Short regulatory DNA sequences to target brain endothelial cells for gene therapy

Short regulatory DNA sequences to target brain endothelial cells for gene therapy

Gene vectors focusing on CNS endothelial cells enable to govern the blood-brain barrier and to right genetic defects within the CNS. As a result of vectors based mostly on the adeno-associated virus (AAV) have a restricted capability, it’s important that the DNA sequence controlling gene expression is brief. As well as, it should be particular for endothelial cells to keep away from off-target results.
To develop improved regulatory sequences with selectivity for mind endothelial cells, we examined the transcriptional exercise of truncated promoters of 11 (mind) endothelial-specific genes together with quick regulatory parts, i.e., the woodchuck post-transcriptional regulatory ingredient (W), the CMV enhancer ingredient (C), and a fraction of the primary intron of the Tie2 gene (S), by transfecting mind endothelial cells of three species.
4 mixtures of regulatory parts and quick promoters (Cdh5OclnSlc2a1, and Slco1c1) progressed by means of this in-vitro pipeline displaying appropriate exercise. When examined in mice, the regulatory sequences C-Ocln-W and C-Slc2a1-S-W enabled a stronger and extra particular gene expression in mind endothelial cells than the steadily used CAG promoter. In abstract, the brand new regulatory parts effectively management gene expression in mind endothelial cells and should assist to particularly goal the blood-brain barrier with gene remedy vectors.

From Pancreatic βCell Gene Networks to Novel Therapies for Kind 1 Diabetes

Completion of the Human Genome Mission enabled a novel systems- and network-level understanding of biology, however this stays to be utilized for understanding the pathogenesis of sort 1 diabetes (T1D). We suggest that defining the important thing gene regulatory networks that drive β-cell dysfunction and loss of life in T1D would possibly allow the design of therapies that focus on the core illness mechanism, specifically, the progressive lack of pancreatic β-cells.
Certainly, many profitable medicine don’t immediately goal particular person illness genes however, moderately, modulate the implications of faulty steps, focusing on proteins positioned one or two steps downstream. If we transpose this to the T1D scenario, it is smart to focus on the pathways that modulate the β-cell responses to the immune assault-in relation to indicators which will stimulate the immune response (e.g., HLA class I and chemokine overexpression and/or neoantigen expression) or inhibit the invading immune cells (e.g., PDL1 and HLA-E expression)-instead of focusing on solely the immune system, as it’s normally proposed.
Short regulatory DNA sequences to target brain endothelial cells for gene therapy
Right here we talk about the significance of a give attention to β-cells in T1D, classes realized from different autoimmune illnesses, the “different splicing connection,” information mining, and drug repurposing to guard β-cells in T1D after which among the preliminary candidates below testing for β-cell safety.

Danger evaluation of leachables in cell and gene remedy utilizing a CAR-T mannequin course of

With the quickly rising subject of autologous therapies, Single-Use (SU) applied sciences are more and more utilized in personalised medication resulting from their manifold benefits. Though qualification of the beginning materials of autologous therapies such because the CAR-T course of has been highlighted, little consideration has been paid to the impact of leachables on cell-based therapies, even when latest research point out interactions of leachables with cells.
To shut this hole, this examine presents a risk-analysis of SU-material on a CAR-T course of and identifies hazards imposed by tubing supplies and leachables thereof. With a purpose to symbolize a CAR-T course of in its entirety, two check programs, specifically a lentivirus manufacturing course of and first T-cells, had been used. Whereas the results on lentivirus manufacturing are similar to these reported for antibody manufacturing processes in CHO cells, we discovered that PVC materials and corresponding leachables, i.e. plasticizer, inhibit cell development of main T-cells to a fantastic extent. Moreover, our outcomes point out that important high quality attributes are affected by the PVC materials.

Engineering genetic units for in vivo management of therapeutic T cell exercise triggered by the dietary molecule resveratrol

Chimeric antigen receptor (CAR)-engineered T cell therapies have been acknowledged as highly effective methods in most cancers immunotherapy; nevertheless, the scientific software of CAR-T is at present constrained by extreme opposed results in sufferers, brought on by extreme cytotoxic exercise and poor T cell management. Herein, we harnessed a dietary molecule resveratrol (RES)-responsive transactivator and a transrepressor to develop a repressible transgene expression (RESrep) gadget and an inducible transgene expression (RESind) gadget, respectively.
After optimization, these instruments enabled the management of CAR expression and CAR-mediated antitumor operate in engineered human cells. We demonstrated {that a} resveratrol-repressible CAR expression (RESrep-CAR) gadget can successfully inhibit T cell activation upon resveratrol administration in main T cells and a xenograft tumor mouse mannequin.

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx415211-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

abx415213-01mg 0.1 mg
EUR 526.8

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415215-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin Mucin Receptor 4 (TIM-4) Antibody

abx415216-01mg 0.1 mg
EUR 526.8

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc)

CM03-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-10ug 10ug
EUR 151.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-1mg 1mg
EUR 2252.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-500ug 500ug
EUR 1593.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CM54-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-10ug 10ug
EUR 132
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Mouse T cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-6His)

CK57-50ug 50ug
EUR 278.4
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (RPE)

abx415207-100tests 100 tests
EUR 710.4

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (RPE)

abx415214-100tests 100 tests
EUR 710.4

T-Cell Immunoglobulin Mucin Receptor 1 (TIM-1) Antibody (FITC)

abx415205-01mg 0.1 mg
EUR 610.8

T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (FITC)

abx415212-01mg 0.1 mg
EUR 610.8

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody

32146-05111 150 ug
EUR 313.2

T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody

abx415208-05mg 0.5 mg
EUR 994.8

T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody

abx415210-01mg 0.1 mg
EUR 526.8

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU11802-48T 48T
EUR 571.55

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU11802-5x96T 5x96T
EUR 3878.38

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU11802-96T 96T
EUR 816.5

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN52913-48T 48T
EUR 355.6

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN52913-5x96T 5x96T
EUR 2413

Mouse T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN52913-96T 96T
EUR 508

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM3/HAVCR2 (C-6His)

C356-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.

T-Cell Immunoglobulin And Mucin Domain-Containing Protein 2 (TIM-2) Antibody (FITC)

abx415209-01mg 0.1 mg
EUR 610.8

Human T cell immunoglobulin and mucin domain-containing protein 3 (TIM3) ELISA Kit

SL3234Hu 96 Tests
EUR 468

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) Antibody (Biotin Conjugate)

32146-05121 150 ug
EUR 442.8

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody

20-abx174727
  • EUR 1028.40
  • EUR 526.80
  • 1 mg
  • 200 ug

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Antibody

20-abx178542
  • EUR 1446.00
  • EUR 693.60
  • 1 mg
  • 200 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

20-abx318087
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx031021-400ul 400 ul
EUR 627.6

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody

abx031021-80l 80 µl
EUR 343.2

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human T Cell Immunoglobulin and Mucin Domain-3/TIM-3/HAVCR2 (C-Fc-6His)

CX71-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (FITC Conjugate)

32146-05141 150 ug
EUR 513.6

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (RPE Conjugate)

32146-05151 150 ug
EUR 513.6

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (APC Conjugate)

32146-05161 150 ug
EUR 513.6

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 ELISA Kit

IHUTIMD4KT each
EUR 733
Description: Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 ELISA Kit

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (HRP)

20-abx316455
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (FITC)

20-abx316456
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human T-Cell Immunoglobulin Mucin Receptor 3 (TIM-3) AssayLite Antibody (PerCP Conjugate)

32146-05171 150 ug
EUR 565.2

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

4-RPH854Hu01
  • EUR 496.32
  • EUR 256.80
  • EUR 1531.20
  • EUR 590.40
  • EUR 1060.80
  • EUR 408.00
  • EUR 3648.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) expressed in: E.coli

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

RPU56012-100ug 100ug
EUR 554.4

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

RPU56012-1mg 1mg
EUR 2184

Recombinant T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4)

RPU56012-50ug 50ug
EUR 336

T-Cell immunoglobulin and mucin domain-Containing protein 4 (TIMD4) Antibody (Biotin)

20-abx316457
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Protein

20-abx655199
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) CLIA Kit

20-abx495562
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

DLR-TIMD4-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates or other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

DLR-TIMD4-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates or other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

20-abx153299
  • EUR 8853.60
  • EUR 4719.60
  • EUR 1093.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 ELISA Kit (TIMD4)

RK02389 96 Tests
EUR 625.2

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RDR-TIMD4-Hu-48Tests 48 Tests
EUR 652.8

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RDR-TIMD4-Hu-96Tests 96 Tests
EUR 907.2

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RD-TIMD4-Hu-48Tests 48 Tests
EUR 625.2

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RD-TIMD4-Hu-96Tests 96 Tests
EUR 867.6

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

DLR-TIMD4-Hu 96T
EUR 463
Description: tissue homogenates, cell lysates or other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

DL-TIMD4-Hu 96T
EUR 441
Description: tissue homogenates, cell lysates or other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RDR-TIMD4-Hu-48T 48T
EUR 475.34
Description: tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RDR-TIMD4-Hu-96T 96T
EUR 679.04
Description: tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RD-TIMD4-Hu-48T 48T
EUR 452.7
Description: tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

RD-TIMD4-Hu-96T 96T
EUR 646.7
Description: tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

SEH854Hu-10x96wellstestplate 10x96-wells test plate
EUR 5677.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

SEH854Hu-1x48wellstestplate 1x48-wells test plate
EUR 572.76
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

SEH854Hu-1x96wellstestplate 1x96-wells test plate
EUR 766.8
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

SEH854Hu-5x96wellstestplate 5x96-wells test plate
EUR 3090.6
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in tissue homogenates, cell lysates and other biological fluids.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

4-SEH854Hu
  • EUR 5738.40
  • EUR 3031.20
  • EUR 768.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU07581-48T 48T
EUR 555.66

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU07581-5x96T 5x96T
EUR 3770.55

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKU07581-96T 96T
EUR 793.8

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN48692-48T 48T
EUR 378.7

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN48692-5x96T 5x96T
EUR 2569.75

Human T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) ELISA Kit

EKN48692-96T 96T
EUR 541

Human TIMD4(T-Cell Immunoglobulin And Mucin Domain Containing Protein 4) ELISA Kit

ELK4680-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TIMD4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TIMD4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human TIMD4, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human TIMD4 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human TIMD4(T-Cell Immunoglobulin And Mucin Domain Containing Protein 4) ELISA Kit

ELK4680-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human TIMD4. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human TIMD4. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human TIMD4, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human TIMD4 in the samples is then determined by comparing the OD of the samples to the standard curve.

Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ELISA Kit

abx352339-96tests 96 tests
EUR 943.2

Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit

CSB-EL023546HU-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit

1-CSB-EL023546HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit

EKC41977-48T 48T
EUR 535.99

Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit

EKC41977-5x96T 5x96T
EUR 3637.08

Human T-cell immunoglobulin and mucin domain-containing protein 4(TIMD4) ELISA kit

EKC41977-96T 96T
EUR 765.7

ELISA kit for Human TIMD4 (T-Cell Immunoglobulin And Mucin Domain Containing Protein 4)

ELK4680 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human TIMD4 (T-cell immunoglobulin and mucin domain-containing protein 4)

E-EL-H5515 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human TIMD4 (T-cell immunoglobulin and mucin domain-containing protein 4) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4)

KTE62326-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4)

KTE62326-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4)

KTE62326-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial

RPC28317-100ug 100ug
EUR 1931.2

Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial

RPC28317-1mg 1mg
EUR 8577

Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial

RPC28317-20ug 20ug
EUR 726

Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial

RPC28361-100ug 100ug
EUR 1931.2

Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial

RPC28361-1mg 1mg
EUR 8577

Recombinant Human T-cell immunoglobulin and mucin domain-containing protein 4 (TIMD4) ,partial

RPC28361-20ug 20ug
EUR 726

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Magnetic Luminex Assay Kit

LKU603602-96T 96T
EUR 966

T-Cell Immunoglobulin And Mucin Domain Containing Protein 4 (TIMD4) Magnetic Luminex Assay Kit

LKU603605-96T 96T
EUR 993.6

Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His)

CU18-10ug 10ug
EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His)

CU18-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His)

CU18-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human T-cell Immunoglobulin and Mucin Domain-containing Protein 4/Tim-4 (C-6His)

CU18-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

TIM3 (T-Cell Immunoglobulin)/HAVCR2

MO47039 100 ul
EUR 418.8

Mouse Immunoglobulin G-2(IgG-2)ELISA Kit

YLA0458MO-48T 48T
EUR 465

Mouse Immunoglobulin G-2(IgG-2)ELISA Kit

YLA0458MO-96T 96T
EUR 600

Mouse Immunoglobulin G (IgG) Antibody

40012-05011 150 ug
EUR 260.4

Mouse Anti Rat Immunoglobulin A Monoclonal Antibody

DMABT-49896MR 0.5 mg
EUR 1070.4

Mouse Anti-lymphocyte Immunoglobulin(ALG) ELISA Kit

NSL1022m 96 Test
EUR 528

Mouse Immunoglobulin G (IgG) (Fc) Antibody

40011-05011 150 ug
EUR 260.4

immunoglobulin Kappa (immunoglobulin kappa) Antibody

abx234295-100ug 100 ug
EUR 610.8

Mouse Immunoglobulin J chain (Igj)

1-CSB-YP011337MO
  • EUR 604.80
  • EUR 318.00
  • EUR 2198.40
  • EUR 915.60
  • EUR 1459.20
  • EUR 400.80
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Mouse Immunoglobulin J chain(Igj) expressed in Yeast

Mouse Immunoglobulin A1 ELISA kit

E03I0016-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Immunoglobulin A1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Immunoglobulin A1 ELISA kit

E03I0016-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Mouse Immunoglobulin A1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Immunoglobulin A1 ELISA kit

E03I0016-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Mouse Immunoglobulin A1 in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Immunoglobulin A ELISA kit

E03I0021-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Mouse Immunoglobulin A in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.
Moreover, we exhibit how a resveratrol-inducible CAR expression (RESind-CAR) gadget can obtain fine-tuned and reversible management over T cell activation through a resveratrol-titratable mechanism. Moreover, our outcomes revealed that the presence of RES can activate RESind-CAR T cells with robust anticancer cytotoxicity towards cells in vitro and in vivo. Our examine demonstrates the utility of RESrep and RESind units as efficient instruments for transgene expression and illustrates the potential of RESrep-CAR and RESind-CAR units to boost affected person security in precision most cancers immunotherapies.

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