Gene vectors focusing on CNS endothelial cells enable to govern the blood-brain barrier and to right genetic defects within the CNS. As a result of vectors based mostly on the adeno-associated virus (AAV) have a restricted capability, it’s important that the DNA sequence controlling gene expression is brief. As well as, it should be particular for endothelial cells to keep away from off-target results.
To develop improved regulatory sequences with selectivity for mind endothelial cells, we examined the transcriptional exercise of truncated promoters of 11 (mind) endothelial-specific genes together with quick regulatory parts, i.e., the woodchuck post-transcriptional regulatory ingredient (W), the CMV enhancer ingredient (C), and a fraction of the primary intron of the Tie2 gene (S), by transfecting mind endothelial cells of three species.
4 mixtures of regulatory parts and quick promoters (Cdh5, Ocln, Slc2a1, and Slco1c1) progressed by means of this in-vitro pipeline displaying appropriate exercise. When examined in mice, the regulatory sequences C-Ocln-W and C-Slc2a1-S-W enabled a stronger and extra particular gene expression in mind endothelial cells than the steadily used CAG promoter. In abstract, the brand new regulatory parts effectively management gene expression in mind endothelial cells and should assist to particularly goal the blood-brain barrier with gene remedy vectors.
From Pancreatic β–Cell Gene Networks to Novel Therapies for Kind 1 Diabetes
Completion of the Human Genome Mission enabled a novel systems- and network-level understanding of biology, however this stays to be utilized for understanding the pathogenesis of sort 1 diabetes (T1D). We suggest that defining the important thing gene regulatory networks that drive β-cell dysfunction and loss of life in T1D would possibly allow the design of therapies that focus on the core illness mechanism, specifically, the progressive lack of pancreatic β-cells.
Certainly, many profitable medicine don’t immediately goal particular person illness genes however, moderately, modulate the implications of faulty steps, focusing on proteins positioned one or two steps downstream. If we transpose this to the T1D scenario, it is smart to focus on the pathways that modulate the β-cell responses to the immune assault-in relation to indicators which will stimulate the immune response (e.g., HLA class I and chemokine overexpression and/or neoantigen expression) or inhibit the invading immune cells (e.g., PDL1 and HLA-E expression)-instead of focusing on solely the immune system, as it’s normally proposed.
Right here we talk about the significance of a give attention to β-cells in T1D, classes realized from different autoimmune illnesses, the “different splicing connection,” information mining, and drug repurposing to guard β-cells in T1D after which among the preliminary candidates below testing for β-cell safety.
Danger evaluation of leachables in cell and gene remedy utilizing a CAR-T mannequin course of
With the quickly rising subject of autologous therapies, Single-Use (SU) applied sciences are more and more utilized in personalised medication resulting from their manifold benefits. Though qualification of the beginning materials of autologous therapies such because the CAR-T course of has been highlighted, little consideration has been paid to the impact of leachables on cell-based therapies, even when latest research point out interactions of leachables with cells.
To shut this hole, this examine presents a risk-analysis of SU-material on a CAR-T course of and identifies hazards imposed by tubing supplies and leachables thereof. With a purpose to symbolize a CAR-T course of in its entirety, two check programs, specifically a lentivirus manufacturing course of and first T-cells, had been used. Whereas the results on lentivirus manufacturing are similar to these reported for antibody manufacturing processes in CHO cells, we discovered that PVC materials and corresponding leachables, i.e. plasticizer, inhibit cell development of main T-cells to a fantastic extent. Moreover, our outcomes point out that important high quality attributes are affected by the PVC materials.
Engineering genetic units for in vivo management of therapeutic T cell exercise triggered by the dietary molecule resveratrol
Chimeric antigen receptor (CAR)-engineered T cell therapies have been acknowledged as highly effective methods in most cancers immunotherapy; nevertheless, the scientific software of CAR-T is at present constrained by extreme opposed results in sufferers, brought on by extreme cytotoxic exercise and poor T cell management. Herein, we harnessed a dietary molecule resveratrol (RES)-responsive transactivator and a transrepressor to develop a repressible transgene expression (RESrep) gadget and an inducible transgene expression (RESind) gadget, respectively.
After optimization, these instruments enabled the management of CAR expression and CAR-mediated antitumor operate in engineered human cells. We demonstrated {that a} resveratrol-repressible CAR expression (RESrep-CAR) gadget can successfully inhibit T cell activation upon resveratrol administration in main T cells and a xenograft tumor mouse mannequin.
Anti-Mouse T-cell Immunoglobulin Mucin-1 (TIM-1) Antibody |
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| 103-M274 | ReliaTech | 100 µg | EUR 399 |
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Description: MUC-1 (Mucin-1; also PEM, PEMT, Episialin, tumor-associated mucin, and carcinoma associated mucin) is a 240-450 kDa type I transmembrane glycoprotein. Human MUC-1 is 1255 amino acids (aa) in length and contains a 23 aa signal sequence, a 1135 aa extracellular domain (ECD), a 23 aa transmembrane segment, and a 74 aa cytoplasmic tail. The ECD consists of degenerate tandem repeats and a tandem repeat region, which makes up the major portion of the protein. Potential O-glycosylation sites (serines and threonines) make up more than one-fourth of the amino acids. Splicing variants produce ten isoforms for human MUC-1. Human MUC-1 is 28% aa identical to mouse MUC-1. |
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Anti-Mouse T-cell Immunoglobulin Mucin-3 (TIM-3) Antibody |
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| 103-M276 | ReliaTech | 100 µg | EUR 399 |
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Description: T cell immunoglobulin mucin-3 (TIM-3) is a member of the T-cell Immunoglobulin- and Mucin-domain-containing family of type I membrane glycoproteins that regulate autoimmune and allergic disease. TIM-3 is selectively expressed on Th1 cells and interacts with galectin-9. It negatively regulates Th1 responses and affects macrophage activation. The 280 aa mature human TIM-3 contains a V-type Ig-like domain that shows multiple polymorphisms, followed by a mucin-like domain in the 171 aa extracellular region, which shares 60% amino acid identity with mouse TIM-3 ECD. One splice variant of TIM-3 is truncated within the mucin domain and presumably is secreted. |
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TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE) |
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| MBS6252227-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (PE) |
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| MBS6252227-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP) |
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| MBS6248356-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (AP) |
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| MBS6248356-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP) |
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| MBS6251291-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (HRP) |
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| MBS6251291-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC) |
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| MBS6269208-01mL | MyBiosource | 0.1mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (APC) |
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| MBS6269208-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC) |
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| MBS6250264-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (FITC) |
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| MBS6250264-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
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| CM03-10ug | Novoprotein | 10ug | EUR 151.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
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| CM03-1mg | Novoprotein | 1mg | EUR 2252.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
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| CM03-500ug | Novoprotein | 500ug | EUR 1593.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
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| CM03-50ug | Novoprotein | 50ug | EUR 278.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc) |
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| AP76216 | SAB | 1mg | EUR 2649 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin) |
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| MBS6249364-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (Biotin) |
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| MBS6249364-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CK57-10ug | Novoprotein | 10ug | EUR 132 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CK57-1mg | Novoprotein | 1mg | EUR 2008.8 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CK57-500ug | Novoprotein | 500ug | EUR 1423.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CK57-50ug | Novoprotein | 50ug | EUR 278.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CM54-10ug | Novoprotein | 10ug | EUR 151.2 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CM54-1mg | Novoprotein | 1mg | EUR 2252.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CM54-500ug | Novoprotein | 500ug | EUR 1593.6 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| CM54-50ug | Novoprotein | 50ug | EUR 278.4 |
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Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
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Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| AP76176 | SAB | 1mg | EUR 2369 |
Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His) |
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| AP76258 | SAB | 1mg | EUR 2649 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody |
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| abx430303-200ul | Abbexa | 200 ul | EUR 460.8 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM3) Antibody |
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| 20-abx225210 | Abbexa |
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TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 405) |
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| MBS6253266-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 405) |
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| MBS6253266-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 490) |
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| MBS6254306-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 490) |
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| MBS6254306-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 550) |
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| MBS6255346-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 550) |
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| MBS6255346-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 650) |
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| MBS6256386-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 650) |
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| MBS6256386-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 750) |
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| MBS6257425-01mL | MyBiosource | 0.1mL | EUR 860 |
TIM-2 (T-cell Immunoglobulin Mucin 2, Timd2, Tim2) (MaxLight 750) |
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| MBS6257425-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
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| abx433377-100g | Abbexa | 100 µg | EUR 387.5 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
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| abx433377-200ul | Abbexa | 200 ul | EUR 460.8 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
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| abx411874-01mg | Abbexa | 0.1 mg | EUR 644.4 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
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| abx411874-100g | Abbexa | 100 µg | EUR 437.5 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
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| abx411875-01mg | Abbexa | 0.1 mg | EUR 661.2 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
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| abx411875-100tests | Abbexa | 100 tests | EUR 450 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
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| abx412054-01mg | Abbexa | 0.1 mg | EUR 844.8 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
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| abx415204-05mg | Abbexa | 0.5 mg | EUR 994.8 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
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| abx415206-01mg | Abbexa | 0.1 mg | EUR 526.8 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
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| abx415206-200l | Abbexa | 200 µl | EUR 337.5 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
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| abx415211-05mg | Abbexa | 0.5 mg | EUR 994.8 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
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| abx415213-01mg | Abbexa | 0.1 mg | EUR 526.8 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
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| abx415215-05mg | Abbexa | 0.5 mg | EUR 994.8 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
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| abx415216-01mg | Abbexa | 0.1 mg | EUR 526.8 |
T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody |
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| abx415216-200l | Abbexa | 200 µl | EUR 337.5 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody |
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| abx375362-96tests | Abbexa | 96 tests | EUR 337.5 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
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| MBS3807468-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
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| MBS3807468-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
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| MBS3807468-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse Solubility T Cell Immunoglobulin-and Mucin-Domain-Containing Molecule-3 ELISA Kit |
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| MBS3807468-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (PE) |
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| abx415207-200l | Abbexa | 200 µl | EUR 487.5 |
Timd2 (GFP-tagged) - Mouse T-cell immunoglobulin and mucin domain containing 2 (Timd2) |
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| MG204271 | Origene Technologies GmbH | 10 µg | Ask for price |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE) |
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| MBS6252229-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (PE) |
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| MBS6252229-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP) |
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| MBS6248358-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (AP) |
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| MBS6248358-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (RPE) |
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| abx415207-100tests | Abbexa | 100 tests | EUR 710.4 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE) |
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| abx415214-100tests | Abbexa | 100 tests | EUR 710.4 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP) |
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| MBS6251293-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (HRP) |
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| MBS6251293-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC) |
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| MBS6269210-01mL | MyBiosource | 0.1mL | EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (APC) |
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| MBS6269210-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC) |
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| abx415205-01mg | Abbexa | 0.1 mg | EUR 610.8 |
T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC) |
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| abx415205-200l | Abbexa | 200 µl | EUR 400 |
T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC) |
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| abx415212-01mg | Abbexa | 0.1 mg | EUR 610.8 |
Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (TIMD2) ELISA Kit |
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| abx549772-96tests | Abbexa | 96 tests | EUR 687.5 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC) |
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| MBS6250266-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (FITC) |
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| MBS6250266-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
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| MBS069521-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
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| MBS069521-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
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| MBS069521-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Mouse T-Cell Immunoglobulin and Mucin Domain Containing Protein 4 ELISA Kit |
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| MBS069521-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody |
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| 32146-05111 | AssayPro | 150 ug | EUR 215 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin) |
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| MBS6249366-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-4 (T-cell Immunoglobulin Mucin 4, Tim4, Timd4) (Biotin) |
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| MBS6249366-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
Mouse T-cell immunoglobulin and mucin domain-containing protein 4 ELISA kit |
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| E03T0955-48wellsplate | BlueGene | 48 wells plate | EUR 280 |
Mouse T-cell immunoglobulin and mucin domain-containing protein 4 ELISA kit |
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| E03T0955-96wellsplate | BlueGene | 96 wells plate | EUR 405 |
T-cell immunoglobulin and mucin domain 1( TIM-1)antibody |
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| NBP0210-1 | Bioworld Biotech | each | Ask for price |
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Description: LF EIA,CLIA |
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T-cell immunoglobulin and mucin domain 1( TIM-1)antibody |
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| NBP0210-2 | Bioworld Biotech | each | Ask for price |
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Description: LF EIA,CLIA |
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Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein |
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| abx692171-100g | Abbexa | 100 µg | EUR 837.5 |
Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein |
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| abx692171-1mg | Abbexa | 1 mg | Ask for price |
Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
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| MBS620755-01mg | MyBiosource | 0.1mg | EUR 810 |
Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
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| MBS620755-5x01mg | MyBiosource | 5x0.1mg | EUR 3500 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
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| MBS6506798-01mL | MyBiosource | 0.1mL | EUR 715 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) |
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| MBS6506798-5x01mL | MyBiosource | 5x0.1mL | EUR 3075 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE) |
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| MBS6252228-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (PE) |
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| MBS6252228-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP) |
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| MBS6248357-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (AP) |
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| MBS6248357-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
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| MBS1369680-005mgBaculovirus | MyBiosource | 0.05mg(Baculovirus) | EUR 1110 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
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| MBS1369680-005mgMammalianCell | MyBiosource | 0.05mg(Mammalian-Cell) | EUR 1330 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
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| MBS1369680-05mgEColi | MyBiosource | 0.5mg(E-Coli) | EUR 1110 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
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| MBS1369680-05mgYeast | MyBiosource | 0.5mg(Yeast) | EUR 1330 |
Recombinant Mouse T-cell immunoglobulin and mucin domain-containing protein 2 (Timd2), partial |
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| MBS1369680-1mgEColi | MyBiosource | 1mg(E-Coli) | EUR 1625 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP) |
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| MBS6251292-01mL | MyBiosource | 0.1(mL | EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (HRP) |
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| MBS6251292-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC) |
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| MBS6269209-01mL | MyBiosource | 0.1mL | EUR 860 |
TIM-3 (Tim3, Timd3, T-cell Immunoglobulin Mucin 3, Havcr2) (APC) |
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| MBS6269209-5x01mL | MyBiosource | 5x0.1mL | EUR 3720 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (HRP) |
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| MBS6244130-01mL | MyBiosource | 0.1(mL | EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (HRP) |
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| MBS6244130-5x01mL | MyBiosource | 5x0.1mL | EUR 4375 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (PE) |
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| MBS6244663-01mL | MyBiosource | 0.1(mL | EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (PE) |
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| MBS6244663-5x01mL | MyBiosource | 5x0.1mL | EUR 4375 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC) |
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| MBS6242532-01mL | MyBiosource | 0.1(mL | EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC) |
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| MBS6242532-5x01mL | MyBiosource | 5x0.1mL | EUR 4375 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (Biotin) |
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| MBS6243064-01mL | MyBiosource | 0.1(mL | EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (Biotin) |
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| MBS6243064-5x01mL | MyBiosource | 5x0.1mL | EUR 4375 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC) |
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| MBS6243597-01mL | MyBiosource | 0.1(mL | EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (FITC) |
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| MBS6243597-5x01mL | MyBiosource | 5x0.1mL | EUR 4375 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP) |
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| MBS6241999-01mL | MyBiosource | 0.1(mL | EUR 1005 |
TIM3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (AP) |
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| MBS6241999-5x01mL | MyBiosource | 5x0.1mL | EUR 4375 |
Tim3 (T Cell Immunoglobulin and Mucin Domain-containing 3, T Cell Immunoglobulin Mucin 3, TIM3, TIM-3, TIMD3, FLJ14428, Hepatitis A Virus Cellular Receptor 2, HAVCR 2, HAVCR2, HAVCR-2, Kidney Injury Molecule 3, KIM-3) (APC) |
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| MBS606914-100Tests | MyBiosource | 100Tests | EUR 935 |
Moreover, we exhibit how a resveratrol-inducible CAR expression (RESind-CAR) gadget can obtain fine-tuned and reversible management over T cell activation through a resveratrol-titratable mechanism. Moreover, our outcomes revealed that the presence of RES can activate RESind-CAR T cells with robust anticancer cytotoxicity towards cells in vitro and in vivo. Our examine demonstrates the utility of RESrep and RESind units as efficient instruments for transgene expression and illustrates the potential of RESrep-CAR and RESind-CAR units to boost affected person security in precision most cancers immunotherapies.