouse Immunoglobulin A ELISA kit |
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| E03I0021-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Mouse Immunoglobulin A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Moreover, we exhibit how a resveratrol-inducible CAR expression (RESind-CAR) gadget can obtain fine-tuned and reversible management over T cell activation through a resveratrol-titratable mechanism. Moreover, our outcomes revealed that the presence of RES can activate RESind-CAR T cells with robust anticancer cytotoxicity towards cells in vitro and in vivo. Our examine demonstrates the utility of RESrep and RESind units as efficient instruments for transgene expression and illustrates the potential of RESrep-CAR and RESind-CAR units to boost affected person security in precision most cancers immunotherapies.