Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics

Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics

Basal cell carcinoma (BCC) is a major public well being concern, with greater than three million circumstances occurring every year in america, and with an growing incidence. The molecular foundation of BCC is advanced, involving an interaction of inherited genetic susceptibility, together with single nucleotide polymorphisms and genetic syndromes, and sporadic somatic mutations, typically induced by carcinogenic publicity to UV radiation.
This overview outlines the presently recognized germline and somatic mutations implicated within the pathogenesis of BCC, together with the important thing molecular pathways affected by these mutations, which drive oncogenesis. With advances in subsequent era sequencing and our understanding of the molecular genetics of BCC, established and rising focused therapeutics are providing new avenues for the non-surgical remedy of BCC. These brokers, together with Hedgehog pathway inhibitors, immune modulators, and histone deacetylase inhibitors, may even be mentioned.

XIAP gene remedy results on retinal ganglion cell construction and performance in a mouse mannequin of glaucoma

Glaucoma is a prevalent neurodegenerative illness that’s characterised by progressive visible discipline loss. It’s the main reason for irreversible blindness on the planet. The primary danger issue for glaucoma is elevated intraocular stress that leads to the injury and loss of life of retinal ganglion cells (RGCs) and their axons. The loss of life of RGCs has been proven to be apoptotic. We examined the speculation that blocking the activation of apoptosis could also be an efficient technique to forestall RGC loss of life and protect practical imaginative and prescient in glaucoma.
Within the magnetic microbead mouse mannequin of induced ocular hypertension, inhibition of RGC apoptosis was focused via viral-mediated ocular supply of the X-linked inhibitor of apoptosis (XIAP) gene, a potent caspase inhibitor. Sample electroretinograms revealed that XIAP remedy resulted in important safety of each somal and axonal RGC operate in glaucomatous eyes. Histology confirmed that the handled optic nerves confirmed preservation of axon counts and decreased glial cell infiltration. These outcomes present that XIAP is ready to present each practical and structural safety of RGCs within the microbead mannequin of glaucoma and supply vital proof-of-principle for XIAP’s efficacy as a neuroprotective remedy for glaucoma.

Major Mediastinal B-Cell Lymphoma: A 2021 Replace on Genetics, Prognosis, and Novel Therapeutics

Major mediastinal massive B-cell lymphoma (PMBCL) is an aggressive B-cell lymphoma arising from thymic B-cells having clinicopathologic options distinct from systemic diffuse massive B-cell lymphoma (DLBCL). PMBCL contains 2% to 4% of all non-Hodgkin lymphomas (NHL), 7% of DLBCL and seen predominantly in younger females with a median age of 35 years at analysis. The annual incidence of PMBCL is 0.Four per million with a 5-year survival charge exceeding 70% with enhancing supportive care and genetic characterization of the illness.
 Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics
Pathogenesis entails dysregulation of Janus kinase-signal transducer and activator of transcription (JAK-STAT), nuclear factor-kB (NF-kB) pathways and amplification of the 9p24.1 area of chromosome 9. PMBCL sufferers have a protracted life expectancy necessitating the necessity for remedy approaches which can be based mostly on maximizing remedy with minimal long-term toxicity. Because of rarity and its recognition as a definite entity, therapeutic choices are guided by medical presentation, clinician and heart expertise, and evaluation of sufferers with PMBCL inside DLBCL registries.
Traditionally R-CHOP has been the standard first line remedy for PMBCL adopted by concerned web site radiotherapy (ISRT), nonetheless medical observe varies throughout facilities with rising consensus to keep away from upfront RT by using dose intense regimens (DA-EPOCH-R) in youthful and match sufferers. Prognosis of relapsed refractory PMBCL not responding to salvage chemotherapy is dismal, nonetheless there are a lot of rising choices together with Brentuximab Vedotin, immune examine level inhibitors and chimeric antigen receptor T-cell remedy. On this article, we concentrate on the pathogenesis, present and evolving therapies, and supply suggestions for optimum administration of sufferers with PMBCL.

PE38-based gene remedy of HER2-positive breast most cancers stem cells by way of VHH-redirected polyamidoamine dendrimers

Breast most cancers stem cells (BCSCs) resist standard therapies and trigger tumor recurrence. Nearly 25% of breast cancers overexpress human epidermal development issue receptor-2 (HER2). Right here we developed a novel multi-targeted nanosystem to particularly eradicate HER2+ BCSCs. Plasmids containing CXCR1 promoter, PE38 toxin, and 5’UTR of the fundamental fibroblast development factor-2 (bFGF 5’UTR) had been constructed. Polyamidoamine (PAMAM) dendrimers functionalized with anti-HER2 VHHs had been used for plasmid supply.
Stem cell proportion of MDA-MB-231, MDA-MB-231/HER2+ and MCF-10A had been evaluated by mammosphere formation assay. Hanging drop method was used to supply spheroids. The uptake, gene expression, and killing efficacy of the multi-targeted nanosystem had been evaluated in each monolayer and spheroid tradition. MDA-MB-231/HER2+ had increased capability to kind mammosphere in comparison with MCF-10A.
Our multi-targeted nanosystem effectively inhibited the mammosphere formation of MDA-MB-231 and MDA-MB-231/HER2+ cells, whereas it was unable to forestall the mammosphere formation of MCF-10A. Within the hanging drop tradition, MDA-MB-231/HER+ generated compact well-rounded spheroids, whereas MCF-10A did not kind compact mobile plenty.

Human Betacellulin ELISA Kit

IHUBTCKT each
EUR 702
Description: Human Betacellulin ELISA Kit

Recombinant Human Betacellulin

7-00223 5µg Ask for price

Recombinant Human Betacellulin

7-00224 20µg Ask for price

Recombinant Human Betacellulin

7-00225 1mg Ask for price

Human Betacellulin (Recombinant)

22060316-1 5 µg
EUR 146.42

Recombinant Human Betacellulin

AP60110 100ug
EUR 896

Recombinant Human BetaCellulin

HEOPP-0212 5ug Ask for price

Recombinant Human Betacellulin

cyt-330-1mg 1mg
EUR 2700

Recombinant Human Betacellulin

cyt-330-20g 20µg
EUR 145

Recombinant Human Betacellulin

cyt-330-5g 5µg
EUR 60

Betacellulin (Human) ELISA Kit

EKA51822-5x96T 5x96T Ask for price

Betacellulin (Human) ELISA Kit

EKA51822-96T 96T
EUR 446.9

Betacellulin Human Recombinant

rAP-0363 Inquiry Ask for price

Human Betacellulin (bTC) Protein

20-abx065524
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Betacellulin (bTC) Protein

abx065524-100g 100 µg
EUR 537.5

Human Betacellulin (bTC) Protein

abx065524-10g 10 µg
EUR 212.5

Human Betacellulin (bTC) Protein

abx065524-50g 50 µg
EUR 375

Anti-Mouse Betacellulin Antibody

103-M308 100 µg
EUR 399
Description: Betacellulin (BTC) is a new member of the EGF family of cytokines that is comprised of at least ten proteins including EGF, TGFα, amphiregulin, HB-EGF, and the various heregulins. All of these cytokines are synthesized as transmembrane precursors and are characterized by the presence of one or more EGF structural units in their extracellular domain. The soluble forms of these cytokines are released by proteolytic cleavage. BTC, a heparin binding protein, was originally isolated from the conditioned media of mouse pancreatic beta tumor cells as a 32 kDa glycoprotein composed of 80 amino acid residues. The cDNA encoding human BTC was cloned from a human breast adenocarcinoma cell line (MCF7) cDNA library. Human and mouse cDNAs encode BTC precursor proteins of 178 and 177 amino acid residues, respectively. At the amino acid sequence level, human BTC precursor protein exhibits 79% identity with that of the mouse BTC precursor. In a mouse cell line transfected with human BTC cDNA, three forms of soluble human BTC have been detected: the glycosylated, intact BTC composed of 80 amino acid residues, a truncated molecule lacking 12 amino acid residues from the amino terminus, and a second truncated molecule lacking 30 amino acid residues from the amino-terminus. The biological activities of these BTC forms were shown to be identical. BTC can bind to the EGF receptor and is a potent mitogen for Balb/c 3T3 fibroblasts, retinal pigment epithelial cells and vascular smooth muscle cells.

Human Betacellulin GENLISA ELISA

KB1015 1 x 96 wells
EUR 198

Human Betacellulin (BTC) CLIA Kit

20-abx491043
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Betacellulin (bTC) CLIA Kit

abx196482-96tests 96 tests
EUR 990

Human Betacellulin (bTC) CLIA Kit

abx196482-100l 100 µl Ask for price

Human Betacellulin (bTC) CLIA Kit

abx196482-50l 50 µl
EUR 618.75

Betacellulin antibody

70R-BR013 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal Betacellulin antibody

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu 96T
EUR 422
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin/BTC ELISA kit

E22-HC017.48 48T
EUR 295

Human Betacellulin/BTC ELISA kit

E22-HC017.96 96T
EUR 395

Human Betacellulin/BTC ELISA Kit

EK5454 96 tests
EUR 599

Human Betacellulin (bTC) ELISA Kit

EKN43808-48T 48T
EUR 341.04

Human Betacellulin (bTC) ELISA Kit

EKN43808-5x96T 5x96T
EUR 2314.2

Human Betacellulin (bTC) ELISA Kit

EKN43808-96T 96T
EUR 487.2

Human Betacellulin (bTC) ELISA Kit

EKU02697-48T 48T
EUR 500.5

Human Betacellulin (bTC) ELISA Kit

EKU02697-5x96T 5x96T
EUR 3396.25

Human Betacellulin (bTC) ELISA Kit

EKU02697-96T 96T
EUR 715

Human Betacellulin (bTC) ELISA Kit

DL-bTC-Hu 96T
EUR 402
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin, BTC ELISA Kit

DEIA089 10 plates
EUR 3126
Description: This assay is a sandwich Enzyme Linked-Immuno-Sorbent Assay (ELISA). It is developed for quantitative measurement of human BTC in serum, plasma and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

EK12923 96Т
EUR 768

Human Betacellulin (BTC) ELISA Kit

abx570040-96tests 96 tests
EUR 801.6

Human Betacellulin (BTC) ELISA Kit

abx250182-96tests 96 tests
EUR 801.6

Human Betacellulin/BTC ELISA Kit

LF-EK50996 1×96T
EUR 777.6

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-48T 48T
EUR 432.39
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-48Tests 48 Tests
EUR 600

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-96T 96T
EUR 617.72
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-96Tests 96 Tests
EUR 830.4

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-48T 48T
EUR 411.8
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-48Tests 48 Tests
EUR 573.6

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-96T 96T
EUR 588.3
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-96Tests 96 Tests
EUR 794.4

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

4-SEA112Hu
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  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Betacellulin(BTC)ELISA Kit

YLA3880HU-48T 48T Ask for price

Human Betacellulin(BTC)ELISA Kit

YLA3880HU-96T 96T Ask for price

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-24Tests 24 Tests
EUR 180
Description: Sandwich

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-48Tests 48 Tests
EUR 546
Description: Sandwich

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-96Tests 96 Tests
EUR 682
Description: Sandwich

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Recombinant Human Betacellulin, HEK

cyt-1188-10g 10µg
EUR 145

Recombinant Human Betacellulin, HEK

cyt-1188-1mg 1mg
EUR 5200

Recombinant Human Betacellulin, HEK

cyt-1188-2g 2µg
EUR 60

Human Betacellulin Protein, Fc Tag

BEN-H525x 1mg
EUR 374.5
Description: Human Betacellulin, Fc Tag (BEN-H525x) is expressed from human 293 cells (HEK293). It contains AA Asp 32 - Tyr 111 (Accession # AAH11618).

Human bTC(Betacellulin) ELISA Kit

ELK1403-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human bTC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human bTC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human bTC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human bTC in the samples is then determined by comparing the OD of the samples to the standard curve.

Human bTC(Betacellulin) ELISA Kit

ELK1403-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human bTC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human bTC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human bTC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human bTC in the samples is then determined by comparing the OD of the samples to the standard curve.

Human BTC(Betacellulin) ELISA Kit

EH0044 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human BTC (Betacellulin) ELISA Kit

EKE60392-5x96T 5x96T
EUR 3124.08

Human BTC (Betacellulin) ELISA Kit

EKE60392-96T 96T
EUR 657.7

Human BTC(Betacellulin) ELISA Kit

RE2928H-48wells 48 wells
EUR 116.55

Human BTC(Betacellulin) ELISA Kit

RE2928H-96wells 96 wells
EUR 161.55

BTC (untagged)-Human betacellulin (BTC)

SC309035 10 µg Ask for price

Betacellulin, Mouse

HY-P7329 50ug
EUR 734.4

Bovine Betacellulin

ARU020 20 µg
EUR 303.6

Bovine Betacellulin

ARU100 100 µg
EUR 415.2

Human Betacellulin Recombinant Protein

100-332 20 µg
EUR 196.35
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Human Betacellulin Recombinant Protein

100-332S 5 µg
EUR 92.4
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Recombinant Human Betacellulin Protein

PROTP35070-2 20ug
EUR 380.4
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Nori® Human Betacellulin ELISA Kit

GR106276 96-well
EUR 461

Human Betacellulin (bTC) Protein (Active)

20-abx655563
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Betacellulin (bTC) Protein (Active)

abx655563-50g 50 µg
EUR 3712.5

CLIA kit for Human BTC (Betacellulin)

E-CL-H0444 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

Betacellulin (HEK293-expressed), Human

HY-P7328 10ug
EUR 280.8

Betacellulin (bTC) Polyclonal Antibody (Human)

4-PAA112Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC)

Betacellulin protein

30R-AB028 20 ug
EUR 312
Description: Purified recombinant Human Betacellulin protein

Sheep Polyclonal anti-human Betacellulin (BTC)

hAP-5047 50ug
EUR 400

Sheep Polyclonal anti-Human Betacellulin (BTC)

hAP-5649 50ug
EUR 400

BTC Antibody / Betacellulin

F54607-0.08ML 0.08 ml
EUR 140.25
Description: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. [UniProt]

BTC Antibody / Betacellulin

F54607-0.4ML 0.4 ml
EUR 322.15
Description: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. [UniProt]

Betacellulin (bTC) Antibody

20-abx100739
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody

20-abx100740
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody

20-abx175568
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  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175569
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  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175570
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  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175571
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  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx171411
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  • 1 mg
  • 200 ug

Betacellulin (BTC) Antibody

abx230883-100ug 100 ug
EUR 577.2

Betacellulin (BTC) Antibody

20-abx111218
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  • 150 ul
  • 50 ul

Betacellulin Antibody / BTC

RQ4417 100 ug
EUR 356.15
Description: Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.

BTC Antibody / Betacellulin

RQ4539 100ug
EUR 356.15
Description: Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.

Betacellulin (BTC) Antibody

abx230883-100g 100 µg
EUR 350

Betacellulin (BTC) Antibody

abx111218-100l 100 µl
EUR 612.5

Betacellulin (bTC) Antibody

abx100739-100l 100 µl
EUR 237.5

Betacellulin (bTC) Antibody

abx100739-1ml 1 ml
EUR 575

Betacellulin (bTC) Antibody

abx100739-200l 200 µl
EUR 287.5

Betacellulin (bTC) Antibody

abx100740-100l 100 µl
EUR 250

Betacellulin (bTC) Antibody

abx100740-1ml 1 ml
EUR 675

Betacellulin (bTC) Antibody

abx100740-200l 200 µl
EUR 312.5

Betacellulin (bTC) Antibody

abx175570-1096tests 10 × 96 tests Ask for price

Betacellulin (bTC) Antibody

abx175570-596tests 5 × 96 tests Ask for price

Betacellulin (bTC) Antibody

abx175570-96tests 96 tests
EUR 725

Betacellulin (bTC) Antibody

abx171411-100l 100 µl
EUR 712.5

Betacellulin (bTC) Antibody

abx171411-1ml 1 ml Ask for price

Betacellulin (bTC) Antibody

abx171411-200l 200 µl Ask for price

Recombinant Human Betacellulin, His Tag

cyt-077-10g 10µg
EUR 145

Recombinant Human Betacellulin, His Tag

cyt-077-1mg 1mg
EUR 5200

Recombinant Human Betacellulin, His Tag

cyt-077-2g 2µg
EUR 60

ELISA kit for Human BTC (Betacellulin)

E-EL-H0570 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human bTC (Betacellulin)

ELK1403 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Betacellulin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Rat Monoclonal anti-mouse Betacellulin

mAP-0154 100ug
EUR 250

Betacellulin Human Recombinant, His Tag

rAP-0361 Inquiry Ask for price

BTC (GFP-tagged) - Human betacellulin (BTC)

RG202483 10 µg Ask for price

Betacellulin (bTC) Polyclonal Antibody (Human), PE

4-PAA112Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with PE.

Human Betacellulin/BTC PicoKine ELISA Kit

EK0980 96 wells
EUR 510
Description: For quantitative detection of human Betacellulin in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Recombinant Human Betacellulin/BTC Protein

RP01700 10μg
EUR 162.5

Betacellulin (bTC) Polyclonal Antibody (Human), APC

4-PAA112Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with APC.

Betacellulin (bTC) Polyclonal Antibody (Human), Cy3

4-PAA112Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with Cy3.

Betacellulin (bTC) Polyclonal Antibody (Human), HRP

4-PAA112Hu01-HRP
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with HRP.

Anti-Human Betacellulin Rabbit Polyclonal Antibody

TA328270 100 µg Ask for price

Active Betacellulin (bTC)

RPU59143-100ug 100ug
EUR 1013.8

Active Betacellulin (bTC)

RPU59143-1mg 1mg
EUR 4212

Active Betacellulin (bTC)

RPU59143-50ug 50ug
EUR 673.2

Betacellulin (bTC) Polyclonal Antibody (Human), FITC

4-PAA112Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with FITC.

BTC Betacellulin Human Recombinant Protein

PROTP35070-1 Regular: 20ug
EUR 380.4
Description: Betacellulin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 80 amino acids and having a molecular mass of 9 kDa. ;Betacellulin Human Recombinant is purified by proprietary chromatographic techniques.

Betacellulin (bTC) Antibody (FITC)

20-abx274036
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody (FITC)

abx274036-05ml 0.5 ml
EUR 362.5

Betacellulin, murine (mouse)

RC238-23 5ug
EUR 125.26

BTC (Myc-DDK-tagged)-Human betacellulin (BTC)

RC202483 10 µg Ask for price

Betacellulin (bTC) Antibody (Biotin)

20-abx271925
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  • 100 ug
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  • 1 mg
  • 200 ug
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Betacellulin (bTC) Antibody (Biotin)

20-abx272658
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody (Biotin)

abx271925-1ml 1 ml
EUR 737.5

Betacellulin (bTC) Antibody (Biotin)

abx271925-200l 200 µl
EUR 337.5

Betacellulin (bTC) Antibody (Biotin)

abx272658-100l 100 µl
EUR 300

Betacellulin (bTC) Antibody (Biotin)

abx272658-1ml 1 ml Ask for price

Betacellulin (bTC) Antibody (Biotin)

abx272658-200l 200 µl
EUR 637.5

Rat Betacellulin ELISA Kit

IRTBTCKT each
EUR 702
Description: Rat Betacellulin ELISA Kit

Nori® Human Betacellulin ELISA Kit (2 plates)

GR106276-2 2 x 96-well
EUR 832

Rat Betacellulin antiserum (Rabbit)

PAAQ1 100 µl
EUR 358.8

Recombinant Betacellulin (bTC)

RPU40447-100ug 100ug
EUR 492.8

Recombinant Betacellulin (bTC)

RPU40447-1mg 1mg
EUR 2184

Recombinant Betacellulin (bTC)

RPU40447-50ug 50ug
EUR 396

Recombinant Betacellulin (bTC)

RPU40448-100ug 100ug
EUR 591.8

Recombinant Betacellulin (bTC)

RPU40448-1mg 1mg
EUR 2620.8

Recombinant Betacellulin (bTC)

RPU40448-50ug 50ug
EUR 475.2

Recombinant Betacellulin (bTC)

RPU57900-100ug 100ug
EUR 521.7

Recombinant Betacellulin (bTC)

RPU57900-1mg 1mg
EUR 2421.1

Recombinant Betacellulin (bTC)

RPU57900-50ug 50ug
EUR 426.8

Recombinant Betacellulin (bTC)

RPU56114-100ug 100ug
EUR 554.4

Recombinant Betacellulin (bTC)

RPU56114-1mg 1mg
EUR 2184

Recombinant Betacellulin (bTC)

RPU56114-50ug 50ug
EUR 336

Recombinant Betacellulin (bTC)

RPA112Hu01 10ug
EUR 160

Recombinant Betacellulin (bTC)

4-RPA112Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
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  • 5 mg
Description: Recombinant Human Betacellulin expressed in: E.coli

Recombinant Betacellulin (bTC)

RPA112Mu01 10ug
EUR 192

Recombinant Betacellulin (bTC)

4-RPA112Mu01
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  • 100 ug
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  • 200 ug
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  • 5 mg
Description: Recombinant Mouse Betacellulin expressed in: E.coli

Recombinant Betacellulin (bTC)

RPA112Ra01 10ug
EUR 140

Betacellulin (bTC) Polyclonal Antibody (Human), APC-Cy7

4-PAA112Hu01-APC-Cy7
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  • 100ul
  • 10ml
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  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with APC-Cy7.

Mouse Betacellulin ELISA KIT

E42EM-172 96T/48T Ask for price

Rat Betacellulin (bTC) Protein

20-abx652663
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cow Betacellulin (bTC) Protein

20-abx652665
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
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Mouse Betacellulin ELISA Kit

IMSBTCKT each
EUR 702
Description: Mouse Betacellulin ELISA Kit

Rat Betacellulin (bTC) Protein

abx652663-5mg 5 mg
EUR 337.5

Cow Betacellulin (bTC) Protein

abx652665-5mg 5 mg
EUR 5300

Human Betacellulin Flow Cytometry Assay - Group 10

HX87379 96 Tests
EUR 270

Human Betacellulin Recombinant Protein Lyophilized

IHUBTCRLY5UG each
EUR 341
Description: Human Betacellulin Recombinant Protein Lyophilized

Recombinant Mouse Betacellulin

cyt-131-1mg 1mg
EUR 2700

Recombinant Mouse Betacellulin

cyt-131-20g 20µg
EUR 145

Recombinant Mouse Betacellulin

cyt-131-5g 5µg
EUR 60

Betacellulin Mouse Recombinant

rAP-0362 Inquiry Ask for price

Betacellulin ELISA Kit (Human) : 96 Wells (OKAG00006)

OKAG00006 96 Wells
EUR 715.2
Description: Description of target: This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 8 pg/mL

Human Betacellulin Chemiluminescent Immunoassay Kit

IHUBTCKTC each
EUR 545
Description: Human Betacellulin Chemiluminescent Immunoassay Kit

Betacellulin (bTC) Polyclonal Antibody

CAU28583-100ul 100ul
EUR 182.4

Betacellulin (bTC) Polyclonal Antibody

CAU28583-200ul 200ul
EUR 228.5

Betacellulin (bTC) Polyclonal Antibody

CAU28584-100ul 100ul
EUR 212.2

Betacellulin (bTC) Polyclonal Antibody

CAU28584-200ul 200ul
EUR 265.4

Betacellulin (bTC) Polyclonal Antibody

CAU30301-100ul 100ul
EUR 229.4

Betacellulin (bTC) Polyclonal Antibody

CAU30301-200ul 200ul
EUR 287.3

Bovine Betacellulin antiserum (Rabbit)

PAAR1 100 µl
EUR 358.8

Recombinant Bovine Betacellulin

7-00226 5µg Ask for price

Recombinant Bovine Betacellulin

7-00227 20µg Ask for price

Recombinant Bovine Betacellulin

7-00228 1mg Ask for price

Recombinant Bovine Betacellulin

22060014-1 5 µg
EUR 146.42

Betacellulin, Murine Recombinant

7119-10 each
EUR 235.2

Betacellulin, Murine Recombinant

7119-50 each
EUR 810

Recombinant Murine Betacellulin

AP60204 100ug
EUR 896

Recombinant Murine BetaCellulin

MEOPP-0204 5ug Ask for price

Recombinant Bovine Betacellulin

cyt-406-1mg 1mg
EUR 3600

Recombinant Bovine Betacellulin

cyt-406-20g 20µg
EUR 145
The multi-targeted nanosystem confirmed significantly better uptake, increased PE38 expression, and subsequent cell loss of life in MDA-MB-231/HER2+ in comparison with MCF-10A. Nevertheless, the efficacy of our focused toxin gene remedy was decrease in MDA-MB-231/HER2+ spheroids in contrast with that within the monolayer tradition. the mixture of the cell floor, transcriptional, and translational concentrating on elevated the stringency of the remedy.

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