Regardless of the unequivocal success of hematopoietic stem and progenitor cell gene remedy, limitations nonetheless exist together with genotoxicity and variegation/silencing of transgene expression. A category of DNA regulatory components often known as chromatin insulators (CI) can mitigate each, vector transcriptional silencing (barrier CIs) and vector-induced genotoxicity (enhancer-blocking CIs) and have been proposed as genetic modulators to attenuate undesirable vector-genome interactions. Just lately, plenty of human, small-sized and compact CIs bearing sturdy enhancer-blocking exercise had been recognized. To finally uncover an excellent CI with a twin, enhancer-blocking and barrier exercise, we interrogated these components in vitro and in vivo.
After preliminary screening of a collection of those enhancer-blocking insulators for potential barrier exercise, we recognized three distinct classes with no, partial or full safety towards transgene silencing. Subsequently, the 2 CIs with full barrier exercise (B4 and C1) had been examined for his or her potential to guard towards place results in main cells, after incorporation into lentiviral vectors and transduction of human CD34+ cells.
B4 and C1 didn’t adversely have an effect on vector titers resulting from their small dimension whereas they carried out as sturdy barrier insulators in CD34+cells, each in vitro and in vivo, shielding transgene’s long-term expression, extra robustly when positioned within the ahead orientation. Total, the incorporation of those dual-functioning components into therapeutic viral vectors will doubtlessly present a brand new era of safer and extra environment friendly lentiviral vectors for all hematopoietic stem cell gene remedy functions.
Single and double hit occasions in genes encoding for immune targets earlier than and after T cell participating antibody remedy in MM
T-cell participating immunotherapies exert unprecedented single-agent exercise in A number of Myeloma (MM), thereby placing a but unexplored selective stress on the clonal structure. On this examine, we report on homozygous BCMA (TNFRSF17) gene deletion after BCMA focusing on T-cell redirecting bispecific antibody remedy in a closely pretreated MM affected person. Lack of BCMA protein expression continued over subsequent relapses, with no response to anti-BCMA antibody drug conjugate (ADC) remedy.
In gentle of the a number of various targets that at the moment emerge along with BCMA, we prolonged our analyses to delineate a extra full image of genetic alterations that will influence immuno-therapy targets in MM. We carried out WGS and RNAseq in 100 MM sufferers (50 NDMM and 50 RRMM) and recognized a big proportion of sufferers with aberrations in genes encoding for immunotherapy targets, and GPRC5D ranked first with 15% heterozygous deletions, adopted by CD38 (10%), SDC1 (5%) and TNFRSF17 (4%).
Notably, these heterozygous deletions didn’t decrease the expression ranges of respective genes, however could symbolize a ‘first hit’ that drives the acquisition of homozygous deletions and, subsequent antigen-loss relapse upon focused immunotherapy. In abstract, we present pre-existing vulnerability in genes encoding for immuno-targets previous to and homozygous deletions after T-cell participating immunotherapy.
Leveraging the genetic variety of human stem cells in therapeutic approaches
Since their discovery 15 years in the past, human pluripotent stem cell (hPSC) applied sciences have begun to revolutionize science and drugs, quickly increasing past investigative analysis to drug discovery and growth. Efforts to leverage hPSCs over the past decade have centered on growing each the complexity and in vivo constancy of human mobile fashions by enhanced differentiation strategies.
Whereas these evolutions have fostered novel insights into illness mechanisms and influenced scientific drug discovery and growth, there are nonetheless a number of concerns that restrict the utility of hPSC fashions. On this overview, we spotlight essential, but underexplored avenues to broaden their attain. We concentrate on (i) the significance of diversifying current hPSC collections, and their utilization to research therapeutic methods in people from completely different genetic backgrounds, ancestry and intercourse; (ii) concerns for the choice of therapeutically related hPSC-based fashions; iii) methods to adequately improve the size of cell-based research; and iv) the advances and constraints of clinal trials in a dish.
Furthermore, we advocate for harnessing the translational capabilities of hPSC fashions together with using progressive, scalable approaches for understanding genetic biases and the influence of intercourse and ancestry on illness mechanisms and drug efficacy and response. The subsequent decade of hPSC innovation is poised to supply huge insights into the genetic foundation of human illness and allow speedy advances to develop, repurpose, and make sure the security of the subsequent era of illness therapies throughout numerous human populations.
Improvement and Characterization of Excessive Efficacy Cell-Penetrating Peptide through Modulation of the Histidine and Arginine Ratio for Gene Remedy
Cell-penetrating peptides (CPPs), as non-viral gene supply vectors, are thought of with decrease immunogenic response, and safer and better gene capability than viral programs. In our earlier examine, a CPP peptide referred to as RALA (arginine wealthy) introduced fascinating transfection efficacy and owns a possible clinic use. It’s believed that histidine may improve the endosome escaping potential of CPPs, but RALA peptide accommodates just one histidine in every chain.
With the intention to develop novel superior CPPs, through the use of RALA as a mannequin, we designed a collection of peptides named HALA (elevated histidine ratio). Each plasmid DNA (pDNA) and siRNA transfection outcomes on three cell traces revealed that the transfection efficacy is best when histidine replacements had been on the C-terminal as an alternative of on the N-terminal, and two histidine replacements are superior to 3.
PTPN11 (Ab-580) Antibody |
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| CSB-PA961746-100ul | Cusabio | 100ul | EUR 379.2 |
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Description: A polyclonal antibody against PTPN11 (Ab-580). Recognizes PTPN11 (Ab-580) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 |
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MemBriteâ„¢ Fix 568/580 |
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| 30095 | Biotium | 1KIT | EUR 772.8 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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hsa-miR-580 Primers |
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| MPH01878 | ABM | 150 ul / 10 uM | EUR 145.2 |
PTPN11 (Ab-580) Antibody |
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| CSB-PA961746- | Cusabio | each | EUR 402 |
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Description: A polyclonal antibody against PTPN11 (Ab-580). Recognizes PTPN11 (Ab-580) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC, IF;WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200 |
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Safflower yellow |
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| HY-N0938 | MedChemExpress | 50mg | EUR 159.6 |
SHP-2 (Ab-580) Antibody |
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| 21320-100ul | SAB | 100ul | EUR 302.4 |
SHP-2 (Ab-580) Antibody |
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| 21320-50ul | SAB | 50ul | EUR 224.4 |
PYK2 (Phospho-Tyr579/580) Antibody |
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| 13230-100ul | SAB | 100ul | EUR 302.4 |
PYK2 (Phospho-Tyr579/580) Antibody |
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| 13230-50ul | SAB | 50ul | EUR 224.4 |
anti-SHP-2 (Ab-580) |
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| LF-PA20454 | Abfrontier | 100 ul | EUR 400.8 |
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Description: Rabbit polyclonal to SHP-2 |
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hsa-miR-580 miRNA Inhibitor |
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| MIH03164 | ABM | 2 x 5.0 nmol | EUR 211.2 |
hsa-miR-580-3p Primers |
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| MPH03331 | ABM | 150 ul / 10 uM | EUR 145.2 |
hsa-miR-580-5p Primers |
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| MPH03332 | ABM | 150 ul / 10 uM | EUR 145.2 |
hsa-miR-580 miRNA Antagomir |
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| MNH03164 | ABM | 2 x 5.0 nmol | EUR 394.8 |
mFluor™ Blue 580 SE |
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| 1178 | AAT Bioquest | 1 mg | EUR 318 |
DIPAK LONG |
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| CPDI000L1 | Scientific Laboratory Supplies | EACH | EUR 304.62 |
Serpin A1c Recombinant Protein |
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| 91-580 | ProSci | 0.05 mg | EUR 821.4 |
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Description: Alpha-1-antitrypsin 1-3(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein have been found for this gene. |
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Kallikrein 7 Recombinant Protein |
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| 92-580 | ProSci | 0.05 mg | EUR 821.4 |
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Description: Kallikrein7, also named as stratum corneum chymotryptic enzyme (SCCE), is a secreted protein of the Kallikrein-related peptidase (KLK) family. This family contains fifteen homologous secreted serine endopeptidases and plays a significant role in various physiological processes, including skin desquamation, semen liquefaction, neural plasticity, and body fluid homeostasis. In skin KLK5, KLK 7 and KLK14 are able to degrade corneodesmosomes, which leads to desquamation of skin surface cells. KLK activation is believed to be mediated through highly organized proteolytic cascades, regulated through a series of feedback loops, inhibitors, auto-degradation and internal cleavages. Studies have shown that one potential physiological activator for KLK7 is KLK5. Along with KLK14, these three kallikreins form a proteolytic cascade in the stratum corneum. KLK7 is primarily expressed in the skin but is also detected at relatively high levels in esophagus, heart, liver, central nervous system, kidney, pancreas, mammary and salivary glands. |
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Sunset Yellow (BSA) |
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| 20-abx165822 | Abbexa |
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Sunset Yellow (OVA) |
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| 20-abx165823 | Abbexa |
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Alizarin yellow GG |
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| AB0011 | Bio Basic | 25g | EUR 70.44 |
Alizarin yellow R |
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| AB0012 | Bio Basic | 25g | EUR 70.44 |
C.I.Vat Yellow 2 |
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| 20-abx181248 | Abbexa |
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Pigment Yellow 42 |
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| abx185544-100g | Abbexa | 100 g | EUR 427.2 |
lucifer yellow cadaverine |
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| 80018 | Biotium | 25MG | EUR 178.8 |
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Description: Minimum order quantity: 1 unit of 25MG |
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Alcian Yellow Solution |
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| ANY125 | ScyTek Laboratories | 125 ml | EUR 99.6 |
Alcian Yellow Solution |
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| ANY3800 | ScyTek Laboratories | 1 Gal. | EUR 544.8 |
Alcian Yellow Solution |
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| ANY500 | ScyTek Laboratories | 500 ml | EUR 147.6 |
Alcian Yellow Solution |
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| ANY999 | ScyTek Laboratories | 1000 ml | EUR 213.6 |
0.6ML MICROTUBES. YELLOW |
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| MCT-060-Y | CORNING | 1000/pk | EUR 219.6 |
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Description: Micro Tubes; Micro Tubes Push Cap- Axygen |
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1.7ML MICROTUBES. YELLOW |
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| MCT-175-Y | CORNING | 500/pk | EUR 139.2 |
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Description: Micro Tubes; Micro Tubes Push Cap- Axygen |
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Hydroxysafflor yellow A |
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| N1526-20 | ApexBio | 20 mg | EUR 338.4 |
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Description: Extracted from Carthamus tinctorius L;Store the product in sealed,cool and dry condition |
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Sunset Yellow FCF |
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| HY-D0249 | MedChemExpress | 100mg | EUR 129.6 |
Hydroxysafflor yellow A |
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| HY-N0567 | MedChemExpress | 10mg | EUR 192 |
Naphthol Yellow S |
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| GT6579-100G | Glentham Life Sciences | 100 g | EUR 103.2 |
Naphthol Yellow S |
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| GT6579-250G | Glentham Life Sciences | 250 g | EUR 180 |
Naphthol Yellow S |
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| GT6579-25G | Glentham Life Sciences | 25 g | EUR 55.2 |
Sunset Yellow FCF |
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| GT7438-100G | Glentham Life Sciences | 100 g | EUR 132 |
Sunset Yellow FCF |
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| GT7438-25G | Glentham Life Sciences | 25 g | EUR 69.6 |
Basic Yellow 40 |
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| GT8545-25G | Glentham Life Sciences | 25 g | EUR 103.2 |
Anhydrosafflor yellow B |
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| TBW01543 | ChemNorm | 5mg | Ask for price |
200UL YELLOW TIPS |
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| T-200-Y | CORNING | 1000/pk | EUR 264 |
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Description: Non Filter Tips; Pipette Tips - Axygen |
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Safflor Yellow A |
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| TBZ2652 | ChemNorm | unit | Ask for price |
Labeling Tape, Yellow |
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| TP004Y | Bio Basic | 1ROLLS, 1 UNIT | EUR 64.42 |
Yellow Calibration Particles |
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| YCP-70-5 | Spherotech | 5 mL | EUR 388.8 |
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Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
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Simport Capinsert Yellow |
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| MIC2711 | Scientific Laboratory Supplies | PK500 | EUR 23.71 |
Tough 13mm Yellow |
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| MIC5020 | Scientific Laboratory Supplies | PK1000 | EUR 45.03 |
Simport Unirack Yellow |
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| RAC2110 | Scientific Laboratory Supplies | PK10 | EUR 49.7 |
Simport Slidefolder Yellow |
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| HIS0256 | Scientific Laboratory Supplies | PK10 | EUR 160.74 |
Simport Slidefile Yellow |
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| HIS0262 | Scientific Laboratory Supplies | PK10 | EUR 160.74 |
Simport Slidemailer Yellow |
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| HIS0272 | Scientific Laboratory Supplies | PK200 | EUR 80.94 |
Sharpsguard yellow 2.5ltr |
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| SAF7272 | Scientific Laboratory Supplies | PK48 | EUR 128.82 |
Capinsert 5.3mm Yellow |
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| CRY2068 | Scientific Laboratory Supplies | PK500 | EUR 40.36 |
Sharpsguard Yellow 3.75ltr |
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| DD474YL | Scientific Laboratory Supplies | PK48 | EUR 118.56 |
Yellow Petri seal |
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| DD53004 | Scientific Laboratory Supplies | EACH | EUR 83.22 |
Pouring Ring Yellow |
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| 1089917 | Scientific Laboratory Supplies | PK10 | EUR 7.98 |
Screw Cap - Yellow |
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| TUB1134 | Scientific Laboratory Supplies | PK3000 | EUR 128.82 |
Yellow Fluorescent Protein |
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| 4998-100 | Biovision | each | EUR 470.4 |
Yellow Fluorescent Protein |
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| 4998-1000 | Biovision | each | EUR 3015.6 |
Yellow Fluorescent Protein |
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| 4998-5000 | Biovision | each | EUR 8215.2 |
PYK2 (Phospho-Tyr579/580) Conjugated Antibody |
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| C13230 | SAB | 100ul | EUR 476.4 |
Phospho-PYK2 (Tyr579/580) Blocking Peptide |
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| AF7383-BP | Affbiotech | 1mg | EUR 234 |
Mesothelin / MSLN (296-580) Recombinant Protein |
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| 11-216 | ProSci | 0.1 mg | EUR 714.3 |
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Description: Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro. |
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MemBriteâ„¢ Fix 568/580, Trial Size |
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| 30095-T | Biotium | 1KIT | EUR 266.4 |
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Description: Minimum order quantity: 1 unit of 1KIT |
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DAX-J2™ Ratio 580/460 |
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| 16310 | AAT Bioquest | 1 mg | EUR 471.6 |
Zinc Finger Protein 580 (ZNF580) Antibody |
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| abx030431-400ul | Abbexa | 400 ul | EUR 627.6 |
Zinc Finger Protein 580 (ZNF580) Antibody |
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| abx030431-80l | Abbexa | 80 µl | EUR 343.2 |
Recombinant human Zinc finger protein 580 |
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| P2142 | FN Test | 100ug | Ask for price |
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Description: Recombinant protein for human Zinc finger protein 580 |
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hsa-miR-580-3p miRNA Inhibitor |
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| MIH03165 | ABM | 2 x 5.0 nmol | EUR 211.2 |
hsa-miR-580-5p miRNA Inhibitor |
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| MIH03166 | ABM | 2 x 5.0 nmol | EUR 211.2 |
hsa-miR-580-3p miRNA Antagomir |
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| MNH03165 | ABM | 2 x 5.0 nmol | EUR 394.8 |
hsa-miR-580-5p miRNA Antagomir |
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| MNH03166 | ABM | 2 x 5.0 nmol | EUR 394.8 |
Cell Strainer 100um Yellow Sterile Ind. Wrapped |
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| ARG1222 | Scientific Laboratory Supplies | PK50 | EUR 205.2 |
Long trebler phosphoramidite |
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| A8151-250 | ApexBio | 250 mg | EUR 408 |
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Description: Long trebler phosphoramidite is a branching reagent for oligonucleotide synthesis allowing to synthesize branched DNA structures using standard DNA synthesizer. |
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Wick 100mm Long |
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| BUR4508 | Scientific Laboratory Supplies | PK10 | EUR 6.27 |
Embedding Cassettes |
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| M480-5-YELLOW | ScyTek Laboratories | 1 ea. | EUR 232.8 |
Cassettes in QuickLoad Sleeves |
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| M480-5SL-YELLOW | ScyTek Laboratories | 1 ea. | EUR 340.8 |
CytoFix™ BCECF, AM *Optimized for long term cellular pH tracking* |
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| 21200 | AAT Bioquest | 1 mg | EUR 318 |
Sunset Yellow (SY) Antibody |
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| 20-abx100868 | Abbexa |
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Yellow Fever NS1 Antibody |
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| abx024098-1mg | Abbexa | 1 mg | EUR 927.6 |
Yellow Fever NS1 Antibody |
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| abx024122-1mg | Abbexa | 1 mg | EUR 927.6 |
Yellow Fever NS1 Antibody |
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| abx024123-1mg | Abbexa | 1 mg | EUR 927.6 |
Yellow Fever NS1 Antibody |
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| abx024124-1mg | Abbexa | 1 mg | EUR 927.6 |
Yellow Fever NS1 Antibody |
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| abx024125-1mg | Abbexa | 1 mg | EUR 927.6 |
Yellow Fever NS1 Antibody |
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| abx024126-1mg | Abbexa | 1 mg | EUR 927.6 |
Yellow Fever NS1 Antibody |
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| abx024127-1mg | Abbexa | 1 mg | EUR 927.6 |
Naphthol Yellow S Solution |
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| NYS125 | ScyTek Laboratories | 125 ml | EUR 121.2 |
Naphthol Yellow S Solution |
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| NYS500 | ScyTek Laboratories | 500 ml | EUR 204 |
Naphthol Yellow S Solution |
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| NYS999 | ScyTek Laboratories | 1000 ml | EUR 290.4 |
Metanil Yellow (Aqueous Solution) |
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| MYQ500 | ScyTek Laboratories | 500 ml | EUR 117.6 |
Metanil Yellow (Aqueous Solution) |
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| MYQ999 | ScyTek Laboratories | 1000 ml | EUR 152.4 |
Fluorescent Light Yellow Particles |
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| FP-15045-2 | Spherotech | 2 mL | EUR 339.6 |
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Description: Please reffer to the technical data sheet for more detail information for this item. Our dedicated team would be happy to assist you via live chat, email or phone. |
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Martius Yellow (C.I. 10315) |
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| GL3107-100G | Glentham Life Sciences | 100 g | EUR 237.6 |
Martius Yellow (C.I. 10315) |
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| GL3107-25G | Glentham Life Sciences | 25 g | EUR 108 |
Metanil Yellow (C.I. 13065) |
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| GT1665-100G | Glentham Life Sciences | 100 g | EUR 84 |
Metanil Yellow (C.I. 13065) |
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| GT1665-250G | Glentham Life Sciences | 250 g | EUR 132 |
Metanil Yellow (C.I. 13065) |
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| GT1665-50G | Glentham Life Sciences | 50 g | EUR 64.8 |
Alcian Yellow (C.I. 12840) |
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| GT4246-1G | Glentham Life Sciences | 1 g | EUR 160.8 |
Dimethyl Yellow (C.I. 11020) |
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| GT5992-100G | Glentham Life Sciences | 100 g | EUR 108 |
Dimethyl Yellow (C.I. 11020) |
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| GT5992-25G | Glentham Life Sciences | 25 g | EUR 64.8 |
Dimethyl Yellow (C.I. 11020) |
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| GT5992-500G | Glentham Life Sciences | 500 g | EUR 228 |
Quinoline Yellow (C.I. 47000) |
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| GT7040-100G | Glentham Life Sciences | 100 g | EUR 141.6 |
Quinoline Yellow (C.I. 47000) |
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| GT7040-250G | Glentham Life Sciences | 250 g | EUR 237.6 |
Quinoline Yellow (C.I. 47000) |
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| GT7040-25G | Glentham Life Sciences | 25 g | EUR 74.4 |
Nitrazine Yellow (C.I. 14890) |
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| GT9637-25G | Glentham Life Sciences | 25 g | EUR 255.6 |
Nitrazine Yellow (C.I. 14890) |
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| GT9637-5G | Glentham Life Sciences | 5 g | EUR 93.6 |
80-Well Rack, Yellow |
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| R567-Y | Bio Basic | 1 UNIT | EUR 63.01 |
Hydroxy safflor Yellow A |
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| TB0782-1000 | ChemNorm | 20mg | EUR 248.4 |
200UL YELLOW TIPS, RACKED |
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| T-200-Y-R | CORNING | 960/pk | EUR 150 |
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Description: Non Filter Tips; Pipette Tips - Axygen |
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200UL YELLOW REFERENCE TIPS |
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| TR-222-Y | CORNING | 1000/pk | EUR 255.6 |
|
Description: Non Filter Tips; Pipette Tips - Axygen |
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YELLOW Lysis Kit 50 |
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| YELLOWE1 | Next Advance | 50pack | EUR 210 |
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Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 50, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. |
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YELLOW Lysis Kit 250 |
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| YELLOWE5 | Next Advance | 250pack | EUR 657.6 |
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Description: Bead lysis kits for the homogenization of small cell suspensions (ex - E. coli). Pack of 250, 1.5mL Eppendorf Safe-Lock tubes prefilled with stabilized ceramic beads. |
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adapt-a-rack Yellow |
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| RAC0142 | Scientific Laboratory Supplies | PK2 | EUR 19.13 |
Simport Embedding Cassette Yellow |
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| HIS0012 | Scientific Laboratory Supplies | PK1500 | EUR 208.62 |
Simport Embedding Cassette Yellow |
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| HIS0046 | Scientific Laboratory Supplies | PK1500 | EUR 238.26 |
Simport Embedding Cassette Yellow |
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| HIS0057 | Scientific Laboratory Supplies | PK1500 | EUR 251.94 |
Simport Embedding Cassette Yellow |
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| HIS0090 | Scientific Laboratory Supplies | PK1000 | EUR 168.72 |
Simport Embedding Cassette Yellow |
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| HIS0101 | Scientific Laboratory Supplies | PK1000 | EUR 213.18 |
Simport Embedding Cassette Yellow |
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| HIS0112 | Scientific Laboratory Supplies | PK1000 | EUR 427.5 |
Simport Embedding Cassette Yellow |
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| HIS0123 | Scientific Laboratory Supplies | PK1000 | EUR 427.5 |
Simport Embedding Cassette Yellow |
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| HIS0156 | Scientific Laboratory Supplies | PK2000 | EUR 435.48 |
Simport Embedding Lid Yellow |
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| HIS0167 | Scientific Laboratory Supplies | PK2000 | EUR 133.38 |
Simport Embedding Cassette Yellow |
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| HIS0178 | Scientific Laboratory Supplies | PK2000 | EUR 436.62 |
Simport Embedding Lid Yellow |
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| HIS0189 | Scientific Laboratory Supplies | PK2000 | EUR 133.38 |
Bolle SilexPSJ Yellow Lens |
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| SAF1906 | Scientific Laboratory Supplies | EACH | EUR 8.14 |
Sharpsbin 5Ltr - yellow lid |
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| SAF7273 | Scientific Laboratory Supplies | PK48 | EUR 184.68 |
Sharpsbin 7Ltr yellow lid |
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| SAF7274 | Scientific Laboratory Supplies | PK40 | EUR 205.2 |
Bio-bin 2ltr Yellow |
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| SAF7294 | Scientific Laboratory Supplies | EACH | EUR 1.94 |
Bio-bin 6ltr Yellow |
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| SAF7296 | Scientific Laboratory Supplies | EACH | EUR 10.03 |
Bio bin 1ltr Yellow |
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| SAF7405 | Scientific Laboratory Supplies | EACH | EUR 1.71 |
Bio bin 5ltr Yellow |
|||
| SAF7434 | Scientific Laboratory Supplies | PK100 | EUR 182.4 |
Bio-bin Loop Yellow |
|||
| SAF7616 | Scientific Laboratory Supplies | PK100 | EUR 136.8 |
Bio-bin 30Ltr Yellow |
|||
| SAF7618 | Scientific Laboratory Supplies | PK10 | EUR 68.4 |
Simport Capinsert T312 Yellow |
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| CRY2266 | Scientific Laboratory Supplies | PK500 | EUR 19.72 |
Nalgene Yellow Cap Coder |
|||
| CRY8212 | Scientific Laboratory Supplies | PK100 | EUR 19.38 |
200ul Tip Yellow Generic |
|||
| DD017020AA | Scientific Laboratory Supplies | PK1000 | EUR 27.02 |
Cap GL45 yellow colour |
|||
| DD46101 | Scientific Laboratory Supplies | PK10 | EUR 26.45 |
Ring 45 yellow colour |
|||
| DD46108 | Scientific Laboratory Supplies | PK10 | EUR 8.32 |
WYPALL X80 Cloths Yellow |
|||
| CLE7028 | Scientific Laboratory Supplies | PK250 | EUR 188.1 |
Tweezers Azlon Yellow 180mm |
|||
| TWY264 | Scientific Laboratory Supplies | EACH | EUR 9.42 |
Onerack 16mm tubes Yellow |
|||
| STA5042 | Scientific Laboratory Supplies | EACH | EUR 24.28 |
Onerack 30mm tubes Yellow |
|||
| STA5044 | Scientific Laboratory Supplies | EACH | EUR 31.92 |
Onerack 13mm tubes Yellow |
|||
| STA5140 | Scientific Laboratory Supplies | EACH | EUR 20.43 |
DuraPorter Transport Box Yellow |
|||
| STO0003 | Scientific Laboratory Supplies | EACH | EUR 135.66 |
CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Colorimetric |
|||
| CBA-135 | Cell Biolabs | 96 assays | EUR 985.2 |
|
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis. |
|||
CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Colorimetric |
|||
| CBA-135-5 | Cell Biolabs | 5 x 96 assays | EUR 4027.2 |
|
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis. |
|||
CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Fluorometric |
|||
| CBA-140 | Cell Biolabs | 96 assays | EUR 1027.2 |
|
Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis. |
|||
CytoSelect Cell Transformation Assay (Cell Recovery Compatible), Fluorometric |
|||
| CBA-140-5 | Cell Biolabs | 5 x 96 assays | EUR 4179.6 |
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Description: CytoSelect 96-Well Cell Transformation Assays (Cell Recovery Compatible) provide a robust system for detecting transformed cells, screening cell transformation inhibitors, and determining in vitro drug sensitivity. A proprietary modified soft agar matrix allows you to either quantify cells using the included fluorescent dye, or recover the cells for further analysis. |
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293AD Cell Line |
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| AD-100 | Cell Biolabs | 1 vial | EUR 553.2 |
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Description: The 293AD Cell Line is derived from the parental 293 cells but selected for attributes that increase adenovirus production, including firmer attachment and larger surface area. |
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293AAV Cell Line |
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| AAV-100 | Cell Biolabs | 1 vial | EUR 609.6 |
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Description: The 293AAV Cell Line is derived from the parental 293 cells but selected for attributes that increase AAV production, including firmer attachment and larger surface area. |
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293LTV Cell Line |
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| LTV-100 | Cell Biolabs | 1 vial | EUR 609.6 |
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Description: The 293LTV Cell Line is derived from the parental 293 cells but selected for attributes that increase lentiviral production, including fimrer attachment and larger surface area. |
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293RTV Cell Line |
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| RV-100 | Cell Biolabs | 1 vial | EUR 609.6 |
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Description: The 293RTV Cell Line is derived from the parental 293 cells but selected for attributes that increase retroviral production, including fimrer attachment and larger surface area. |
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Human B Cell Leukemia X long ELISA kit |
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| E01B0575-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Human B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human B Cell Leukemia X long ELISA kit |
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| E01B0575-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Human B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Human B Cell Leukemia X long ELISA kit |
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| E01B0575-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Human B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat B Cell Leukemia X long ELISA kit |
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| E02B0575-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Rat B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat B Cell Leukemia X long ELISA kit |
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| E02B0575-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Rat B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Rat B Cell Leukemia X long ELISA kit |
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| E02B0575-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Rat B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig B Cell Leukemia X long ELISA kit |
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| E07B0575-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Porcine B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig B Cell Leukemia X long ELISA kit |
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| E07B0575-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Porcine B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Pig B Cell Leukemia X long ELISA kit |
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| E07B0575-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Porcine B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog B Cell Leukemia X long ELISA kit |
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| E08B0575-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Canine B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog B Cell Leukemia X long ELISA kit |
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| E08B0575-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Canine B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Dog B Cell Leukemia X long ELISA kit |
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| E08B0575-96 | BlueGene | 1 plate of 96 wells | EUR 822 |
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Description: A competitive ELISA for quantitative measurement of Canine B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey B Cell Leukemia X long ELISA kit |
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| E09B0575-192T | BlueGene | 192 tests | EUR 1524 |
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Description: A competitive ELISA for quantitative measurement of Monkey B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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Monkey B Cell Leukemia X long ELISA kit |
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| E09B0575-48 | BlueGene | 1 plate of 48 wells | EUR 624 |
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Description: A competitive ELISA for quantitative measurement of Monkey B Cell Leukemia X long in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species. |
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By investigating the mechanism of endocytosis of the pDNA nanocomplexes, we found that there have been a number of pathways that led to the method and caveolae performed the principle position. Through the screening, we found a novel peptide-HALA2 of excessive mobile transfection efficacy, which can act as an thrilling gene supply vector for gene remedy. Our findings additionally carry new insights on the event of novel strong CPPs.