Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics

Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics

Basal cell carcinoma (BCC) is a major public well being concern, with greater than three million circumstances occurring every year in america, and with an growing incidence. The molecular foundation of BCC is advanced, involving an interaction of inherited genetic susceptibility, together with single nucleotide polymorphisms and genetic syndromes, and sporadic somatic mutations, typically induced by carcinogenic publicity to UV radiation.
This overview outlines the presently recognized germline and somatic mutations implicated within the pathogenesis of BCC, together with the important thing molecular pathways affected by these mutations, which drive oncogenesis. With advances in subsequent era sequencing and our understanding of the molecular genetics of BCC, established and rising focused therapeutics are providing new avenues for the non-surgical remedy of BCC. These brokers, together with Hedgehog pathway inhibitors, immune modulators, and histone deacetylase inhibitors, may even be mentioned.

XIAP gene remedy results on retinal ganglion cell construction and performance in a mouse mannequin of glaucoma

Glaucoma is a prevalent neurodegenerative illness that’s characterised by progressive visible discipline loss. It’s the main reason for irreversible blindness on the planet. The primary danger issue for glaucoma is elevated intraocular stress that leads to the injury and loss of life of retinal ganglion cells (RGCs) and their axons. The loss of life of RGCs has been proven to be apoptotic. We examined the speculation that blocking the activation of apoptosis could also be an efficient technique to forestall RGC loss of life and protect practical imaginative and prescient in glaucoma.
Within the magnetic microbead mouse mannequin of induced ocular hypertension, inhibition of RGC apoptosis was focused via viral-mediated ocular supply of the X-linked inhibitor of apoptosis (XIAP) gene, a potent caspase inhibitor. Sample electroretinograms revealed that XIAP remedy resulted in important safety of each somal and axonal RGC operate in glaucomatous eyes. Histology confirmed that the handled optic nerves confirmed preservation of axon counts and decreased glial cell infiltration. These outcomes present that XIAP is ready to present each practical and structural safety of RGCs within the microbead mannequin of glaucoma and supply vital proof-of-principle for XIAP’s efficacy as a neuroprotective remedy for glaucoma.

Major Mediastinal B-Cell Lymphoma: A 2021 Replace on Genetics, Prognosis, and Novel Therapeutics

Major mediastinal massive B-cell lymphoma (PMBCL) is an aggressive B-cell lymphoma arising from thymic B-cells having clinicopathologic options distinct from systemic diffuse massive B-cell lymphoma (DLBCL). PMBCL contains 2% to 4% of all non-Hodgkin lymphomas (NHL), 7% of DLBCL and seen predominantly in younger females with a median age of 35 years at analysis. The annual incidence of PMBCL is 0.Four per million with a 5-year survival charge exceeding 70% with enhancing supportive care and genetic characterization of the illness.
 Review of the Molecular Genetics of Basal Cell Carcinoma; Inherited Susceptibility, Somatic Mutations, and Targeted Therapeutics
Pathogenesis entails dysregulation of Janus kinase-signal transducer and activator of transcription (JAK-STAT), nuclear factor-kB (NF-kB) pathways and amplification of the 9p24.1 area of chromosome 9. PMBCL sufferers have a protracted life expectancy necessitating the necessity for remedy approaches which can be based mostly on maximizing remedy with minimal long-term toxicity. Because of rarity and its recognition as a definite entity, therapeutic choices are guided by medical presentation, clinician and heart expertise, and evaluation of sufferers with PMBCL inside DLBCL registries.
Traditionally R-CHOP has been the standard first line remedy for PMBCL adopted by concerned web site radiotherapy (ISRT), nonetheless medical observe varies throughout facilities with rising consensus to keep away from upfront RT by using dose intense regimens (DA-EPOCH-R) in youthful and match sufferers. Prognosis of relapsed refractory PMBCL not responding to salvage chemotherapy is dismal, nonetheless there are a lot of rising choices together with Brentuximab Vedotin, immune examine level inhibitors and chimeric antigen receptor T-cell remedy. On this article, we concentrate on the pathogenesis, present and evolving therapies, and supply suggestions for optimum administration of sufferers with PMBCL.

PE38-based gene remedy of HER2-positive breast most cancers stem cells by way of VHH-redirected polyamidoamine dendrimers

Breast most cancers stem cells (BCSCs) resist standard therapies and trigger tumor recurrence. Nearly 25% of breast cancers overexpress human epidermal development issue receptor-2 (HER2). Right here we developed a novel multi-targeted nanosystem to particularly eradicate HER2+ BCSCs. Plasmids containing CXCR1 promoter, PE38 toxin, and 5’UTR of the fundamental fibroblast development factor-2 (bFGF 5’UTR) had been constructed. Polyamidoamine (PAMAM) dendrimers functionalized with anti-HER2 VHHs had been used for plasmid supply.
Stem cell proportion of MDA-MB-231, MDA-MB-231/HER2+ and MCF-10A had been evaluated by mammosphere formation assay. Hanging drop method was used to supply spheroids. The uptake, gene expression, and killing efficacy of the multi-targeted nanosystem had been evaluated in each monolayer and spheroid tradition. MDA-MB-231/HER2+ had increased capability to kind mammosphere in comparison with MCF-10A.
Our multi-targeted nanosystem effectively inhibited the mammosphere formation of MDA-MB-231 and MDA-MB-231/HER2+ cells, whereas it was unable to forestall the mammosphere formation of MCF-10A. Within the hanging drop tradition, MDA-MB-231/HER+ generated compact well-rounded spheroids, whereas MCF-10A did not kind compact mobile plenty.

anti- Betacellulin antibody

FNab00883 100µg
EUR 606.3
Description: Antibody raised against Betacellulin

Human Betacellulin CLIA Kit

MBS8425178-INQUIRE INQUIRE Ask for price

Recombinant Human Betacellulin

7-00223 5µg Ask for price

Recombinant Human Betacellulin

7-00224 20µg Ask for price

Recombinant Human Betacellulin

7-00225 1mg Ask for price

Human Betacellulin (Recombinant)

22060316-1 5 µg
EUR 146.42

Recombinant Human Betacellulin

AP60110 100ug
EUR 896

Recombinant Human BetaCellulin

HEOPP-0212 5ug Ask for price

Recombinant Human Betacellulin

cyt-330-1mg 1mg
EUR 2700

Recombinant Human Betacellulin

cyt-330-20g 20µg
EUR 145

Recombinant Human Betacellulin

cyt-330-5g 5µg
EUR 60

Recombinant Human Betacellulin

MBS142207-0005mg 0.005mg
EUR 240

Recombinant Human Betacellulin

MBS142207-002mg 0.02mg
EUR 310

Recombinant Human Betacellulin

MBS142207-1mg 1mg
EUR 2880

Recombinant Human Betacellulin

MBS142207-5x1mg 5x1mg
EUR 12630

Recombinant Human Betacellulin

P1308-.005 5ug
EUR 108.8
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Betacellulin

P1308-.1 100ug
EUR 900
Description: Peptides & Proteins|Recombinant Proteins

Recombinant Human Betacellulin

P1308-.5 500ug
EUR 2021.6
Description: Peptides & Proteins|Recombinant Proteins

Human Betacellulin ELISA KIT

E42EH-268 96T/48T Ask for price

Human Betacellulin ELISA Kit

MBS009811-10x96StripWells 10x96-Strip-Wells
EUR 6725

Human Betacellulin ELISA Kit

MBS009811-48StripWells 48-Strip-Wells
EUR 550

Human Betacellulin ELISA Kit

MBS009811-5x96StripWells 5x96-Strip-Wells
EUR 3420

Human Betacellulin ELISA Kit

MBS009811-96StripWells 96-Strip-Wells
EUR 765

Human Betacellulin ELISA Kit

IHUBTCKT each
EUR 702
Description: Human Betacellulin ELISA Kit

Human Betacellulin ELISA Kit

GWB-SKR006 96 Tests Ask for price

Human betacellulin ELISA Kit

MBS727932-48StripWellsCompetitive 48-Strip-Wells-(Competitive)
EUR 485

Human betacellulin ELISA Kit

MBS727932-48StripWellsSandwich 48-Strip-Wells-(Sandwich)
EUR 485

Human betacellulin ELISA Kit

MBS727932-5x96StripWellsCompetitive 5x96-Strip-Wells-(Competitive)
EUR 3020

Human betacellulin ELISA Kit

MBS727932-96StripWellsCompetitive 96-Strip-Wells-(Competitive)
EUR 690

Human betacellulin ELISA Kit

MBS727932-96StripWellsSandwich 96-Strip-Wells-(Sandwich)
EUR 690

Human Betacellulin ELISA Kit

MBS763506-10x96StripWells 10x96-Strip-Wells
EUR 3900

Human Betacellulin ELISA Kit

MBS763506-48StripWells 48-Strip-Wells
EUR 340

Human Betacellulin ELISA Kit

MBS763506-5x96StripWells 5x96-Strip-Wells
EUR 2045

Human Betacellulin ELISA Kit

MBS763506-96StripWells 96-Strip-Wells
EUR 455

Human Betacellulin ELISA Kit

MBS824733-5x96Tests 5x96Tests
EUR 2880

Human Betacellulin ELISA Kit

MBS824733-96Tests 96Tests
EUR 645

Human Betacellulin ELISA Kit

MBS138113-1Kit 1Kit
EUR 755

Human Betacellulin ELISA Kit

MBS138113-5x1Kit 5x1Kit
EUR 3455

Betacellulin Human Recombinant

rAP-0363 Inquiry Ask for price

Betacellulin, Recombinant, Human

MBS650210-0005mg 0.005mg
EUR 340

Betacellulin, Recombinant, Human

MBS650210-002mg 0.02mg
EUR 490

Betacellulin, Recombinant, Human

MBS650210-5x002mg 5x0.02mg
EUR 2055

Betacellulin (Human) ELISA Kit

EKA51822-5x96T 5x96T Ask for price

Betacellulin (Human) ELISA Kit

EKA51822-96T 96T
EUR 446.9

Human Betacellulin (bTC) Protein

20-abx065524
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Betacellulin (bTC) Protein

abx065524-100g 100 µg
EUR 537.5

Human Betacellulin (bTC) Protein

abx065524-10g 10 µg
EUR 212.5

Human Betacellulin (bTC) Protein

abx065524-50g 50 µg
EUR 375

Human Betacellulin GENLISA ELISA

KB1015 1 x 96 wells
EUR 198

Human Betacellulin (bTC) CLIA Kit

abx196482-96tests 96 tests
EUR 990

Human Betacellulin (BTC) CLIA Kit

20-abx491043
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  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Betacellulin (bTC) CLIA Kit

abx196482-100l 100 µl Ask for price

Human Betacellulin (bTC) CLIA Kit

abx196482-50l 50 µl
EUR 618.75

Human Betacellulin (BTC) ELISA Kit

abx250182-96tests 96 tests
EUR 801.6

Human Betacellulin (BTC) ELISA Kit

abx570040-96tests 96 tests
EUR 801.6

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu 96T
EUR 422
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin (bTC) ELISA Kit

EKN43808-48T 48T
EUR 341.04

Human Betacellulin (bTC) ELISA Kit

EKN43808-5x96T 5x96T
EUR 2314.2

Human Betacellulin (bTC) ELISA Kit

EKN43808-96T 96T
EUR 487.2

Human Betacellulin (bTC) ELISA Kit

EKU02697-48T 48T
EUR 500.5

Human Betacellulin (bTC) ELISA Kit

EKU02697-5x96T 5x96T
EUR 3396.25

Human Betacellulin (bTC) ELISA Kit

EKU02697-96T 96T
EUR 715

Human Betacellulin (bTC) ELISA Kit

DL-bTC-Hu 96T
EUR 402
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin, BTC ELISA Kit

DEIA089 10 plates
EUR 3126
Description: This assay is a sandwich Enzyme Linked-Immuno-Sorbent Assay (ELISA). It is developed for quantitative measurement of human BTC in serum, plasma and other biological fluids.

Human Betacellulin/BTC ELISA kit

E22-HC017.48 48T
EUR 295

Human Betacellulin/BTC ELISA kit

E22-HC017.96 96T
EUR 395

Human Betacellulin (bTC) ELISA Kit

EK12923 96Т
EUR 768

Human Betacellulin/BTC ELISA Kit

EK5454 96 tests
EUR 599

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

4-SEA112Hu
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  • Ask for price
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Betacellulin(BTC)ELISA Kit

YLA3880HU-48T 48T Ask for price

Human Betacellulin(BTC)ELISA Kit

YLA3880HU-96T 96T Ask for price

Human Betacellulin/BTC ELISA Kit

LF-EK50996 1×96T
EUR 777.6

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-48T 48T
EUR 411.8
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-48Tests 48 Tests
EUR 573.6

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-96T 96T
EUR 588.3
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-96Tests 96 Tests
EUR 794.4

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-48T 48T
EUR 432.39
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-48Tests 48 Tests
EUR 600

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-96T 96T
EUR 617.72
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-96Tests 96 Tests
EUR 830.4

Human Betacellulin/BTC ELISA Kit

MBS8579158-48Tests 48Tests
EUR 390

Human Betacellulin/BTC ELISA Kit

MBS8579158-5x96Tests 5x96Tests
EUR 2275

Human Betacellulin/BTC ELISA Kit

MBS8579158-96Tests 96Tests
EUR 495

Human Betacellulin (bTC) ELISA Kit

MBS2020247-10x96StripWells 10x96-Strip-Wells
EUR 4910

Human Betacellulin (bTC) ELISA Kit

MBS2020247-24StripWells 24-Strip-Wells
EUR 340

Human Betacellulin (bTC) ELISA Kit

MBS2020247-48StripWells 48-Strip-Wells
EUR 500

Human Betacellulin (bTC) ELISA Kit

MBS2020247-5x96StripWells 5x96-Strip-Wells
EUR 2675

Human Betacellulin (bTC) ELISA Kit

MBS2020247-96StripWells 96-Strip-Wells
EUR 665

Human Betacellulin (bTC) ELISA Kit

MBS452002-10x96StripWells 10x96-Strip-Wells
EUR 4700

Human Betacellulin (bTC) ELISA Kit

MBS452002-48StripWells 48-Strip-Wells
EUR 410

Human Betacellulin (bTC) ELISA Kit

MBS452002-5x96StripWells 5x96-Strip-Wells
EUR 2410

Human Betacellulin (bTC) ELISA Kit

MBS452002-96StripWells 96-Strip-Wells
EUR 545

Human Betacellulin (bTC) ELISA Kit

MBS2701248-10x96StripWells 10x96-Strip-Wells
EUR 2830

Human Betacellulin (bTC) ELISA Kit

MBS2701248-24StripWells 24-Strip-Wells
EUR 240

Human Betacellulin (bTC) ELISA Kit

MBS2701248-48StripWells 48-Strip-Wells
EUR 315

Human Betacellulin (bTC) ELISA Kit

MBS2701248-5x96StripWells 5x96-Strip-Wells
EUR 1480

Human Betacellulin (bTC) ELISA Kit

MBS2701248-96StripWells 96-Strip-Wells
EUR 385

Human Betacellulin (BTC) ELISA Kit

MBS2610656-10x96StripWells 10x96-Strip-Wells
EUR 3040

Human Betacellulin (BTC) ELISA Kit

MBS2610656-48StripWells 48-Strip-Wells
EUR 285

Human Betacellulin (BTC) ELISA Kit

MBS2610656-5x96StripWells 5x96-Strip-Wells
EUR 1670

Human Betacellulin (BTC) ELISA Kit

MBS2610656-96StripWells 96-Strip-Wells
EUR 405

Human Betacellulin (bTC) ELISA Kit

MBS457991-10x96Tests 10x96Tests
EUR 4890

Human Betacellulin (bTC) ELISA Kit

MBS457991-48Tests 48Tests
EUR 425

Human Betacellulin (bTC) ELISA Kit

MBS457991-5x96Tests 5x96Tests
EUR 2495

Human Betacellulin (bTC) ELISA Kit

MBS457991-96Tests 96Tests
EUR 560

Human Betacellulin(BTC) ELISA Kit

EIA07641h each
EUR 430

Recombinant Human Betacellulin, HEK

cyt-1188-10g 10µg
EUR 145

Recombinant Human Betacellulin, HEK

cyt-1188-1mg 1mg
EUR 5200

Recombinant Human Betacellulin, HEK

cyt-1188-2g 2µg
EUR 60

Recombinant Human Betacellulin, HEK

MBS147328-0002mg 0.002mg
EUR 240

Recombinant Human Betacellulin, HEK

MBS147328-001mg 0.01mg
EUR 310

Recombinant Human Betacellulin, HEK

MBS147328-1mg 1mg
EUR 5345

Recombinant Human Betacellulin, HEK

MBS147328-5x1mg 5x1mg
EUR 23725

Anti-BTC/Betacellulin Antibody

MBS2400715-005mg 0.05mg
EUR 595

Anti-BTC/Betacellulin Antibody

MBS2400715-5x005mg 5x0.05mg
EUR 2500

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-24Tests 24 Tests
EUR 180
Description: Sandwich

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-48Tests 48 Tests
EUR 546
Description: Sandwich

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-96Tests 96 Tests
EUR 682
Description: Sandwich

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Human BTC -Betacellulin- CLIA Kit

E-CL-H0444-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Human bTC (Betacellulin) CLIA Kit

MBS2531178-5x96Tests 5x96Tests
EUR 2565

Human bTC (Betacellulin) CLIA Kit

MBS2531178-96Tests 96Tests
EUR 560

Human Betacellulin Protein, Fc Tag

BEN-H525x 1mg
EUR 374.5
Description: Human Betacellulin, Fc Tag (BEN-H525x) is expressed from human 293 cells (HEK293). It contains AA Asp 32 - Tyr 111 (Accession # AAH11618).

Human BTC(Betacellulin) ELISA Kit

EH0044 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human BTC (Betacellulin) ELISA Kit

EKE60392-5x96T 5x96T
EUR 3124.08

Human BTC (Betacellulin) ELISA Kit

EKE60392-96T 96T
EUR 657.7

Human bTC(Betacellulin) ELISA Kit

ELK1403-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human bTC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human bTC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human bTC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human bTC in the samples is then determined by comparing the OD of the samples to the standard curve.

Human bTC(Betacellulin) ELISA Kit

ELK1403-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human bTC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human bTC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human bTC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human bTC in the samples is then determined by comparing the OD of the samples to the standard curve.

Human BTC(Betacellulin) ELISA Kit

RE2928H-48wells 48 wells
EUR 116.55

Human BTC(Betacellulin) ELISA Kit

RE2928H-96wells 96 wells
EUR 161.55

Human bTC (Betacellulin) ELISA Kit

MBS8800404-10x96StripWells 10x96-Strip-Wells
EUR 3130

Human bTC (Betacellulin) ELISA Kit

MBS8800404-48StripWells 48-Strip-Wells
EUR 350

Human bTC (Betacellulin) ELISA Kit

MBS8800404-5x96StripWells 5x96-Strip-Wells
EUR 1710

Human bTC (Betacellulin) ELISA Kit

MBS8800404-96StripWells 96-Strip-Wells
EUR 445

Human bTC (Betacellulin) ELISA Kit

MBS2505147-10x96Tests 10x96Tests
EUR 4060

Human bTC (Betacellulin) ELISA Kit

MBS2505147-24Tests 24Tests
EUR 265

Human bTC (Betacellulin) ELISA Kit

MBS2505147-48Tests 48Tests
EUR 450

Human bTC (Betacellulin) ELISA Kit

MBS2505147-5x96Tests 5x96Tests
EUR 2265

Human bTC (Betacellulin) ELISA Kit

MBS2505147-96Tests 96Tests
EUR 535

Anti-Mouse Betacellulin Antibody

103-M308 100 µg
EUR 399
Description: Betacellulin (BTC) is a new member of the EGF family of cytokines that is comprised of at least ten proteins including EGF, TGFα, amphiregulin, HB-EGF, and the various heregulins. All of these cytokines are synthesized as transmembrane precursors and are characterized by the presence of one or more EGF structural units in their extracellular domain. The soluble forms of these cytokines are released by proteolytic cleavage. BTC, a heparin binding protein, was originally isolated from the conditioned media of mouse pancreatic beta tumor cells as a 32 kDa glycoprotein composed of 80 amino acid residues. The cDNA encoding human BTC was cloned from a human breast adenocarcinoma cell line (MCF7) cDNA library. Human and mouse cDNAs encode BTC precursor proteins of 178 and 177 amino acid residues, respectively. At the amino acid sequence level, human BTC precursor protein exhibits 79% identity with that of the mouse BTC precursor. In a mouse cell line transfected with human BTC cDNA, three forms of soluble human BTC have been detected: the glycosylated, intact BTC composed of 80 amino acid residues, a truncated molecule lacking 12 amino acid residues from the amino terminus, and a second truncated molecule lacking 30 amino acid residues from the amino-terminus. The biological activities of these BTC forms were shown to be identical. BTC can bind to the EGF receptor and is a potent mitogen for Balb/c 3T3 fibroblasts, retinal pigment epithelial cells and vascular smooth muscle cells.

BTC (untagged)-Human betacellulin (BTC)

SC309035 10 µg Ask for price

Human Betacellulin Recombinant Protein

100-332 20 µg
EUR 196.35
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Human Betacellulin Recombinant Protein

100-332S 5 µg
EUR 92.4
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Recombinant Human Betacellulin Protein

PROTP35070-2 20ug
EUR 380.4
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Recombinant Human Betacellulin protein

CD02256-5ug 5ug
EUR 176
Description: Betacellulin (BTC) is a member of the EGF family of cytokines that also includes EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. It is expressed in most tissues including kidney, uterus, liver and pancreas. BTC also presents in body fluids, including serum, milk, and colostrum. At the amino acid sequence level, human mature BTC protein exhibits 80 % identity with mouse BTC protein. The protein binds to EGFR, ERBB4 and other EGF receptor family members and acts as a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.

Betacellulin (bTC) Polyclonal Antibody (Human)

4-PAA112Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC)

Betacellulin (Human) LumiAb ELISA Kit

MBS9510760-1x96Wells 1x96Wells
EUR 520

Betacellulin (Human) LumiAb ELISA Kit

MBS9510760-5x96Wells 5x96Wells
EUR 2395

Betacellulin (HEK293-expressed), Human

HY-P7328 10ug
EUR 280.8

Human Betacellulin (bTC) Protein (Active)

20-abx655563
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Betacellulin (bTC) Protein (Active)

abx655563-50g 50 µg
EUR 3712.5

Nori® Human Betacellulin ELISA Kit

GR106276 96-well
EUR 461

Recombinant Human Betacellulin, His Tag

cyt-077-10g 10µg
EUR 145

Recombinant Human Betacellulin, His Tag

cyt-077-1mg 1mg
EUR 5200

Recombinant Human Betacellulin, His Tag

cyt-077-2g 2µg
EUR 60

Recombinant Human Betacellulin, His Tag

MBS144451-0002mg 0.002mg
EUR 240

Recombinant Human Betacellulin, His Tag

MBS144451-001mg 0.01mg
EUR 310

Recombinant Human Betacellulin, His Tag

MBS144451-1mg 1mg
EUR 5345

Recombinant Human Betacellulin, His Tag

MBS144451-5x1mg 5x1mg
EUR 23725

CLIA kit for Human BTC (Betacellulin)

E-CL-H0444 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

Betacellulin antibody

70R-BR013 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal Betacellulin antibody

Betacellulin antibody

MBS535912-005mg 0.05mg
EUR 465

Betacellulin antibody

MBS535912-5x005mg 5x0.05mg
EUR 1945

Betacellulin (Human) OmniKine ELISA Kit

MBS9501832-1x96Wells 1x96Wells
EUR 500

Betacellulin (Human) OmniKine ELISA Kit

MBS9501832-5x96Wells 5x96Wells
EUR 2300

Betacellulin (Human) Sandwich ELISA Kit

OK-0105 1Kit
EUR 217
Description: Betacellulin (Human) Colorimetric Sandwich ELISA Kit

ELISA kit for Human BTC (Betacellulin)

E-EL-H0570 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human bTC (Betacellulin)

ELK1403 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Betacellulin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Betacellulin Human Recombinant, His Tag

rAP-0361 Inquiry Ask for price

Sheep Polyclonal anti-human Betacellulin (BTC)

hAP-5047 50ug
EUR 400

Sheep Polyclonal anti-Human Betacellulin (BTC)

hAP-5649 50ug
EUR 400

BTC (GFP-tagged) - Human betacellulin (BTC)

RG202483 10 µg Ask for price

Betacellulin (bTC) Polyclonal Antibody (Human), PE

4-PAA112Hu01-PE
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with PE.

Betacellulin (BTC)

THP-0274 1 vial
EUR 3198.4
Description: Protein

Betacellulin (bTC) Polyclonal Antibody (Human), APC

4-PAA112Hu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with APC.

Betacellulin (bTC) Polyclonal Antibody (Human), Cy3

4-PAA112Hu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with Cy3.

Betacellulin (bTC) Polyclonal Antibody (Human), HRP

4-PAA112Hu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with HRP.

Recombinant Human Betacellulin/BTC Protein

RP01700 10μg
EUR 162.5

Recombinant human Betacellulin/BTC Protein

MBS201329-001mg 0.01mg
EUR 255

Recombinant human Betacellulin/BTC Protein

MBS201329-002mg 0.02mg
EUR 345

Recombinant human Betacellulin/BTC Protein

MBS201329-005mg 0.05mg
EUR 415

Recombinant human Betacellulin/BTC Protein

MBS201329-01mg 0.1mg
EUR 610

Recombinant human Betacellulin/BTC Protein

MBS201329-025mg 0.25mg
EUR 985

Human Betacellulin/BTC PicoKine ELISA Kit

EK0980 96 wells
EUR 510
Description: For quantitative detection of human Betacellulin in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human Betacellulin/BTC PicoKine ELISA Kit

MBS177180-5x96StripWells 5x96-Strip-Wells
EUR 2755

Human Betacellulin/BTC PicoKine ELISA Kit

MBS177180-96StripWells 96-Strip-Wells
EUR 600

Betacellulin (bTC) Polyclonal Antibody (Human), FITC

4-PAA112Hu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with FITC.

Betacellulin, Mouse

HY-P7329 50ug
EUR 734.4

Mouse Betacellulin

MBS691628-0005mg 0.005mg
EUR 300

Mouse Betacellulin

MBS691628-002mg 0.02mg
EUR 450

Mouse Betacellulin

MBS691628-5x002mg 5x0.02mg
EUR 1725

BTC Betacellulin Human Recombinant Protein

PROTP35070-1 Regular: 20ug
EUR 380.4
Description: Betacellulin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 80 amino acids and having a molecular mass of 9 kDa. ;Betacellulin Human Recombinant is purified by proprietary chromatographic techniques.

Rat Monoclonal anti-mouse Betacellulin

mAP-0154 100ug
EUR 250
The multi-targeted nanosystem confirmed significantly better uptake, increased PE38 expression, and subsequent cell loss of life in MDA-MB-231/HER2+ in comparison with MCF-10A. Nevertheless, the efficacy of our focused toxin gene remedy was decrease in MDA-MB-231/HER2+ spheroids in contrast with that within the monolayer tradition. the mixture of the cell floor, transcriptional, and translational concentrating on elevated the stringency of the remedy.

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