Basal cell carcinoma (BCC) is a major public well being concern, with greater than three million circumstances occurring every year in america, and with an growing incidence. The molecular foundation of BCC is advanced, involving an interaction of inherited genetic susceptibility, together with single nucleotide polymorphisms and genetic syndromes, and sporadic somatic mutations, typically induced by carcinogenic publicity to UV radiation.
This overview outlines the presently recognized germline and somatic mutations implicated within the pathogenesis of BCC, together with the important thing molecular pathways affected by these mutations, which drive oncogenesis. With advances in subsequent era sequencing and our understanding of the molecular genetics of BCC, established and rising focused therapeutics are providing new avenues for the non-surgical remedy of BCC. These brokers, together with Hedgehog pathway inhibitors, immune modulators, and histone deacetylase inhibitors, may even be mentioned.
XIAP gene remedy results on retinal ganglion cell construction and performance in a mouse mannequin of glaucoma
Glaucoma is a prevalent neurodegenerative illness that’s characterised by progressive visible discipline loss. It’s the main reason for irreversible blindness on the planet. The primary danger issue for glaucoma is elevated intraocular stress that leads to the injury and loss of life of retinal ganglion cells (RGCs) and their axons. The loss of life of RGCs has been proven to be apoptotic. We examined the speculation that blocking the activation of apoptosis could also be an efficient technique to forestall RGC loss of life and protect practical imaginative and prescient in glaucoma.
Within the magnetic microbead mouse mannequin of induced ocular hypertension, inhibition of RGC apoptosis was focused via viral-mediated ocular supply of the X-linked inhibitor of apoptosis (XIAP) gene, a potent caspase inhibitor. Sample electroretinograms revealed that XIAP remedy resulted in important safety of each somal and axonal RGC operate in glaucomatous eyes. Histology confirmed that the handled optic nerves confirmed preservation of axon counts and decreased glial cell infiltration. These outcomes present that XIAP is ready to present each practical and structural safety of RGCs within the microbead mannequin of glaucoma and supply vital proof-of-principle for XIAP’s efficacy as a neuroprotective remedy for glaucoma.
Major Mediastinal B-Cell Lymphoma: A 2021 Replace on Genetics, Prognosis, and Novel Therapeutics
Major mediastinal massive B-cell lymphoma (PMBCL) is an aggressive B-cell lymphoma arising from thymic B-cells having clinicopathologic options distinct from systemic diffuse massive B-cell lymphoma (DLBCL). PMBCL contains 2% to 4% of all non-Hodgkin lymphomas (NHL), 7% of DLBCL and seen predominantly in younger females with a median age of 35 years at analysis. The annual incidence of PMBCL is 0.Four per million with a 5-year survival charge exceeding 70% with enhancing supportive care and genetic characterization of the illness.
Pathogenesis entails dysregulation of Janus kinase-signal transducer and activator of transcription (JAK-STAT), nuclear factor-kB (NF-kB) pathways and amplification of the 9p24.1 area of chromosome 9. PMBCL sufferers have a protracted life expectancy necessitating the necessity for remedy approaches which can be based mostly on maximizing remedy with minimal long-term toxicity. Because of rarity and its recognition as a definite entity, therapeutic choices are guided by medical presentation, clinician and heart expertise, and evaluation of sufferers with PMBCL inside DLBCL registries.
Traditionally R-CHOP has been the standard first line remedy for PMBCL adopted by concerned web site radiotherapy (ISRT), nonetheless medical observe varies throughout facilities with rising consensus to keep away from upfront RT by using dose intense regimens (DA-EPOCH-R) in youthful and match sufferers. Prognosis of relapsed refractory PMBCL not responding to salvage chemotherapy is dismal, nonetheless there are a lot of rising choices together with Brentuximab Vedotin, immune examine level inhibitors and chimeric antigen receptor T-cell remedy. On this article, we concentrate on the pathogenesis, present and evolving therapies, and supply suggestions for optimum administration of sufferers with PMBCL.
PE38-based gene remedy of HER2-positive breast most cancers stem cells by way of VHH-redirected polyamidoamine dendrimers
Breast most cancers stem cells (BCSCs) resist standard therapies and trigger tumor recurrence. Nearly 25% of breast cancers overexpress human epidermal development issue receptor-2 (HER2). Right here we developed a novel multi-targeted nanosystem to particularly eradicate HER2+ BCSCs. Plasmids containing CXCR1 promoter, PE38 toxin, and 5’UTR of the fundamental fibroblast development factor-2 (bFGF 5’UTR) had been constructed. Polyamidoamine (PAMAM) dendrimers functionalized with anti-HER2 VHHs had been used for plasmid supply.
Stem cell proportion of MDA-MB-231, MDA-MB-231/HER2+ and MCF-10A had been evaluated by mammosphere formation assay. Hanging drop method was used to supply spheroids. The uptake, gene expression, and killing efficacy of the multi-targeted nanosystem had been evaluated in each monolayer and spheroid tradition. MDA-MB-231/HER2+ had increased capability to kind mammosphere in comparison with MCF-10A.
Our multi-targeted nanosystem effectively inhibited the mammosphere formation of MDA-MB-231 and MDA-MB-231/HER2+ cells, whereas it was unable to forestall the mammosphere formation of MCF-10A. Within the hanging drop tradition, MDA-MB-231/HER+ generated compact well-rounded spheroids, whereas MCF-10A did not kind compact mobile plenty.
anti- Betacellulin antibody |
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| FNab00883 | FN Test | 100µg | EUR 606.3 |
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Description: Antibody raised against Betacellulin |
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Human Betacellulin CLIA Kit |
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| MBS8425178-INQUIRE | MyBiosource | INQUIRE | Ask for price |
Recombinant Human Betacellulin |
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| 7-00223 | CHI Scientific | 5µg | Ask for price |
Recombinant Human Betacellulin |
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| 7-00224 | CHI Scientific | 20µg | Ask for price |
Recombinant Human Betacellulin |
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| 7-00225 | CHI Scientific | 1mg | Ask for price |
Human Betacellulin (Recombinant) |
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| 22060316-1 | Bio-WORLD | 5 µg | EUR 190.94 |
Recombinant Human Betacellulin |
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| cyt-330-1mg | ProSpec Tany | 1mg | EUR 2700 |
Recombinant Human Betacellulin |
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| cyt-330-20g | ProSpec Tany | 20µg | EUR 145 |
Recombinant Human Betacellulin |
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| cyt-330-5g | ProSpec Tany | 5µg | EUR 60 |
Recombinant Human Betacellulin |
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| AP60110 | SAB | 100ug | EUR 896 |
Recombinant Human BetaCellulin |
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| HEOPP-0212 | Cyagen | 5ug | Ask for price |
Recombinant Human Betacellulin |
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| MBS142207-0005mg | MyBiosource | 0.005mg | EUR 240 |
Recombinant Human Betacellulin |
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| MBS142207-002mg | MyBiosource | 0.02mg | EUR 310 |
Recombinant Human Betacellulin |
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| MBS142207-1mg | MyBiosource | 1mg | EUR 2880 |
Recombinant Human Betacellulin |
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| MBS142207-5x1mg | MyBiosource | 5x1mg | EUR 12630 |
Recombinant Human Betacellulin |
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| P1308-.005 | ApexBio | 5ug | EUR 108.8 |
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Description: Peptides & Proteins|Recombinant Proteins |
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Recombinant Human Betacellulin |
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| P1308-.1 | ApexBio | 100ug | EUR 900 |
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Description: Peptides & Proteins|Recombinant Proteins |
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Recombinant Human Betacellulin |
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| P1308-.5 | ApexBio | 500ug | EUR 2021.6 |
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Description: Peptides & Proteins|Recombinant Proteins |
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Human Betacellulin ELISA Kit |
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| IHUBTCKT | Innovative research | each | EUR 702 |
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Description: Human Betacellulin ELISA Kit |
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Human Betacellulin ELISA Kit |
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| GWB-SKR006 | GenWay Biotech | 96 Tests | Ask for price |
Human Betacellulin ELISA Kit |
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| MBS009811-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 6725 |
Human Betacellulin ELISA Kit |
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| MBS009811-48StripWells | MyBiosource | 48-Strip-Wells | EUR 550 |
Human Betacellulin ELISA Kit |
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| MBS009811-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 3420 |
Human Betacellulin ELISA Kit |
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| MBS009811-96StripWells | MyBiosource | 96-Strip-Wells | EUR 765 |
Human Betacellulin ELISA KIT |
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| E42EH-268 | EnoGene | 96T/48T | EUR 795 |
Human Betacellulin ELISA Kit |
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| MBS138113-1Kit | MyBiosource | 1Kit | EUR 755 |
Human Betacellulin ELISA Kit |
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| MBS138113-5x1Kit | MyBiosource | 5x1Kit | EUR 3455 |
Human Betacellulin ELISA Kit |
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| MBS763506-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3900 |
Human Betacellulin ELISA Kit |
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| MBS763506-48StripWells | MyBiosource | 48-Strip-Wells | EUR 340 |
Human Betacellulin ELISA Kit |
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| MBS763506-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2045 |
Human Betacellulin ELISA Kit |
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| MBS763506-96StripWells | MyBiosource | 96-Strip-Wells | EUR 455 |
Human Betacellulin ELISA Kit |
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| MBS824733-5x96Tests | MyBiosource | 5x96Tests | EUR 2880 |
Human Betacellulin ELISA Kit |
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| MBS824733-96Tests | MyBiosource | 96Tests | EUR 645 |
Human betacellulin ELISA Kit |
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| MBS727932-48StripWellsCompetitive | MyBiosource | 48-Strip-Wells-(Competitive) | EUR 485 |
Human betacellulin ELISA Kit |
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| MBS727932-48StripWellsSandwich | MyBiosource | 48-Strip-Wells-(Sandwich) | EUR 485 |
Human betacellulin ELISA Kit |
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| MBS727932-5x96StripWellsCompetitive | MyBiosource | 5x96-Strip-Wells-(Competitive) | EUR 3020 |
Human betacellulin ELISA Kit |
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| MBS727932-96StripWellsCompetitive | MyBiosource | 96-Strip-Wells-(Competitive) | EUR 690 |
Human betacellulin ELISA Kit |
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| MBS727932-96StripWellsSandwich | MyBiosource | 96-Strip-Wells-(Sandwich) | EUR 690 |
Betacellulin, Recombinant, Human |
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| MBS650210-0005mg | MyBiosource | 0.005mg | EUR 340 |
Betacellulin, Recombinant, Human |
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| MBS650210-002mg | MyBiosource | 0.02mg | EUR 490 |
Betacellulin, Recombinant, Human |
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| MBS650210-5x002mg | MyBiosource | 5x0.02mg | EUR 2055 |
Betacellulin Human Recombinant |
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| rAP-0363 | Angio Proteomie | Inquiry | Ask for price |
Betacellulin (Human) ELISA Kit |
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| EKA51822-5x96T | Biomatik Corporation | 5x96T | Ask for price |
Betacellulin (Human) ELISA Kit |
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| EKA51822-96T | Biomatik Corporation | 96T | EUR 446.9 |
Human Betacellulin (bTC) Protein |
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| abx065524-100g | Abbexa | 100 µg | EUR 537.5 |
Human Betacellulin (bTC) Protein |
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| 20-abx065524 | Abbexa |
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Human Betacellulin (bTC) Protein |
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| abx065524-10g | Abbexa | 10 µg | EUR 212.5 |
Human Betacellulin (bTC) Protein |
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| abx065524-50g | Abbexa | 50 µg | EUR 375 |
Human Betacellulin GENLISA ELISA |
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| KB1015 | Krishgen | 1 x 96 wells | EUR 198 |
Human Betacellulin (bTC) CLIA Kit |
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| abx196482-100l | Abbexa | 100 µl | Ask for price |
Human Betacellulin (bTC) CLIA Kit |
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| abx196482-50l | Abbexa | 50 µl | EUR 618.75 |
Human Betacellulin (bTC) CLIA Kit |
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| abx196482-96tests | Abbexa | 96 tests | EUR 990 |
Human Betacellulin (BTC) CLIA Kit |
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| 20-abx491043 | Abbexa |
|
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Human Betacellulin (BTC) ELISA Kit |
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| abx250182-96tests | Abbexa | 96 tests | EUR 493.75 |
Human Betacellulin (BTC) ELISA Kit |
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| abx570040-96tests | Abbexa | 96 tests | EUR 801.6 |
Human Betacellulin (bTC) ELISA Kit |
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| DL-bTC-Hu | DL Develop | 96T | EUR 402 |
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Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| DLR-bTC-Hu | DL Develop | 96T | EUR 422 |
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Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| DLR-bTC-Hu-48T | DL Develop | 48T | EUR 574.8 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| DLR-bTC-Hu-96T | DL Develop | 96T | EUR 745.2 |
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Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids. |
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Human Betacellulin, BTC ELISA Kit |
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| DEIA089 | Creative Diagnostics | 10 plates | EUR 2051.28 |
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Description: serum, plasma, other biological fluids |
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Human Betacellulin/BTC ELISA kit |
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| E22-HC017.48 | EnoGene | 48T | EUR 295 |
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Description: 15pg/ml |
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Human Betacellulin/BTC ELISA kit |
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| E22-HC017.96 | EnoGene | 96T | EUR 395 |
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Description: 15pg/ml |
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Human Betacellulin/BTC ELISA Kit |
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| EK5454 | SAB | 96 tests | EUR 599 |
Human Betacellulin (bTC) ELISA Kit |
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| EK12923 | SAB | 96Т | EUR 768 |
Human Betacellulin (bTC) ELISA Kit |
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| EKN43808-48T | Biomatik Corporation | 48T | EUR 341.04 |
Human Betacellulin (bTC) ELISA Kit |
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| EKN43808-5x96T | Biomatik Corporation | 5x96T | EUR 2314.2 |
Human Betacellulin (bTC) ELISA Kit |
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| EKN43808-96T | Biomatik Corporation | 96T | EUR 487.2 |
Human Betacellulin (bTC) ELISA Kit |
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| EKU02697-48T | Biomatik Corporation | 48T | EUR 500.5 |
Human Betacellulin (bTC) ELISA Kit |
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| EKU02697-5x96T | Biomatik Corporation | 5x96T | EUR 3396.25 |
Human Betacellulin (bTC) ELISA Kit |
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| EKU02697-96T | Biomatik Corporation | 96T | EUR 715 |
Human Betacellulin(BTC) ELISA Kit |
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| EIA07641h | Enlibio | each | EUR 430 |
Human Betacellulin/BTC ELISA Kit |
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| LF-EK50996 | Abfrontier | 1×96T | EUR 777.6 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 4910 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-24StripWells | MyBiosource | 24-Strip-Wells | EUR 340 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-48StripWells | MyBiosource | 48-Strip-Wells | EUR 500 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2675 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2020247-96StripWells | MyBiosource | 96-Strip-Wells | EUR 665 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS452002-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 4700 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS452002-48StripWells | MyBiosource | 48-Strip-Wells | EUR 410 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS452002-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2410 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS452002-96StripWells | MyBiosource | 96-Strip-Wells | EUR 545 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS457991-10x96Tests | MyBiosource | 10x96Tests | EUR 4890 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS457991-48Tests | MyBiosource | 48Tests | EUR 425 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS457991-5x96Tests | MyBiosource | 5x96Tests | EUR 2495 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS457991-96Tests | MyBiosource | 96Tests | EUR 560 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 2830 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-24StripWells | MyBiosource | 24-Strip-Wells | EUR 240 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-48StripWells | MyBiosource | 48-Strip-Wells | EUR 315 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1480 |
Human Betacellulin (bTC) ELISA Kit |
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| MBS2701248-96StripWells | MyBiosource | 96-Strip-Wells | EUR 385 |
Human Betacellulin (BTC) ELISA Kit |
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| MBS2610656-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3040 |
Human Betacellulin (BTC) ELISA Kit |
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| MBS2610656-48StripWells | MyBiosource | 48-Strip-Wells | EUR 285 |
Human Betacellulin (BTC) ELISA Kit |
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| MBS2610656-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1670 |
Human Betacellulin (BTC) ELISA Kit |
|||
| MBS2610656-96StripWells | MyBiosource | 96-Strip-Wells | EUR 405 |
Human Betacellulin/BTC ELISA Kit |
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| MBS8579158-48Tests | MyBiosource | 48Tests | EUR 390 |
Human Betacellulin/BTC ELISA Kit |
|||
| MBS8579158-5x96Tests | MyBiosource | 5x96Tests | EUR 2275 |
Human Betacellulin/BTC ELISA Kit |
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| MBS8579158-96Tests | MyBiosource | 96Tests | EUR 495 |
Human Betacellulin (bTC) ELISA Kit |
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| RDR-bTC-Hu-48T | Reddot Biotech | 48T | EUR 454 |
|
Description: sandwich |
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Human Betacellulin (bTC) ELISA Kit |
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| RDR-bTC-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 600 |
Human Betacellulin (bTC) ELISA Kit |
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| RDR-bTC-Hu-96T | Reddot Biotech | 96T | EUR 648 |
|
Description: sandwich |
|||
Human Betacellulin (bTC) ELISA Kit |
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| RDR-bTC-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 830.4 |
Human Betacellulin (bTC) ELISA Kit |
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| SEA112Hu-10x96wellstestplate | Cloud-Clone | 10x96-wells test plate | EUR 5128.02 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
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Human Betacellulin (bTC) ELISA Kit |
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| SEA112Hu-1x48wellstestplate | Cloud-Clone | 1x48-wells test plate | EUR 527.48 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
|||
Human Betacellulin (bTC) ELISA Kit |
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| SEA112Hu-1x96wellstestplate | Cloud-Clone | 1x96-wells test plate | EUR 702.12 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
|||
Human Betacellulin (bTC) ELISA Kit |
|||
| SEA112Hu-5x96wellstestplate | Cloud-Clone | 5x96-wells test plate | EUR 2799.54 |
|
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
|||
Human Betacellulin (bTC) ELISA Kit |
|||
| 4-SEA112Hu | Cloud-Clone |
|
|
|
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species. |
|||
Human Betacellulin (bTC) ELISA Kit |
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| RD-bTC-Hu-48T | Reddot Biotech | 48T | EUR 432 |
|
Description: sandwich |
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Human Betacellulin (bTC) ELISA Kit |
|||
| RD-bTC-Hu-48Tests | Reddot Biotech | 48 Tests | EUR 573.6 |
Human Betacellulin (bTC) ELISA Kit |
|||
| RD-bTC-Hu-96T | Reddot Biotech | 96T | EUR 617 |
|
Description: sandwich |
|||
Human Betacellulin (bTC) ELISA Kit |
|||
| RD-bTC-Hu-96Tests | Reddot Biotech | 96 Tests | EUR 794.4 |
Human Betacellulin(BTC)ELISA Kit |
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| YLA3880HU-48T | Shanghai YL Biotech | 48T | Ask for price |
Human Betacellulin(BTC)ELISA Kit |
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| YLA3880HU-96T | Shanghai YL Biotech | 96T | Ask for price |
Recombinant Human Betacellulin, HEK |
|||
| cyt-1188-10g | ProSpec Tany | 10µg | EUR 145 |
Recombinant Human Betacellulin, HEK |
|||
| cyt-1188-1mg | ProSpec Tany | 1mg | EUR 5200 |
Recombinant Human Betacellulin, HEK |
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| cyt-1188-2g | ProSpec Tany | 2µg | EUR 60 |
Recombinant Human Betacellulin, HEK |
|||
| MBS147328-0002mg | MyBiosource | 0.002mg | EUR 240 |
Recombinant Human Betacellulin, HEK |
|||
| MBS147328-001mg | MyBiosource | 0.01mg | EUR 310 |
Recombinant Human Betacellulin, HEK |
|||
| MBS147328-1mg | MyBiosource | 1mg | EUR 5345 |
Recombinant Human Betacellulin, HEK |
|||
| MBS147328-5x1mg | MyBiosource | 5x1mg | EUR 23725 |
Human BTC -Betacellulin- CLIA Kit |
|||
| E-CL-H0444-24Tests | Elabscience Biotech | 24 Tests | EUR 180 |
|
Description: Sandwich |
|||
Human BTC -Betacellulin- CLIA Kit |
|||
| E-CL-H0444-48Tests | Elabscience Biotech | 48 Tests | EUR 546 |
|
Description: Sandwich |
|||
Human BTC -Betacellulin- CLIA Kit |
|||
| E-CL-H0444-96Tests | Elabscience Biotech | 96 Tests | EUR 682 |
|
Description: Sandwich |
|||
Human BTC -Betacellulin- CLIA Kit |
|||
| E-CL-H0444-96Tests10 | Elabscience Biotech | 96 Tests *10 | EUR 6820 |
|
Description: Sandwich |
|||
Human BTC -Betacellulin- CLIA Kit |
|||
| E-CL-H0444-96Tests5 | Elabscience Biotech | 96 Tests *5 | EUR 3410 |
|
Description: Sandwich |
|||
Human bTC (Betacellulin) CLIA Kit |
|||
| MBS2531178-5x96Tests | MyBiosource | 5x96Tests | EUR 2565 |
Human bTC (Betacellulin) CLIA Kit |
|||
| MBS2531178-96Tests | MyBiosource | 96Tests | EUR 560 |
Anti-BTC/Betacellulin Antibody |
|||
| MBS2400715-005mg | MyBiosource | 0.05mg | EUR 595 |
Anti-BTC/Betacellulin Antibody |
|||
| MBS2400715-5x005mg | MyBiosource | 5x0.05mg | EUR 2500 |
Human Betacellulin Protein, Fc Tag |
|||
| BEN-H525x | ACROBIOSYSTEMS | 1mg | EUR 381.5 |
|
Description: Human Betacellulin, Fc Tag (BEN-H525x) is expressed from human 293 cells (HEK293). It contains AA Asp 32 - Tyr 111 (Accession # AAH11618). |
|||
Human BTC (Betacellulin) ELISA Kit |
|||
| EKE60392-5x96T | Biomatik Corporation | 5x96T | EUR 3124.08 |
Human BTC (Betacellulin) ELISA Kit |
|||
| EKE60392-96T | Biomatik Corporation | 96T | EUR 657.7 |
Human BTC(Betacellulin) ELISA Kit |
|||
| EH0044 | FN Test | 96T | EUR 628.92 |
|
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml |
|||
Human bTC (Betacellulin) ELISA Kit |
|||
| MBS2505147-10x96Tests | MyBiosource | 10x96Tests | EUR 4060 |
Human bTC (Betacellulin) ELISA Kit |
|||
| MBS2505147-24Tests | MyBiosource | 24Tests | EUR 265 |
Human bTC (Betacellulin) ELISA Kit |
|||
| MBS2505147-48Tests | MyBiosource | 48Tests | EUR 450 |
Human bTC (Betacellulin) ELISA Kit |
|||
| MBS2505147-5x96Tests | MyBiosource | 5x96Tests | EUR 2265 |
Human bTC (Betacellulin) ELISA Kit |
|||
| MBS2505147-96Tests | MyBiosource | 96Tests | EUR 535 |
Human bTC (Betacellulin) ELISA Kit |
|||
| MBS8800404-10x96StripWells | MyBiosource | 10x96-Strip-Wells | EUR 3130 |
Human bTC (Betacellulin) ELISA Kit |
|||
| MBS8800404-48StripWells | MyBiosource | 48-Strip-Wells | EUR 350 |
Human bTC (Betacellulin) ELISA Kit |
|||
| MBS8800404-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 1710 |
Human bTC (Betacellulin) ELISA Kit |
|||
| MBS8800404-96StripWells | MyBiosource | 96-Strip-Wells | EUR 445 |
Human BTC(Betacellulin) ELISA Kit |
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| RE2928H-48wells | Reed Biotech | 48 wells | EUR 116.55 |
Human BTC(Betacellulin) ELISA Kit |
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| RE2928H-48wellsplate | Reed Biotech | 48 wells plate | EUR 126 |
Human BTC(Betacellulin) ELISA Kit |
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| RE2928H-96wells | Reed Biotech | 96 wells | EUR 161.55 |
Human BTC(Betacellulin) ELISA Kit |
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| RE2928H-96wellsplate | Reed Biotech | 96 wells plate | EUR 180 |
Anti-Mouse Betacellulin Antibody |
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| 103-M308 | ReliaTech | 100 µg | EUR 399 |
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Description: Betacellulin (BTC) is a new member of the EGF family of cytokines that is comprised of at least ten proteins including EGF, TGFα, amphiregulin, HB-EGF, and the various heregulins. All of these cytokines are synthesized as transmembrane precursors and are characterized by the presence of one or more EGF structural units in their extracellular domain. The soluble forms of these cytokines are released by proteolytic cleavage. BTC, a heparin binding protein, was originally isolated from the conditioned media of mouse pancreatic beta tumor cells as a 32 kDa glycoprotein composed of 80 amino acid residues. The cDNA encoding human BTC was cloned from a human breast adenocarcinoma cell line (MCF7) cDNA library. Human and mouse cDNAs encode BTC precursor proteins of 178 and 177 amino acid residues, respectively. At the amino acid sequence level, human BTC precursor protein exhibits 79% identity with that of the mouse BTC precursor. In a mouse cell line transfected with human BTC cDNA, three forms of soluble human BTC have been detected: the glycosylated, intact BTC composed of 80 amino acid residues, a truncated molecule lacking 12 amino acid residues from the amino terminus, and a second truncated molecule lacking 30 amino acid residues from the amino-terminus. The biological activities of these BTC forms were shown to be identical. BTC can bind to the EGF receptor and is a potent mitogen for Balb/c 3T3 fibroblasts, retinal pigment epithelial cells and vascular smooth muscle cells. |
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Recombinant Human Betacellulin (rHuBTC) |
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| JOT-PR1006 | Jotbody | 5µg | EUR 205 |
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Description: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg. |
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Recombinant Human Betacellulin (rHuBTC) |
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| PR1006 | Bioworld Biotech | 5µg | EUR 158 |
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Description: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg. |
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BTC (untagged)-Human betacellulin (BTC) |
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| SC309035 | Origene Technologies GmbH | 10 µg | Ask for price |
Human Betacellulin Recombinant Protein |
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| 100-332 | ReliaTech | 20 µg | EUR 196.35 |
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Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein. |
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Human Betacellulin Recombinant Protein |
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| 100-332S | ReliaTech | 5 µg | EUR 92.4 |
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Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein. |
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Recombinant Human Betacellulin protein |
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| CD02256-5ug | Jiaxing Korain Biotech Ltd (BT Labs) | 5ug | EUR 176 |
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Description: Betacellulin (BTC) is a member of the EGF family of cytokines that also includes EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. It is expressed in most tissues including kidney, uterus, liver and pancreas. BTC also presents in body fluids, including serum, milk, and colostrum. At the amino acid sequence level, human mature BTC protein exhibits 80 % identity with mouse BTC protein. The protein binds to EGFR, ERBB4 and other EGF receptor family members and acts as a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. |
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Human Betacellulin Recombinant Protein |
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| PROTP35070 | BosterBio | Regular: 10ug | EUR 265 |
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Description: Human Betacellulin Recombinant Protein expressed in E. coli with His-tag. Sequence domain: 32-111aa. Application(s): SDS-PAGE. Endotoxin: < 1 EU per 1ug of protein (determined by LAL method). |
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Recombinant Human Betacellulin Protein |
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| PROTP35070-2 | BosterBio | 20ug | EUR 380.4 |
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Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein. |
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Betacellulin (bTC) Polyclonal Antibody (Human) |
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| 4-PAA112Hu01 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC) |
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Betacellulin (Human) LumiAb ELISA Kit |
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| MBS9510760-1x96Wells | MyBiosource | 1x96Wells | EUR 520 |
Betacellulin (Human) LumiAb ELISA Kit |
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| MBS9510760-5x96Wells | MyBiosource | 5x96Wells | EUR 2395 |
Betacellulin (HEK293-expressed)， Human |
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| HY-P7328 | MedChemExpress | 10ug | EUR 280.8 |
Human Betacellulin (bTC) Protein (Active) |
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| 20-abx655563 | Abbexa |
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Human Betacellulin (bTC) Protein (Active) |
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| abx655563-50g | Abbexa | 50 µg | EUR 3712.5 |
Nori® Human Betacellulin ELISA Kit |
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| GR106276 | Genorise Scientific | 96-well | EUR 461 |
Recombinant Human Betacellulin, His Tag |
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| cyt-077-10g | ProSpec Tany | 10µg | EUR 145 |
Recombinant Human Betacellulin, His Tag |
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| cyt-077-1mg | ProSpec Tany | 1mg | EUR 5200 |
Recombinant Human Betacellulin, His Tag |
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| cyt-077-2g | ProSpec Tany | 2µg | EUR 60 |
Recombinant Human Betacellulin, His Tag |
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| MBS144451-0002mg | MyBiosource | 0.002mg | EUR 240 |
Recombinant Human Betacellulin, His Tag |
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| MBS144451-001mg | MyBiosource | 0.01mg | EUR 310 |
Recombinant Human Betacellulin, His Tag |
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| MBS144451-1mg | MyBiosource | 1mg | EUR 5345 |
Recombinant Human Betacellulin, His Tag |
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| MBS144451-5x1mg | MyBiosource | 5x1mg | EUR 23725 |
CLIA kit for Human BTC (Betacellulin) |
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| E-CL-H0444 | Elabscience Biotech | 1 plate of 96 wells | EUR 700.8 |
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Description: A sandwich CLIA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant |
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Betacellulin antibody |
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| 70R-BR013 | Fitzgerald | 50 ug | EUR 312 |
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Description: Affinity purified Rabbit polyclonal Betacellulin antibody |
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Betacellulin antibody |
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| MBS535912-005mg | MyBiosource | 0.05mg | EUR 465 |
Betacellulin antibody |
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| MBS535912-5x005mg | MyBiosource | 5x0.05mg | EUR 1945 |
Betacellulin (Human) Sandwich ELISA Kit |
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| OK-0105 | Assay Biotech | 1Kit | EUR 217 |
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Description: Betacellulin (Human) Colorimetric Sandwich ELISA Kit |
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Betacellulin (Human) OmniKine ELISA Kit |
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| MBS9501832-1x96Wells | MyBiosource | 1x96Wells | EUR 500 |
Betacellulin (Human) OmniKine ELISA Kit |
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| MBS9501832-5x96Wells | MyBiosource | 5x96Wells | EUR 2300 |
ELISA kit for Human BTC (Betacellulin) |
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| E-EL-H0570 | Elabscience Biotech | 1 plate of 96 wells | EUR 640.8 |
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Description: A sandwich ELISA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant |
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ELISA kit for Human bTC (Betacellulin) |
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| ELK1403 | ELK Biotech | 1 plate of 96 wells | EUR 518.4 |
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Description: A sandwich ELISA kit for detection of Betacellulin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. |
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Betacellulin Human Recombinant, His Tag |
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| rAP-0361 | Angio Proteomie | Inquiry | Ask for price |
BTC (GFP-tagged) - Human betacellulin (BTC) |
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| RG202483 | Origene Technologies GmbH | 10 µg | Ask for price |
HumanbTC(Betacellulin)ELISAKit |
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| ELK1403-48T | ELK Biotech | 48T | EUR 160 |
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Description: Sandwich |
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HumanbTC(Betacellulin)ELISAKit |
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| ELK1403-96T | ELK Biotech | 96T | EUR 229 |
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Description: Sandwich |
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Sheep Polyclonal anti-human Betacellulin (BTC) |
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| hAP-5047 | Angio Proteomie | 50ug | EUR 400 |
Sheep Polyclonal anti-Human Betacellulin (BTC) |
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| hAP-5649 | Angio Proteomie | 50ug | EUR 400 |
Betacellulin (bTC) Polyclonal Antibody (Human), PE |
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| 4-PAA112Hu01-PE | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with PE. |
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Betacellulin (BTC) |
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| THP-0274 | Creative BioMart | 1 vial | EUR 3198.4 |
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Description: Protein |
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EasyPro Human Betacellulin(BTC)ELISA Kit |
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| FY-EH2928S | Feiyuebio | each | EUR 520 |
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Description: 9.38 pg/mL |
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Recombinant human Betacellulin/BTC Protein |
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| MBS201329-001mg | MyBiosource | 0.01mg | EUR 255 |
Recombinant human Betacellulin/BTC Protein |
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| MBS201329-002mg | MyBiosource | 0.02mg | EUR 345 |
Recombinant human Betacellulin/BTC Protein |
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| MBS201329-005mg | MyBiosource | 0.05mg | EUR 415 |
Recombinant human Betacellulin/BTC Protein |
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| MBS201329-01mg | MyBiosource | 0.1mg | EUR 610 |
Recombinant human Betacellulin/BTC Protein |
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| MBS201329-025mg | MyBiosource | 0.25mg | EUR 985 |
Recombinant Human Betacellulin/BTC Protein |
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| RP01700 | Abclonal | 10μg | EUR 258.6 |
Betacellulin (bTC) Polyclonal Antibody (Human), APC |
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| 4-PAA112Hu01-APC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with APC. |
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Betacellulin (bTC) Polyclonal Antibody (Human), Cy3 |
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| 4-PAA112Hu01-Cy3 | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with Cy3. |
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Betacellulin (bTC) Polyclonal Antibody (Human), HRP |
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| 4-PAA112Hu01-HRP | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with HRP. |
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Human Betacellulin/BTC PicoKine ELISA Kit |
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| MBS177180-5x96StripWells | MyBiosource | 5x96-Strip-Wells | EUR 2755 |
Human Betacellulin/BTC PicoKine ELISA Kit |
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| MBS177180-96StripWells | MyBiosource | 96-Strip-Wells | EUR 600 |
Betacellulin (bTC) Polyclonal Antibody (Human), FITC |
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| 4-PAA112Hu01-FITC | Cloud-Clone |
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Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with FITC. |
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Betacellulin, Mouse |
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| HY-P7329 | MedChemExpress | 50ug | EUR 734.4 |
The multi-targeted nanosystem confirmed significantly better uptake, increased PE38 expression, and subsequent cell loss of life in MDA-MB-231/HER2+ in comparison with MCF-10A. Nevertheless, the efficacy of our focused toxin gene remedy was decrease in MDA-MB-231/HER2+ spheroids in contrast with that within the monolayer tradition. the mixture of the cell floor, transcriptional, and translational concentrating on elevated the stringency of the remedy.