Comprehensive Study Identifies a Sensitive, Low-Risk, Closed-System Model for Detection of Fungal Contaminants in Cell and Gene Therapy Products

Comprehensive Study Identifies a Sensitive, Low-Risk, Closed-System Model for Detection of Fungal Contaminants in Cell and Gene Therapy Products

The US Meals and Drug Administration (FDA) regulates manufacturing and testing of superior therapeutic medicinal merchandise (ATMPs) to make sure the security of every product for human use. Gold normal sterility testing (USP<71>) and different blood tradition methods have main limitations for the detection of fungal contaminants. On this research, we evaluated the efficiency of iLYM media (designed initially for the meals and beverage trade) to evaluate its potential to be used within the biopharmaceutical subject for ATMP sterility testing.
We performed a parallel analysis of 4 totally different take a look at methods (USP<71>, BacT/ALERT, BACTEC, and Sabouraud Dextrose Agar [SDA] tradition), three totally different bottle media formulations (iLYM, iFA+, and Myco/F Lytic), and two incubation temperatures (22.5°C and 32.5-35°C) utilizing a various set of fungi (n=51) remoted from NIH cleanroom environments and former product contaminants. Moreover, we evaluated the impact of agitation versus “delayed entry” static pre-incubation on take a look at sensitivity and time to detection (TTD). General, delayed entry of bottles onto the BacT/ALERT or BACTEC devices (with agitation) didn’t enhance take a look at efficiency.
USP<71> and SDA tradition continued to considerably outperform every automated tradition situation alone. Nonetheless, we present for the primary time, {that a} closed-system, dual-bottle mixture of iLYM 22.5°C and iFA+ 32.5°C can present excessive fungal sensitivity, statistically corresponding to USP<71>, when examined in opposition to a various vary of environmental fungi. Our research fills a much-needed hole in biopharmaceutical testing and provides a good testing algorithm that maximizes bacterial and fungal take a look at sensitivity while minimizing threat of product contamination related to laboratory dealing with.
Comprehensive Study Identifies a Sensitive, Low-Risk, Closed-System Model for Detection of Fungal Contaminants in Cell and Gene Therapy Products

Gene-Edited Interleukin CAR-T Cells Remedy within the Remedy of Malignancies: Current and Future

Lately, chimeric antigen receptor T cells (CAR-T cells) have been confronted with the issues of weak proliferation and poor persistence within the remedy of some malignancies. Researchers have been attempting to excellent the perform of CAR-T by genetically modifying its construction. Along with the participation of T cell receptor (TCR) and costimulatory alerts, immune cytokines additionally exert a decisive function within the activation and proliferation of T cells.
Due to this fact, genetic engineering methods had been used to generate cytokines to boost tumor killing perform of CAR-T cells. When CAR-T cells are in touch with goal tumor tissue, the proliferation means and persistence of T cells might be improved by structurally or inductively releasing immunoregulatory molecules to the tumor area.
There are numerous CAR-T cells research on gene-edited cytokines, and the most typical cytokines concerned are interleukins (IL-7, IL-12, IL-15, IL-18, IL-21, IL-23). Strategies for the development of gene-edited interleukin CAR-T cells embrace co-expression of single interleukin, two interleukin, interleukin mixed with different cytokines, interleukin receptors, interleukin subunits, and fusion inverted cytokine receptors (ICR).
Preclinical and medical trials have yielded constructive outcomes, and lots of extra are underneath manner. By studying numerous literatures, we summarized the purposeful traits of some members of the interleukin household associated to tumor immunotherapy, and described the analysis standing of gene-edited interleukin CAR-T cells within the remedy of malignant tumors. The target is to discover the optimized technique of gene edited interleukin-CAR-T cell perform.

Improved Supply Strategies for Gene Remedy and Cell Transplantation in Parkinson’s Illness

Quite a lot of cell transplantation and gene remedy trials have been carried out during the last three many years in an effort to revive perform in Parkinson’s illness. A lot has been realized about optimizing supply strategies for these therapeutics. That is significantly true in gene remedy, which has predominated the medical trial panorama in recent times; nonetheless, cell transplantation for Parkinson’s illness is at present present process a renaissance.
Improvements reminiscent of cannula design, iMRI-guided surgical procedure and an evolution in supply technique has radically modified the way in which investigators method medical trial design. Future therapeutic methods could make use of newer supply strategies reminiscent of chronically implanted infusion gadgets and focal opening of the blood mind barrier with centered ultrasound.

SLC4A11 and MFSD3 Gene Expression Adjustments in Deoxynivalenol Handled IPEC-J2 Cells

Deoxynivalenol (DON) brought about critical cytotoxicity for animal cells. Nonetheless, genes concerned in regulating DON toxicity and the underlying molecular mechanisms stay largely unknown. This research explored the function of SLC4A11 and MFSD3 in assuaging DON toxicity and analyzed the DNA methylation adjustments of those two genes.
Viability and cell cycle evaluation confirmed that DON publicity decreased the IPEC-J2 viability (P < 0.01), blocked the cell cycle within the G2/M part (P < 0.01), and elevated the speed of apoptosis (P < 0.05). Expression of the SLC4A11 and MFSD3 genes was considerably downregulated upon DON publicity (P < 0.01).
Overexpression of SLC4A11 and MFSD3 can improve the cell viability (P < 0.01). DNA methylation assays indicated that promoter methylation of SLC4A11 (mC-1 and mC-23) and MFSD3 (mC-1 and mC-12) had been considerably increased in contrast with these within the controls and correlated negatively with mRNA expression (P < 0.05).

Stem Cell MicroRNA Profiling Panel

RA620A-1 10 profiles
EUR 1406.4

Mouse Stem Cell Factor (SCF) AssayMax ELISA Kit

EMS1001-1 96 Well Plate
EUR 475.2

Mouse Nanog Stem Cell Differentiation Reporter (pGreenZeo, plasmid)

SR10031PA-1 10 ug
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SARS-CoV-2 Spike S1 RBD Protein, Mouse Fc-fusion

E80026
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Mouse Nanog Stem Cell Differentiation Reporter (pGreenZeo, pre-packaged)

SR10031VA-1 >2 x 10^6 IFUs
EUR 906

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Histone H3 Methylation Antibody Panel Pack I – Active Genes

C10000
  • EUR 928.26
  • EUR 588.50
  • 4 x 25 µg
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Histone H3 Methylation Antibody Panel Pack I – Repression Genes

C10001
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Histone H3 Methylation Antibody Panel Pack II – Active Genes

C10002
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  • EUR 470.80
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Histone H3 Methylation Antibody Panel Pack II – Repression Genes

C10003
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Histone H3 Methylation Antibody Panel Pack III – Active Genes

C10004
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  • EUR 588.50
  • 4 x 25 µg
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Histone H3K4 Methylation Antibody Panel Pack

C10005
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  • EUR 470.80
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Histone H3K9 Methylation Antibody Panel Pack

C10006
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Histone H3K27 Methylation Antibody Panel Pack

C10007
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  • EUR 470.80
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Histone H3K36 Methylation Antibody Panel Pack

C10008
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  • EUR 470.80
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Histone H3K79 Methylation Antibody Panel Pack

C10009
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Histone H3 Acetylation Antibody Panel Pack I

C10010
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Histone H3 Acetylation Antibody Panel Pack II

C10011
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Histone H4K20 Methylation Antibody Panel Pack

C10012
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  • EUR 470.80
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Histone H4 Acetylation Antibody Panel Pack

C10013
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Histone H3 Phosphorylation Antibody Panel Pack

C10014
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Histone H3R2 Methylation Antibody Panel Pack

C10015
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  • EUR 470.80
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Histone H3R8 Methylation Antibody Panel Pack

C10016
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  • EUR 470.80
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Histone H3R17 Methylation Antibody Panel Pack

C10017
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
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Histone H3R26 Methylation Antibody Panel Pack

C10018
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
  • 3 x 25 ul

Histone H4R3 Methylation Antibody Panel Pack

C10019
  • EUR 754.26
  • EUR 470.80
  • 3 x 25 µg
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DNA Methylation Antibody Panel Pack I

C20000
  • EUR 458.46
  • EUR 270.60
  • 2 x 25 ul

DNMT3A Protein

E11000
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TET1 Protein (Active)

E12002
  • EUR 387.12
  • EUR 225.50
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DNMT3B Protein 

E14000
  • EUR 971.76
  • EUR 618.20
  • 10 µg
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DNMT1 Protein 

E15000
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  • EUR 618.20
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HDAC1 Protein 

E24002
  • EUR 968.28
  • EUR 616.00
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HDAC10 Protein 

E24003
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HDAC11 Protein 

E24004
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HDAC2 Protein 

E24005
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HDAC3 Protein 

E24006
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HDAC4 Protein 

E24007
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  • EUR 616.00
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HDAC5 Protein 

E24008
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HDAC6 Protein 

E24009
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HDAC7 Protein 

E24010
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HDAC8 Protein 

E24011
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HDAC9 Protein 

E24012
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  • EUR 616.00
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H3F3A Protein 

E35003
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H4 Protein 

E35005
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SOD1 Protein 

E70000
  • EUR 599.40
  • EUR 365.20
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EpiMag HT (96-Well) Magnetic Separator

Q10002
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EpiMag 96-Well Microplate (5/pack) 

Q10003
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Human Genomic DNA 

X11000
  • Ask for price
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Human Brain Genomic DNA  

X11001
  • Ask for price
  • EUR 77.00
  • 10 µg
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SCA-1 Antibody

47996-100ul 100ul
EUR 399.6

SCA-1 Antibody

47996-50ul 50ul
EUR 286.8

SCF Stem Cell Factor Human Recombinant Protein

PROTP21583-1 Regular: 10ug
EUR 380.4
Description: Stem Cell Factor Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids and having a molecular mass of 18409 Dalton. ;The SCF is purified by proprietary chromatographic techniques.

StemBoost? Neural Stem Cell Reprogramming Cocktail (100X)

S238-1
EUR 222

Human Prostate stem cell antigen (PSCA)

1-CSB-YP018840HU
  • EUR 516.00
  • EUR 280.80
  • EUR 1809.60
  • EUR 770.40
  • EUR 1210.80
  • EUR 349.20
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Prostate stem cell antigen(PSCA) expressed in Yeast

Human Prostate stem cell antigen (PSCA)

1-CSB-EP018840HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Prostate stem cell antigen(PSCA) expressed in E.coli

Human Prostate stem cell antigen (PSCA)

1-CSB-EP018840HUa0
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Prostate stem cell antigen(PSCA) expressed in E.coli

Human Stem Cell Factor (SCF) AssayMax ELISA Kit

ES1001-1 96 Well Plate
EUR 475.2

ACE2, His-Tag Protein

E80019
  • EUR 612.70
  • EUR 1437.70
  • 20 ul
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SARS-CoV-2 Spike S1 (13-665) Protein, Fc Fusion, Avi-tag

E80020
  • EUR 635.80
  • EUR 4276.80
  • 100 ul
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SARS-CoV-2 Spike S1 (16-685) Protein, Avi-His-tag

E80021
  • EUR 635.80
  • EUR 4276.80
  • 100 ul
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SARS-CoV-2 Spike S1 (16-685) Protein, Fc Fusion, Avi-tag

E80022
  • EUR 635.80
  • EUR 4276.80
  • 100 ul
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SARS-CoV-2 Spike S1 RBD (V367F) Protein, Avi-His-tag

E80023
  • EUR 635.80
  • EUR 3934.70
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SARS-CoV-2 Spike S1 RBD Protein, Avi-His-tag

E80024
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  • EUR 4995.10
  • 100 ul
  • 1 ml

SARS-CoV-2 Spike S1 RBD Protein, Human Fc-Fusion, Avi-Tag

E80025
  • EUR 635.80
  • EUR 3934.70
  • 100 ul
  • 1 ml

SARS-CoV-2 Nucleocapsid Protein, Avi-His-tag

E80027
  • EUR 635.80
  • EUR 4087.60
  • 1 ml
  • 100 ul

Recombinant SARS-CoV-2 Spike Glycoprotein(S) (D614G), Partial

E80028
  • EUR 388.30
  • EUR 860.20
  • 20 ul
  • 100 ul

SCA-1 Conjugated Antibody

C47996 100ul
EUR 476.4

Anti-Periphilin 1 Antibody

A06996-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Periphilin 1 Antibody (PPHLN1) detection.tested for WB in Human, Mouse.

Anti-Lyl-1 Antibody

A07491-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Lyl-1 Antibody. Validated in IHC and tested in Human, Mouse, Rat.

Anti-GLI-1 Antibody

A07972-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for GLI-1 Antibody (ACSS1) detection. Tested with WB in Human, Mouse, Rat.

Anti-Cerebellin 1 Antibody

A09176-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Cerebellin 1 Antibody (CBLN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-DOC-1 Antibody

A09467-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for DOC-1 Antibody (CDK2AP1) detection. Tested with WB in Human, Mouse.

Anti-NPDC-1 Antibody

A12846-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for NPDC-1 Antibody (NPDC1) detection. Tested with WB in Human, Mouse, Rat.

Anti-ROBO-1 Antibody

A01530-1 100ug
EUR 546
Description: Rabbit Polyclonal ROBO-1 Antibody. Validated in IF, IHC, WB and tested in Human, Mouse, Rat.

Anti-Bag-1 Antibody

A02423-1 50 ul
EUR 476.4
Description: Rabbit Polyclonal Bag-1 Antibody. Validated in IP, IHC and tested in Bovine, Canine, Human, Mouse, Rat.

Anti-TUB 1 Antibody

A02917-1 100ug/vial
EUR 352.8

Anti-Dok-1 Antibody

A03039-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Dok-1 Antibody (DOK1) detection.tested for WB in Human, Mouse, Rat.

Anti-TFIIIB90-1 Antibody

A03761-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for TFIIIB90-1 Antibody (BRF1) detection.tested for WB in Human, Mouse.

Anti-Atrophin-1 Antibody

A03828-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Atrophin-1 Antibody (ATN1) detection. Tested with WB in Human, Mouse, Rat.

Anti-CNG-1 Antibody

A05494-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for CNG-1 Antibody (CNGA1) detection. Tested with WB in Human, Mouse, Rat.

Anti-PAI-1 Antibody

A00637-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for PAI-1 Antibody (SERPINE1) detection.tested for WB in Human, Mouse, Rat.

Anti-Flk-1 Antibody

A00901-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Flk-1 Antibody (KDR) detection.tested for WB in Human, Mouse.

Anti-EDG-1 Antibody

A01502-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for EDG-1 Antibody (S1PR1) detection.tested for WB in Human, Mouse, Rat.

Anti-PARP-1 Antibody

A00122-1 100ul
EUR 476.4
Description: Rabbit Polyclonal PARP-1 Antibody. Validated in ELISA, IP, IF, WB and tested in Human, Mouse.

Anti-Presenilin 1 Antibody

A00138-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Presenilin 1 Antibody (PSEN1) detection. Tested with WB, IHC in Human, Mouse, Rat.

Methylamp 96 DNA Modification Kit 

P-1008
  • EUR 416.70
  • EUR 253.00
  • 96 Samples
  • 96 Samples

Nucleic Acid Isolation Enhancer (Glycogen Solution) 

R-1001
  • EUR 164.40
  • EUR 75.90
  • 500 µl
  • 500 ul

Methylamp PCR Enhancer 

R-1002
  • EUR 185.28
  • EUR 90.20
  • 400 Reactions
  • 400 Reactions

Streptavidin: HRP Conjugate

R-1098
  • EUR 218.34
  • EUR 107.80
  • 0.5 ml
  • 0.5 ml

Streptavidin 

R-1100
  • EUR 237.48
  • EUR 121.00
  • 1 mg
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Protease Inhibitor Cocktail 

R-1101
  • EUR 176.58
  • EUR 79.20
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Streptavidin-Coated Strip Microwell Plate (Flat) 

R-1102
  • EUR 361.02
  • EUR 204.60
  • 5/pk
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DNA High Binding Solution

R-1103
  • EUR 267.06
  • EUR 140.80
  • 30 ml
  • 30 ml

DTT Solution 

R-1104
  • EUR 131.34
  • EUR 48.40
  • 1 ml, 500 mM
  • 1 ml, 500 mM

EpiQuik Nuclear Extraction Kit 

OP-0002
  • EUR 350.58
  • EUR 211.20
  • 100 Assays
  • 100 Extractions

Human Prostate stem cell antigen(PSCA) ELISA kit

1-CSB-EL018840HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Prostate stem cell antigen(PSCA) in samples from serum, plasma, tissue homogenates, cell lysates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Hemokinin 1 (mouse)

B5127-1 1 mg
EUR 385.2

Anti-HO-1 Monoclonal Antibody (HO-1-2)

M00253-1 1mg
EUR 476.4
Description: Mouse Monoclonal HO-1 Antibody (HO-1-2). Validated in Flow Cytometry, IHC, WB and tested in Human, Mouse, Rat.

CF543 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20325-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF350 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20245-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF488A Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20246-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF555 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20247-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF568 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20248-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF594 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20249-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF633 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20250-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF640R Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20251-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF647 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20252-1 50uL
EUR 178.8
Description: Minimum order quantity: 1 unit of 50uL

CF680 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20253-1 50uL
EUR 193.2
Description: Minimum order quantity: 1 unit of 50uL

CF770 Goat Anti-Mouse IgG1 (γ1), 2mg/mL

20254-1 50uL
EUR 193.2
Description: Minimum order quantity: 1 unit of 50uL

Anti-Pyrophosphatase 1/PPA1 Antibody

A07485-1 100ug/vial
EUR 400.8

Anti-TCP-1 eta Antibody

A08169-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for TCP-1 eta Antibody (CCT7) detection. Tested with WB in Human, Mouse, Rat.

Anti-Relaxin 1/RLN1 Antibody

A08367-1 100ug/vial
EUR 400.8

Anti-TCP-1 zeta Antibody

A09373-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for TCP-1 zeta Antibody (CCT6A) detection.tested for WB in Human, Mouse, Rat.

Anti-CHST8/Galnac4St 1 Antibody

A10989-1 100ul
EUR 476.4
Description: Rabbit Polyclonal CHST8/Galnac4St 1 Antibody. Validated in WB and tested in Human, Mouse, Rat.

Anti-Synaptotagmin 1/SYT1 Antibody

A02314-1 100ug/vial
EUR 400.8

Anti-Syntenin-1 Monoclonal Antibody

A02475-1 100ul
EUR 476.4
Description: Mouse Monoclonal Antibody for Syntenin-1 Antibody (SDCBP) detection. Tested with WB in Human, Rat, Dog, Pig.

Anti-Dsg1/Desmoglein 1 Antibody

A02655-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for Dsg1 Antibody (DSG1) detection.tested for IHC, WB in Human, Mouse, Rat.

Anti-CAF-1 p150 Antibody

A02732-1 100ul
EUR 476.4
Description: Rabbit Polyclonal Antibody for CAF-1 p150 Antibody (CHAF1A) detection. Tested with WB in Human, Mouse.

Anti-Talin 1/TLN1 Antibody

A02859-1 100ug/vial
EUR 400.8

Anti-Islet 1/ISL1 Antibody

A02969-1 100ug/vial
EUR 400.8

Anti-Musashi 1/Msi1 Antibody

A05052-1 100ug/vial
EUR 400.8
Additional evaluation confirmed that mC-1 of SLC4A11 and MFSD3 was situated in transcription issue binding websites for NF-1 and Sp1. Our findings revealed the novel organic capabilities of porcine SLC4A11 and MFSD3 genes in regulating the cytotoxic results induced by DON, and will contribute to the detection of biomarkers and drug targets for predicting and eliminating the potential toxicity of DON.

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