Exploiting Single-Cell Tools in Gene and Cell Therapy

Exploiting Single-Cell Tools in Gene and Cell Therapy

Single-cell molecular instruments have been developed at an unimaginable tempo over the past 5 years as sequencing prices proceed to drop and quite a few molecular assays have been coupled to sequencing readouts. This fast interval of technological growth has facilitated the delineation of particular person molecular traits together with the genome, transcriptome, epigenome, and proteome of particular person cells, resulting in an unprecedented decision of the molecular networks governing complicated organic techniques.
The immense energy of single-cell molecular screens has been significantly highlighted by work in techniques the place mobile heterogeneity is a key characteristic, similar to stem cell biology, immunology, and tumor cell biology. Single-cell-omics applied sciences have already contributed to the identification of novel illness biomarkers, mobile subsets, therapeutic targets and diagnostics, a lot of which might have been undetectable by bulk sequencing approaches.
Extra not too long ago, efforts to combine single-cell multi-omics with single cell purposeful output and/or bodily location have been difficult however have led to substantial advances. Maybe most excitingly, there are rising alternatives to succeed in past the outline of static mobile states with current advances in modulation of cells by CRISPR expertise, particularly with the event of base editors which tremendously raises the prospect of cell and gene therapies.
On this overview, we offer a short overview of rising single-cell applied sciences and focus on present developments in integrating single-cell molecular screens and performing single-cell multi-omics for medical functions. We additionally focus on how single-cell molecular assays may be usefully mixed with purposeful information to unpick the mechanism of mobile decision-making. Lastly, we mirror upon the introduction of spatial transcriptomics and proteomics, its complementary function with single-cell RNA sequencing (scRNA-seq) and potential software in mobile and gene remedy.

Vector Methods to Actualize B Cell-Based mostly Gene Therapies

Latest developments in genome enhancing and supply techniques have opened new prospects for B cell gene remedy. CRISPR-Cas9 nucleases have been used to introduce transgenes into B cell genomes for subsequent secretion of exogenous therapeutic proteins from plasma cells and to program novel B cell Ag receptor specificities, permitting for the era of fascinating Ab responses that can’t usually be elicited in animal fashions.
Genome modification of B cells or their progenitor, hematopoietic stem cells, might probably substitute Ab or protein alternative therapies that require a number of injections over the long run. Thus far, B cell enhancing utilizing CRISPR-Cas9 has been solely employed in preclinical research, through which cells are edited ex vivo. On this overview, we focus on present B cell engineering efforts and techniques for the eventual protected and economical adoption of modified B cells into the clinic, together with in vivo viral supply of enhancing reagents to B cells.
 Exploiting Single-Cell Tools in Gene and Cell Therapy

Analytics of host cell proteins (HCPs): classes from biopharmaceutical mAb evaluation for Gene remedy merchandise

Analytics for host cell protein (HCP) evaluation of therapeutic monoclonal antibody preparations have developed enormously. We think about how learnings from this could inform HCP evaluation of gene remedy viral vector merchandise. The appliance of mass spectrometry (MS) approaches for evaluation of HCPs in viral vector preparations is being established, though such data stays restricted and is but to be extensively utilized into course of or host cell line growth to cut back HCP quantities or danger.
As these MS approaches, and the information from them, are utilized and develop into accessible, the method understanding created will velocity course of growth exercise. We describe applied sciences which were, or may be, utilized to viral vector HCP evaluation to assist course of growth, scale back HCP quantities, determine crucial HCPs and thus inform danger evaluation and administration primarily based on a information of particular HCPs, in the end delivering protected and efficacious gene remedy merchandise to the clinic.

An optimum non-viral gene switch methodology for genetically modifying porcine bone marrow-derived endothelial progenitor cells for experimental therapeutics

No presently accessible therapy is ready to generate new contractile tissue or considerably enhance cardiac operate after myocardial infarction (MI), a number one reason behind morbidity and mortality worldwide. Though gene transfer-enhanced endothelial progenitor cells (GTE-EPCs) present effectiveness in MI therapy in small animal fashions, no medical trials utilizing GTE-EPCs have been documented. Earlier than the introduction of GTE-EPCs into human trials, gene-transfer-mediated augmentation of EPC operate in animal fashions that mirror the human MI state of affairs ought to be examined.
On this regard, a porcine mannequin is your best option since pigs have cardiac dimension, hemodynamics and coronary anatomy just like that of people. To look at GTE-EPC therapeutic efficacy in pig MI fashions, an environment friendly methodology for gene switch into pig EPCs is required, which nevertheless, has been poorly documented. Pig bone marrow mononuclear cells have been remoted and cultured in EGM-2 medium to acquire bone marrow-derived EPCs (BM-EPCs) that have been characterised by immunostaining and the tube formation assay.
Gene switch was optimized in 6-well plates utilizing a GFP and a VEGF plasmid, and scaled up in T75 flasks. Gene switch effectivity was decided by fluorescence microscopy and stream cytometry. VEGF ranges have been measured by ELISA. Cell proliferation was assayed by the CCK-Eight equipment. (1) BM-EPCs expressed VEGFR2 and eNOS however not CD45 protein, and shaped tube buildings on Matrigel; (2) a number of chemical compounds have been explored with the very best transfection effectivity of 41.4% ± 5.8% achieved utilizing Lipofectamine 3000; (3) the VEGF stage in tradition medium after VEGF transfection was 378 ± 48 ng/106 cells; and (4) BM-EPCs overexpressing VEGF had considerably enhanced proliferation than GFP-transfected EPCs.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-Betacellulin/Btc Antibody

A02171-1 100ug/vial
EUR 334

Betacellulin, murine (mouse)

RC238-23 5ug
EUR 104.38

Betacellulin (HEK293-expressed), Mouse

HY-P7142 50ug
EUR 533

Mouse Betacellulin (bTC) Protein

20-abx065525
  • EUR 732.00
  • EUR 286.00
  • EUR 2305.00
  • EUR 885.00
  • EUR 523.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin, human

RC218-23 5ug
EUR 104.38

Betacellulin, Human

HY-P7005 10ug
EUR 211

Bovine Betacellulin

ARU020 20 µg
EUR 253

Bovine Betacellulin

ARU100 100 µg
EUR 346

Betacellulin antibody

70R-BR013 50 ug
EUR 273
Description: Affinity purified Rabbit polyclonal Betacellulin antibody

Betacellulin protein

30R-AB028 20 ug
EUR 273
Description: Purified recombinant Human Betacellulin protein

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-10x96wellstestplate 10x96-wells test plate
EUR 3710.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-1x48wellstestplate 1x48-wells test plate
EUR 393.22
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-1x96wellstestplate 1x96-wells test plate
EUR 518.88
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-5x96wellstestplate 5x96-wells test plate
EUR 2034.96
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

4-SEA112Mu
  • EUR 3761.00
  • EUR 1985.00
  • EUR 519.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Betacellulin (bTC) Polyclonal Antibody (Mouse)

4-PAA112Mu01
  • EUR 214.00
  • EUR 1995.00
  • EUR 508.00
  • EUR 263.00
  • EUR 200.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC)

BTC Betacellulin Mouse Recombinant Protein

PROTQ05928 Regular: 20ug
EUR 317
Description: BTC Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 80 amino acids and having a molecular mass of 9.0kDa. ;The BTC is purified by proprietary chromatographic techniques.

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-48Tests 48 Tests
EUR 426

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-96Tests 96 Tests
EUR 587

Mouse Betacellulin (bTC) ELISA Kit

DLR-bTC-Mu-48T 48T
EUR 433
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

DLR-bTC-Mu-96T 96T
EUR 558
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin (BTC) ELISA Kit

abx574631-96tests 96 tests
EUR 668

Mouse Betacellulin (BTC) ELISA Kit

abx253974-96tests 96 tests
EUR 668

Mouse Betacellulin (BTC) ELISA Kit

20-abx153708
  • EUR 6047.00
  • EUR 3228.00
  • EUR 754.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Betacellulin (BTC) CLIA Kit

20-abx491044
  • EUR 7378.00
  • EUR 3933.00
  • EUR 911.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-48Tests 48 Tests
EUR 445

Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-96Tests 96 Tests
EUR 614

Recombinant Betacellulin (bTC)

4-RPA112Hu01
  • EUR 458.40
  • EUR 226.00
  • EUR 1444.00
  • EUR 548.00
  • EUR 996.00
  • EUR 370.00
  • EUR 3460.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Betacellulin expressed in: E.coli

Recombinant Betacellulin (bTC)

4-RPA112Mu01
  • EUR 530.08
  • EUR 245.00
  • EUR 1712.80
  • EUR 637.60
  • EUR 1175.20
  • EUR 418.00
  • EUR 4132.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Betacellulin expressed in: E.coli

Betacellulin (BTC) Antibody

20-abx111218
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Betacellulin (bTC) Antibody

20-abx100739
  • EUR 342.00
  • EUR 133.00
  • EUR 982.00
  • EUR 495.00
  • EUR 286.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody

20-abx100740
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Recombinant Human Betacellulin

7-00223 5µg Ask for price

Recombinant Human Betacellulin

7-00224 20µg Ask for price

Recombinant Human Betacellulin

7-00225 1mg Ask for price

Recombinant Bovine Betacellulin

7-00226 5µg Ask for price

Recombinant Bovine Betacellulin

7-00227 20µg Ask for price

Recombinant Bovine Betacellulin

7-00228 1mg Ask for price

Betacellulin (bTC) Antibody

20-abx175568
  • EUR 1135.00
  • EUR 551.00
  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175569
  • EUR 1177.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175570
  • EUR 1177.00
  • EUR 578.00
  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175571
  • EUR 1288.00
  • EUR 620.00
  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx171411
  • EUR 787.00
  • EUR 411.00
  • 1 mg
  • 200 ug

Betacellulin (BTC) Antibody

abx230883-100ug 100 ug
EUR 481

Betacellulin Recombinant Protein

40-192-0005mg 0.005 mg
EUR 259.25
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Betacellulin Recombinant Protein

40-192-002mg 0.02 mg
EUR 364.25
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Betacellulin Recombinant Protein

96-830 0.05 mg
EUR 595.25
Description: Probetacellulin can be cleaved into the Betacellulin (BTC) that is a single-pass type I membrane protein containing 1 EGF-like domain. Predominantly expressed in pancreas and small intestine,Betacellulin (BTC) is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. As a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells, Betacellulin (BTC) is also the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Betacellulin (BTC) was originally identified as a growth-promoting factor in mouse pancreatic beta-cell carcinoma cell line and has since been identified in humans. The amino acid sequence of mature mBTC is 82.5%, identical with that of human BTC (hBTC), and both exhibit significant overall similarity with other members of the EGF family.

Betacellulin Recombinant Protein

40-578-0005mg 0.005 mg
EUR 259.25
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Betacellulin Recombinant Protein

40-578-002mg 0.02 mg
EUR 364.25
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Betacellulin, Murine Recombinant

7119-10
EUR 196

Betacellulin, Murine Recombinant

7119-50
EUR 675

Betacellulin Recombinant Protein

91-592 0.05 mg
EUR 542.75
Description: Mouse Betacellulin is a single type I membrane protein which belongs to the EGF family of cytokines. EGF family has many members including EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. Betacellulin is characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin is expressed in several tissues and tumor cells including kidney, uterus, liver, pancreas and small intestine. Betacellulin binds and activates ErbB-1 and ErbB-4 homodimers. Betacellulin is thought to play a role in the differentiation of pancreatic beta cells.Human and mouse mature BTC protein are 80% identical at the amino acid sequence level. Betacellulin is involved in many biological processes such as stimulating gastrointestinal growth. It is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types.

Betacellulin (bTC) Polyclonal Antibody (Mouse), APC

4-PAA112Mu01-APC
  • EUR 296.00
  • EUR 2573.00
  • EUR 737.00
  • EUR 369.00
  • EUR 198.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with APC.

Betacellulin (bTC) Polyclonal Antibody (Mouse), Biotinylated

4-PAA112Mu01-Biotin
  • EUR 275.00
  • EUR 1945.00
  • EUR 598.00
  • EUR 329.00
  • EUR 204.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with Biotin.

Betacellulin (bTC) Polyclonal Antibody (Mouse), Cy3

4-PAA112Mu01-Cy3
  • EUR 353.00
  • EUR 3389.00
  • EUR 941.00
  • EUR 451.00
  • EUR 223.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with Cy3.

Betacellulin (bTC) Polyclonal Antibody (Mouse), FITC

4-PAA112Mu01-FITC
  • EUR 256.00
  • EUR 2078.00
  • EUR 609.00
  • EUR 315.00
  • EUR 179.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with FITC.

Betacellulin (bTC) Polyclonal Antibody (Mouse), HRP

4-PAA112Mu01-HRP
  • EUR 273.00
  • EUR 2246.00
  • EUR 655.00
  • EUR 337.00
  • EUR 188.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with HRP.

Betacellulin (bTC) Polyclonal Antibody (Mouse), PE

4-PAA112Mu01-PE
  • EUR 256.00
  • EUR 2078.00
  • EUR 609.00
  • EUR 315.00
  • EUR 179.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with PE.

ELISA kit for Mouse BTC (Betacellulin)

E-EL-M0181 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Mouse BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Mouse BTC (Betacellulin)

E-CL-M0133 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Mouse BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse bTC (Betacellulin)

ELK1236 1 plate of 96 wells
EUR 372
Description: A sandwich ELISA kit for detection of Betacellulin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Mouse Betacellulin/BTC PicoKine ELISA Kit

EK1193 96 wells
EUR 425
Description: For quantitative detection of mouse BTC in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Betacellulin/BTC ELISA Kit (Mouse) (OKBB00530)

OKBB00530 96 Wells
EUR 505
Description: Description of target: Betacellulin, also known as BTC is a protein that in humans is encoded by the BTC gene. This gene is mapped to 4q13.3. The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. It is the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. This protein is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

ELISA kit for Mouse Betacellulin/BTC

EK5523 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Betacellulin/BTC in samples from serum, plasma, tissue homogenates and other biological fluids.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-10ug 10ug
EUR 156
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-1mg 1mg
EUR 2283
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-500ug 500ug
EUR 1613
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-50ug 50ug
EUR 369
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Murine Betacellulin Protein

PROTQ05928-1 20ug
EUR 317
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Recombinant Human Betacellulin Protein

PROTP35070-2 20ug
EUR 317
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Rat Betacellulin antiserum (Rabbit)

PAAQ1 100 µl
EUR 299

Bovine Betacellulin antiserum (Rabbit)

PAAR1 100 µl
EUR 299

Betacellulin (HEK293-expressed), Human

HY-P7328 10ug
EUR 234

Rat Betacellulin (bTC) Protein

20-abx652663
  • EUR 578.00
  • EUR 258.00
  • EUR 1720.00
  • EUR 690.00
  • EUR 425.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cow Betacellulin (bTC) Protein

20-abx652665
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Chicken Betacellulin (bTC) Protein

20-abx652666
  • EUR 648.00
  • EUR 272.00
  • EUR 1998.00
  • EUR 773.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Betacellulin (bTC) Protein

20-abx065524
  • EUR 648.00
  • EUR 272.00
  • EUR 1943.00
  • EUR 759.00
  • EUR 467.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody (FITC)

20-abx274036
  • EUR 411.00
  • EUR 230.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody (Biotin)

20-abx271925
  • EUR 425.00
  • EUR 230.00
  • EUR 1191.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody (Biotin)

20-abx272658
  • EUR 384.00
  • EUR 230.00
  • EUR 1052.00
  • EUR 523.00
  • EUR 300.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA112Mu01-APC-Cy7
  • EUR 472.00
  • EUR 5026.00
  • EUR 1354.00
  • EUR 619.00
  • EUR 277.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with APC-Cy7.

Mouse Betacellulin/BTC(Beta Cellulin) ELISA Kit

EM0021 96T
EUR 567.6
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-10x96wellstestplate 10x96-wells test plate
EUR 4273.35
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-1x48wellstestplate 1x48-wells test plate
EUR 439.57
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-1x96wellstestplate 1x96-wells test plate
EUR 585.1
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-5x96wellstestplate 5x96-wells test plate
EUR 2332.95
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

4-SEA112Hu
  • EUR 4324.00
  • EUR 2283.00
  • EUR 586.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Betacellulin (bTC) Polyclonal Antibody (Human)

4-PAA112Hu01
  • EUR 232.00
  • EUR 2285.00
  • EUR 574.00
  • EUR 289.00
  • EUR 208.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC)

Betacellulin (bTC) Polyclonal Antibody (Rat)

4-PAA112Ra01
  • EUR 243.00
  • EUR 2450.00
  • EUR 611.00
  • EUR 304.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC)

BTC Betacellulin Bovine Recombinant Protein

PROTQ9TTC5 Regular: 20ug
EUR 317
Description: Betacellulin Bovine Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 80 amino acids and having a molecular mass of 9003 Dalton. ;Betacellulin Bovine Recombinant is purified by proprietary chromatographic techniques.

BTC Betacellulin Human Recombinant Protein

PROTP35070-1 Regular: 20ug
EUR 317
Description: Betacellulin Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 80 amino acids and having a molecular mass of 9 kDa. ;Betacellulin Human Recombinant is purified by proprietary chromatographic techniques.

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-48Tests 48 Tests
EUR 478

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-96Tests 96 Tests
EUR 662

Rat Betacellulin (bTC) ELISA Kit

RD-bTC-Ra-48Tests 48 Tests
EUR 511

Rat Betacellulin (bTC) ELISA Kit

RD-bTC-Ra-96Tests 96 Tests
EUR 709

Human Betacellulin, BTC ELISA Kit

DEIA089 10 plates
EUR 2605
Description: This assay is a sandwich Enzyme Linked-Immuno-Sorbent Assay (ELISA). It is developed for quantitative measurement of human BTC in serum, plasma and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu-48T 48T
EUR 479
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu-96T 96T
EUR 621
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Rat Betacellulin (bTC) ELISA Kit

DLR-bTC-Ra-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Rat Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates,cell culture supernates or other biological fluids.

Rat Betacellulin (bTC) ELISA Kit

DLR-bTC-Ra-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Rat Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates,cell culture supernates or other biological fluids.

Human Betacellulin (BTC) ELISA Kit

abx570040-96tests 96 tests
EUR 668

Chicken Betacellulin (BTC) ELISA Kit

abx574267-96tests 96 tests
EUR 825

Cow Betacellulin (BTC) ELISA Kit

abx575529-96tests 96 tests
EUR 911

Rabbit Betacellulin (BTC) ELISA Kit

abx363832-96tests 96 tests
EUR 825

Pig Betacellulin (BTC) ELISA Kit

abx361663-96tests 96 tests
EUR 825

Monkey Betacellulin (BTC) ELISA Kit

abx359865-96tests 96 tests
EUR 825

Human Betacellulin (bTC) Protein (Active)

20-abx655563
  • EUR 1024.00
  • EUR 356.00
  • EUR 3376.00
  • EUR 1233.00
  • EUR 704.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Rat Betacellulin (BTC) ELISA Kit

abx576495-96tests 96 tests
EUR 825

Human Betacellulin (bTC) CLIA Kit

abx196482-96tests 96 tests
EUR 825

Human Betacellulin (BTC) ELISA Kit

abx250182-96tests 96 tests
EUR 668

Rat Betacellulin (BTC) ELISA Kit

abx255590-96tests 96 tests
EUR 668

Human Betacellulin (BTC) CLIA Kit

20-abx491043
  • EUR 7973.00
  • EUR 4246.00
  • EUR 981.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-48Tests 48 Tests
EUR 500

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-96Tests 96 Tests
EUR 692

Rat Betacellulin (bTC) ELISA Kit

RDR-bTC-Ra-48Tests 48 Tests
EUR 534

Rat Betacellulin (bTC) ELISA Kit

RDR-bTC-Ra-96Tests 96 Tests
EUR 742

Human BTC(Betacellulin) ELISA Kit

EH0044 96T
EUR 524.1
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human Betacellulin/BTC ELISA Kit

LF-EK50996 1×96T
EUR 648

Betacellulin/BTC ELISA Kit| Mouse Beta Cellulin ELISA Kit

EF012837 96 Tests
EUR 689

Betacellulin (bTC) Polyclonal Antibody (Human), APC

4-PAA112Hu01-APC
  • EUR 323.00
  • EUR 2969.00
  • EUR 836.00
  • EUR 409.00
  • EUR 210.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with APC.

Betacellulin (bTC) Polyclonal Antibody (Human), Biotinylated

4-PAA112Hu01-Biotin
  • EUR 295.00
  • EUR 2235.00
  • EUR 671.00
  • EUR 358.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with Biotin.

Betacellulin (bTC) Polyclonal Antibody (Human), Cy3

4-PAA112Hu01-Cy3
  • EUR 390.00
  • EUR 3917.00
  • EUR 1073.00
  • EUR 504.00
  • EUR 239.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with Cy3.

Betacellulin (bTC) Polyclonal Antibody (Human), FITC

4-PAA112Hu01-FITC
  • EUR 279.00
  • EUR 2395.00
  • EUR 688.00
  • EUR 347.00
  • EUR 188.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with FITC.

Betacellulin (bTC) Polyclonal Antibody (Human), HRP

4-PAA112Hu01-HRP
  • EUR 297.00
  • EUR 2589.00
  • EUR 741.00
  • EUR 371.00
  • EUR 199.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with HRP.

Betacellulin (bTC) Polyclonal Antibody (Human), PE

4-PAA112Hu01-PE
  • EUR 279.00
  • EUR 2395.00
  • EUR 688.00
  • EUR 347.00
  • EUR 188.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with PE.

Betacellulin (bTC) Polyclonal Antibody (Rat), APC

4-PAA112Ra01-APC
  • EUR 340.00
  • EUR 3194.00
  • EUR 892.00
  • EUR 431.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC). This antibody is labeled with APC.

Betacellulin (bTC) Polyclonal Antibody (Rat), Biotinylated

4-PAA112Ra01-Biotin
  • EUR 307.00
  • EUR 2400.00
  • EUR 712.00
  • EUR 375.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC). This antibody is labeled with Biotin.

Betacellulin (bTC) Polyclonal Antibody (Rat), Cy3

4-PAA112Ra01-Cy3
  • EUR 411.00
  • EUR 4217.00
  • EUR 1148.00
  • EUR 534.00
  • EUR 247.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC). This antibody is labeled with Cy3.

Betacellulin (bTC) Polyclonal Antibody (Rat), FITC

4-PAA112Ra01-FITC
  • EUR 292.00
  • EUR 2575.00
  • EUR 733.00
  • EUR 365.00
  • EUR 193.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC). This antibody is labeled with FITC.

Betacellulin (bTC) Polyclonal Antibody (Rat), HRP

4-PAA112Ra01-HRP
  • EUR 311.00
  • EUR 2784.00
  • EUR 789.00
  • EUR 390.00
  • EUR 204.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC). This antibody is labeled with HRP.

Betacellulin (bTC) Polyclonal Antibody (Rat), PE

4-PAA112Ra01-PE
  • EUR 292.00
  • EUR 2575.00
  • EUR 733.00
  • EUR 365.00
  • EUR 193.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC). This antibody is labeled with PE.

CLIA kit for Human BTC (Betacellulin)

E-CL-H0444 1 plate of 96 wells
EUR 584
Description: A sandwich CLIA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human bTC (Betacellulin)

ELK1403 1 plate of 96 wells
EUR 432
Description: A sandwich ELISA kit for detection of Betacellulin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human BTC (Betacellulin)

E-EL-H0570 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat BTC (Betacellulin)

E-EL-R0101 1 plate of 96 wells
EUR 534
Description: A sandwich ELISA kit for quantitative measurement of Rat BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

Human Betacellulin/BTC PicoKine ELISA Kit

EK0980 96 wells
EUR 425
Description: For quantitative detection of human Betacellulin in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Guinea pig Betacellulin (BTC) ELISA Kit

abx357846-96tests 96 tests
EUR 825

ELISA kit for Human Betacellulin/BTC

EK5454 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Betacellulin/BTC in samples from serum, plasma, tissue homogenates and other biological fluids.

ELISA kit for Rat Betacellulin/BTC

EK5582 96 tests
EUR 553
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Betacellulin/BTC in samples from serum, plasma, tissue homogenates and other biological fluids.

Nori® Human Betacellulin ELISA Kit

GR106276 96-well
EUR 461

Human Probetacellulin [Cleaved into: Betacellulin protein (BTC)

1-CSB-EP002853HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Probetacellulin [Cleaved into: Betacellulin protein(BTC) expressed in E.coli

Betacellulin (bTC) Polyclonal Antibody (Human), APC-Cy7

4-PAA112Hu01-APC-Cy7
  • EUR 527.00
  • EUR 5818.00
  • EUR 1552.00
  • EUR 698.00
  • EUR 301.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC). This antibody is labeled with APC-Cy7.

Betacellulin (bTC) Polyclonal Antibody (Rat), APC-Cy7

4-PAA112Ra01-APC-Cy7
  • EUR 560.00
  • EUR 6268.00
  • EUR 1664.00
  • EUR 743.00
  • EUR 314.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC). This antibody is labeled with APC-Cy7.

BTC Betacellulin Human Recombinant Protein, His Tag

PROTP35070 Regular: 10ug
EUR 317
Description: BTC Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 101 amino acids (32-111) and having a molecular mass of 11.3 kDa.;BTC is fused to a 21 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Betacellulin ELISA Kit (Human) : 96 Wells (OKAG00006)

OKAG00006 96 Wells
EUR 596
Description: Description of target: This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.;Species reactivity: Human;Application: ELISA;Assay info: Quantitative Colorimentric Sandwich ELISA;Sensitivity: 8 pg/mL

Recombinant Betacellulin Protein (Asp 32-Tyr 111) [Fc]

VAng-1124Lsx-1mg 1 mg
EUR 6099
Description: Human Betacellulin, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAH11618)

Recombinant Betacellulin Protein (Asp 32-Tyr 111) [Fc]

VAng-1124Lsx-50g 50 µg
EUR 1013
Description: Human Betacellulin, Fc tag, is expressed in HEK 293 cells. (Uniprot ID: AAH11618)

Nori® Human Betacellulin ELISA Kit (2 plates)

GR106276-2 2 x 96-well
EUR 832

Recombinant Human BTC/ Betacellulin Protein, Untagged, E.coli-100ug

QP10416-ec-100ug 100ug
EUR 988

Recombinant Human BTC/ Betacellulin Protein, Untagged, E.coli-20ug

QP10416-ec-20ug 20ug
EUR 290

Recombinant Human BTC/ Betacellulin Protein, Untagged, E.coli-250ug

QP10416-ec-250ug 250ug
EUR 1731

Recombinant Human BTC/ Betacellulin Protein, Untagged, E.coli-5ug

QP10416-ec-5ug 5ug
EUR 154

Recombinant Human BTC/ Betacellulin Protein, His, E.coli-100ug

QP5728-ec-100ug 100ug
EUR 418

Recombinant Human BTC/ Betacellulin Protein, His, E.coli-10ug

QP5728-ec-10ug 10ug
EUR 155

Recombinant Human BTC/ Betacellulin Protein, His, E.coli-1mg

QP5728-ec-1mg 1mg
EUR 1678

Recombinant Human BTC/ Betacellulin Protein, His, E.coli-200ug

QP5728-ec-200ug 200ug
EUR 635

Recombinant Human BTC/ Betacellulin Protein, His, E.coli-500ug

QP5728-ec-500ug 500ug
EUR 1053

Recombinant Human BTC/ Betacellulin Protein, His, E.coli-50ug

QP5728-ec-50ug 50ug
EUR 281

Recombinant Human BTC/ Betacellulin Protein, His, Yeast-100ug

QP5728-ye-100ug 100ug
EUR 418

Recombinant Human BTC/ Betacellulin Protein, His, Yeast-10ug

QP5728-ye-10ug 10ug
EUR 155

Recombinant Human BTC/ Betacellulin Protein, His, Yeast-1mg

QP5728-ye-1mg 1mg
EUR 1678

Recombinant Human BTC/ Betacellulin Protein, His, Yeast-200ug

QP5728-ye-200ug 200ug
EUR 635

Recombinant Human BTC/ Betacellulin Protein, His, Yeast-500ug

QP5728-ye-500ug 500ug
EUR 1053

Recombinant Human BTC/ Betacellulin Protein, His, Yeast-50ug

QP5728-ye-50ug 50ug
EUR 281

Mouse Anti-FcεRIα

MOFCeRIaAP(V100) 100 ug
EUR 50

Mouse Anti-FcεRIα

MOFCeRIaAP(V25) 25 ug
EUR 50

Mouse Anti-FcεRIα

MOFCeRIaB(V100) 100 ug
EUR 50

Mouse Anti-FcεRIα

MOFCeRIaB(V25) 25 ug
EUR 50

Mouse Anti-FcεRIα

MOFCeRIaCFB(V100) 100 ug
EUR 50

Mouse Anti-FcεRIα

MOFCeRIaCFB(V25) 25 ug
EUR 50

Mouse Anti-FcεRIα

MOFCeRIaF(V100) 100 ug
EUR 50
A easy, straightforward and low cost methodology that may be utilized to supply a lot of genetically-modified BM-EPCs was established, which can facilitate the research of GTE-EPC therapeutic efficacy in pig MI mannequin.

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