Exploiting Single-Cell Tools in Gene and Cell Therapy

Exploiting Single-Cell Tools in Gene and Cell Therapy

Single-cell molecular instruments have been developed at an unimaginable tempo over the past 5 years as sequencing prices proceed to drop and quite a few molecular assays have been coupled to sequencing readouts. This fast interval of technological growth has facilitated the delineation of particular person molecular traits together with the genome, transcriptome, epigenome, and proteome of particular person cells, resulting in an unprecedented decision of the molecular networks governing complicated organic techniques.
The immense energy of single-cell molecular screens has been significantly highlighted by work in techniques the place mobile heterogeneity is a key characteristic, similar to stem cell biology, immunology, and tumor cell biology. Single-cell-omics applied sciences have already contributed to the identification of novel illness biomarkers, mobile subsets, therapeutic targets and diagnostics, a lot of which might have been undetectable by bulk sequencing approaches.
Extra not too long ago, efforts to combine single-cell multi-omics with single cell purposeful output and/or bodily location have been difficult however have led to substantial advances. Maybe most excitingly, there are rising alternatives to succeed in past the outline of static mobile states with current advances in modulation of cells by CRISPR expertise, particularly with the event of base editors which tremendously raises the prospect of cell and gene therapies.
On this overview, we offer a short overview of rising single-cell applied sciences and focus on present developments in integrating single-cell molecular screens and performing single-cell multi-omics for medical functions. We additionally focus on how single-cell molecular assays may be usefully mixed with purposeful information to unpick the mechanism of mobile decision-making. Lastly, we mirror upon the introduction of spatial transcriptomics and proteomics, its complementary function with single-cell RNA sequencing (scRNA-seq) and potential software in mobile and gene remedy.

Vector Methods to Actualize B Cell-Based mostly Gene Therapies

Latest developments in genome enhancing and supply techniques have opened new prospects for B cell gene remedy. CRISPR-Cas9 nucleases have been used to introduce transgenes into B cell genomes for subsequent secretion of exogenous therapeutic proteins from plasma cells and to program novel B cell Ag receptor specificities, permitting for the era of fascinating Ab responses that can’t usually be elicited in animal fashions.
Genome modification of B cells or their progenitor, hematopoietic stem cells, might probably substitute Ab or protein alternative therapies that require a number of injections over the long run. Thus far, B cell enhancing utilizing CRISPR-Cas9 has been solely employed in preclinical research, through which cells are edited ex vivo. On this overview, we focus on present B cell engineering efforts and techniques for the eventual protected and economical adoption of modified B cells into the clinic, together with in vivo viral supply of enhancing reagents to B cells.
 Exploiting Single-Cell Tools in Gene and Cell Therapy

Analytics of host cell proteins (HCPs): classes from biopharmaceutical mAb evaluation for Gene remedy merchandise

Analytics for host cell protein (HCP) evaluation of therapeutic monoclonal antibody preparations have developed enormously. We think about how learnings from this could inform HCP evaluation of gene remedy viral vector merchandise. The appliance of mass spectrometry (MS) approaches for evaluation of HCPs in viral vector preparations is being established, though such data stays restricted and is but to be extensively utilized into course of or host cell line growth to cut back HCP quantities or danger.
As these MS approaches, and the information from them, are utilized and develop into accessible, the method understanding created will velocity course of growth exercise. We describe applied sciences which were, or may be, utilized to viral vector HCP evaluation to assist course of growth, scale back HCP quantities, determine crucial HCPs and thus inform danger evaluation and administration primarily based on a information of particular HCPs, in the end delivering protected and efficacious gene remedy merchandise to the clinic.

An optimum non-viral gene switch methodology for genetically modifying porcine bone marrow-derived endothelial progenitor cells for experimental therapeutics

No presently accessible therapy is ready to generate new contractile tissue or considerably enhance cardiac operate after myocardial infarction (MI), a number one reason behind morbidity and mortality worldwide. Though gene transfer-enhanced endothelial progenitor cells (GTE-EPCs) present effectiveness in MI therapy in small animal fashions, no medical trials utilizing GTE-EPCs have been documented. Earlier than the introduction of GTE-EPCs into human trials, gene-transfer-mediated augmentation of EPC operate in animal fashions that mirror the human MI state of affairs ought to be examined.
On this regard, a porcine mannequin is your best option since pigs have cardiac dimension, hemodynamics and coronary anatomy just like that of people. To look at GTE-EPC therapeutic efficacy in pig MI fashions, an environment friendly methodology for gene switch into pig EPCs is required, which nevertheless, has been poorly documented. Pig bone marrow mononuclear cells have been remoted and cultured in EGM-2 medium to acquire bone marrow-derived EPCs (BM-EPCs) that have been characterised by immunostaining and the tube formation assay.
Gene switch was optimized in 6-well plates utilizing a GFP and a VEGF plasmid, and scaled up in T75 flasks. Gene switch effectivity was decided by fluorescence microscopy and stream cytometry. VEGF ranges have been measured by ELISA. Cell proliferation was assayed by the CCK-Eight equipment. (1) BM-EPCs expressed VEGFR2 and eNOS however not CD45 protein, and shaped tube buildings on Matrigel; (2) a number of chemical compounds have been explored with the very best transfection effectivity of 41.4% ± 5.8% achieved utilizing Lipofectamine 3000; (3) the VEGF stage in tradition medium after VEGF transfection was 378 ± 48 ng/106 cells; and (4) BM-EPCs overexpressing VEGF had considerably enhanced proliferation than GFP-transfected EPCs.

Mouse Betacellulin (BTC) ELISA Kit

abx574631-96tests 96 tests
EUR 801.6

Mouse Betacellulin (bTC) ELISA Kit

DLR-bTC-Mu-48T 48T
EUR 519.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

DLR-bTC-Mu-96T 96T
EUR 669.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin (BTC) ELISA Kit

20-abx153708
  • EUR 7256.40
  • EUR 3873.60
  • EUR 904.80
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-48Tests 48 Tests
EUR 534

Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-96Tests 96 Tests
EUR 736.8

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-48T 48T
EUR 361.7
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-96T 96T
EUR 516.7
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-10x96wellstestplate 10x96-wells test plate
EUR 4452.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-1x48wellstestplate 1x48-wells test plate
EUR 471.86
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-1x96wellstestplate 1x96-wells test plate
EUR 622.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-5x96wellstestplate 5x96-wells test plate
EUR 2441.95
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

4-SEA112Mu
  • EUR 4513.20
  • EUR 2382.00
  • EUR 622.80
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Betacellulin (bTC) ELISA Kit

EKN43809-48T 48T
EUR 294

Mouse Betacellulin (bTC) ELISA Kit

EKN43809-5x96T 5x96T
EUR 1995

Mouse Betacellulin (bTC) ELISA Kit

EKN43809-96T 96T
EUR 420

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-48Tests 48 Tests
EUR 511.2

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-96Tests 96 Tests
EUR 704.4

Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-48T 48T
EUR 379.79
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-96T 96T
EUR 542.54
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

DL-bTC-Mu 96T
EUR 353
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

DLR-bTC-Mu 96T
EUR 370
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

EKU02698-48T 48T
EUR 431.69

Mouse Betacellulin (bTC) ELISA Kit

EKU02698-5x96T 5x96T
EUR 2929.33

Mouse Betacellulin (bTC) ELISA Kit

EKU02698-96T 96T
EUR 616.7

ELISA kit for Mouse Betacellulin/BTC

EK5523 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Betacellulin/BTC in samples from serum, plasma, tissue homogenates and other biological fluids.

CLIA kit for Mouse BTC (Betacellulin)

E-CL-M0133 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Mouse BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

Betacellulin antibody

70R-BR013 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal Betacellulin antibody

Betacellulin (HEK293-expressed), Mouse

HY-P7142 50ug
EUR 639.6

ELISA kit for Mouse BTC (Betacellulin)

E-EL-M0181 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse bTC (Betacellulin)

ELK1236 1 plate of 96 wells
EUR 446.4
Description: A sandwich ELISA kit for detection of Betacellulin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Betacellulin (bTC) Polyclonal Antibody (Mouse)

4-PAA112Mu01
  • EUR 256.80
  • EUR 2394.00
  • EUR 609.60
  • EUR 315.60
  • EUR 240.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC)

Betacellulin, Human

HY-P7005 10ug
EUR 253.2

Betacellulin, human

RC218-23 5ug
EUR 125.26

Bovine Betacellulin

ARU020 20 µg
EUR 303.6

Bovine Betacellulin

ARU100 100 µg
EUR 415.2

Mouse Betacellulin/BTC PicoKine ELISA Kit

EK1193 96 wells
EUR 510
Description: For quantitative detection of mouse BTC in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Betacellulin (bTC) Polyclonal Antibody (Mouse), PE

4-PAA112Mu01-PE
  • EUR 307.20
  • EUR 2493.60
  • EUR 730.80
  • EUR 378.00
  • EUR 214.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with PE.

Betacellulin protein

30R-AB028 20 ug
EUR 327.6
Description: Purified recombinant Human Betacellulin protein

Betacellulin (bTC) Polyclonal Antibody (Mouse), APC

4-PAA112Mu01-APC
  • EUR 355.20
  • EUR 3087.60
  • EUR 884.40
  • EUR 442.80
  • EUR 237.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with APC.

Betacellulin (bTC) Polyclonal Antibody (Mouse), Cy3

4-PAA112Mu01-Cy3
  • EUR 423.60
  • EUR 4066.80
  • EUR 1129.20
  • EUR 541.20
  • EUR 267.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with Cy3.

Betacellulin (bTC) Polyclonal Antibody (Mouse), HRP

4-PAA112Mu01-HRP
  • EUR 327.60
  • EUR 2695.20
  • EUR 786.00
  • EUR 404.40
  • EUR 225.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with HRP.

Betacellulin (BTC) Antibody

abx230883-100ug 100 ug
EUR 577.2

Betacellulin (bTC) Antibody

20-abx175568
  • EUR 1362.00
  • EUR 661.20
  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175569
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175570
  • EUR 1412.40
  • EUR 693.60
  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175571
  • EUR 1545.60
  • EUR 744.00
  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx171411
  • EUR 944.40
  • EUR 493.20
  • 1 mg
  • 200 ug

Betacellulin (BTC) Antibody

20-abx111218
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Betacellulin (bTC) Antibody

20-abx100739
  • EUR 410.40
  • EUR 159.60
  • EUR 1178.40
  • EUR 594.00
  • EUR 343.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody

20-abx100740
  • EUR 477.60
  • EUR 159.60
  • EUR 1328.40
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

BTC Antibody / Betacellulin

F54607-0.08ML 0.08 ml
EUR 140.25
Description: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. [UniProt]

BTC Antibody / Betacellulin

F54607-0.4ML 0.4 ml
EUR 322.15
Description: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. [UniProt]

Betacellulin Antibody / BTC

RQ4417 100 ug
EUR 356.15
Description: Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.

BTC Antibody / Betacellulin

RQ4539 100ug
EUR 356.15
Description: Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

BTC Betacellulin Mouse Recombinant Protein

PROTQ05928 Regular: 20ug
EUR 380.4
Description: BTC Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 80 amino acids and having a molecular mass of 9.0kDa. ;The BTC is purified by proprietary chromatographic techniques.

Betacellulin (bTC) Polyclonal Antibody (Mouse), FITC

4-PAA112Mu01-FITC
  • EUR 307.20
  • EUR 2493.60
  • EUR 730.80
  • EUR 378.00
  • EUR 214.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with FITC.

Mouse Betacellulin/BTC(Beta Cellulin) ELISA Kit

EM0021 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

Betacellulin/BTC ELISA Kit (Mouse) (OKBB00530)

OKBB00530 96 Wells
EUR 606
Description: Description of target: Betacellulin, also known as BTC is a protein that in humans is encoded by the BTC gene. This gene is mapped to 4q13.3. The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. It is the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. This protein is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Betacellulin (bTC) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA112Mu01-APC-Cy7
  • EUR 566.40
  • EUR 6031.20
  • EUR 1624.80
  • EUR 742.80
  • EUR 332.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with APC-Cy7.

Mouse Betacellulin Recombinant Protein Lyophilized

IMSBTCRLY5UG each
EUR 341
Description: Mouse Betacellulin Recombinant Protein Lyophilized

Betacellulin (bTC) Antibody (FITC)

20-abx274036
  • EUR 493.20
  • EUR 276.00
  • EUR 1362.00
  • EUR 661.20
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Mouse Betacellulin Chemiluminescent Immunoassay Kit

IMSBTCKTC each
EUR 545
Description: Mouse Betacellulin Chemiluminescent Immunoassay Kit

Rat Betacellulin ELISA Kit

IRTBTCKT each
EUR 702
Description: Rat Betacellulin ELISA Kit

Betacellulin (bTC) Antibody (Biotin)

20-abx271925
  • EUR 510.00
  • EUR 276.00
  • EUR 1429.20
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody (Biotin)

20-abx272658
  • EUR 460.80
  • EUR 276.00
  • EUR 1262.40
  • EUR 627.60
  • EUR 360.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Polyclonal Antibody (Mouse), Biotinylated

4-PAA112Mu01-Biotin
  • EUR 330.00
  • EUR 2334.00
  • EUR 717.60
  • EUR 394.80
  • EUR 244.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with Biotin.

Recombinant Betacellulin (bTC)

4-RPA112Hu01
  • EUR 550.08
  • EUR 271.20
  • EUR 1732.80
  • EUR 657.60
  • EUR 1195.20
  • EUR 444.00
  • EUR 4152.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Betacellulin expressed in: E.coli

Recombinant Betacellulin (bTC)

4-RPA112Mu01
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Betacellulin expressed in: E.coli

Rat Betacellulin antiserum (Rabbit)

PAAQ1 100 µl
EUR 358.8

Rat Betacellulin (bTC) Protein

20-abx652663
  • EUR 693.60
  • EUR 309.60
  • EUR 2064.00
  • EUR 828.00
  • EUR 510.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cow Betacellulin (bTC) Protein

20-abx652665
  • EUR 777.60
  • EUR 326.40
  • EUR 2397.60
  • EUR 927.60
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Betacellulin ELISA Kit

IHUBTCKT each
EUR 702
Description: Human Betacellulin ELISA Kit

Betacellulin (Human) ELISA Kit

EKA51822-5x96T 5x96T Ask for price

Betacellulin (Human) ELISA Kit

EKA51822-96T 96T
EUR 446.9

Human Betacellulin ELISA KIT

E42EH-268 96T/48T Ask for price

Betacellulin/BTC ELISA Kit| Mouse Beta Cellulin ELISA Kit

EF012837 96 Tests
EUR 826.8

Recombinant Human Betacellulin

7-00223 5µg Ask for price

Recombinant Human Betacellulin

7-00224 20µg Ask for price

Recombinant Human Betacellulin

7-00225 1mg Ask for price

Human Betacellulin (Recombinant)

22060316-1 5 µg
EUR 146.42

Recombinant Human BetaCellulin

HEOPP-0212 5ug Ask for price

Betacellulin, Murine Recombinant

7119-10 each
EUR 235.2

Betacellulin, Murine Recombinant

7119-50 each
EUR 810

Recombinant Bovine Betacellulin

7-00226 5µg Ask for price

Recombinant Bovine Betacellulin

7-00227 20µg Ask for price

Recombinant Bovine Betacellulin

7-00228 1mg Ask for price

Recombinant Bovine Betacellulin

22060014-1 5 µg
EUR 146.42

Recombinant Murine BetaCellulin

MEOPP-0204 5ug Ask for price

Human Betacellulin (bTC) Protein

20-abx065524
  • EUR 777.60
  • EUR 326.40
  • EUR 2331.60
  • EUR 910.80
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Bovine Betacellulin antiserum (Rabbit)

PAAR1 100 µl
EUR 358.8

Rat Betacellulin (BTC) ELISA Kit

abx255590-96tests 96 tests
EUR 801.6

Pig Betacellulin (BTC) ELISA Kit

abx361663-96tests 96 tests
EUR 990

Cow Betacellulin (BTC) ELISA Kit

abx575529-96tests 96 tests
EUR 1093.2

Rat Betacellulin (BTC) ELISA Kit

abx576495-96tests 96 tests
EUR 990

Rat Betacellulin (bTC) ELISA Kit

DLR-bTC-Ra-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates,cell culture supernates or other biological fluids.

Rat Betacellulin (bTC) ELISA Kit

DLR-bTC-Ra-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Rat Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates,cell culture supernates or other biological fluids.

Rat Betacellulin (bTC) ELISA Kit

RDR-bTC-Ra-48Tests 48 Tests
EUR 640.8

Rat Betacellulin (bTC) ELISA Kit

RDR-bTC-Ra-96Tests 96 Tests
EUR 890.4

Rat Betacellulin (bTC) ELISA Kit

RD-bTC-Ra-48T 48T
EUR 443.3
Description: serum, plasma, tissue homogenates, cell lysates,cell culture supernatants and other biological fluids.

Rat Betacellulin (bTC) ELISA Kit

RD-bTC-Ra-96T 96T
EUR 633.3
Description: serum, plasma, tissue homogenates, cell lysates,cell culture supernatants and other biological fluids.

Rat Betacellulin (bTC) ELISA Kit

RD-bTC-Ra-48Tests 48 Tests
EUR 613.2

Rat Betacellulin (bTC) ELISA Kit

RD-bTC-Ra-96Tests 96 Tests
EUR 850.8

Rat Betacellulin (bTC) ELISA Kit

RDR-bTC-Ra-48T 48T
EUR 465.47
Description: serum, plasma, tissue homogenates, cell lysates,cell culture supernatants and other biological fluids.

Rat Betacellulin (bTC) ELISA Kit

RDR-bTC-Ra-96T 96T
EUR 664.97
Description: serum, plasma, tissue homogenates, cell lysates,cell culture supernatants and other biological fluids.

Rat Betacellulin (bTC) ELISA Kit

DL-bTC-Ra 96T
EUR 432
Description: serum, plasma, tissue homogenates, cell lysates,cell culture supernates or other biological fluids.

Rat Betacellulin (bTC) ELISA Kit

DLR-bTC-Ra 96T
EUR 454
Description: serum, plasma, tissue homogenates, cell lysates,cell culture supernates or other biological fluids.

Betacellulin Recombinant Protein

40-192-0005mg 0.005 mg
EUR 311.1
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Betacellulin Recombinant Protein

40-192-002mg 0.02 mg
EUR 437.1
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Betacellulin Recombinant Protein

40-578-0005mg 0.005 mg
EUR 311.1
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Betacellulin Recombinant Protein

40-578-002mg 0.02 mg
EUR 437.1
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Betacellulin Recombinant Protein

91-592 0.05 mg
EUR 651.3
Description: Mouse Betacellulin is a single type I membrane protein which belongs to the EGF family of cytokines. EGF family has many members including EGF, TGF-a, Amphiregulin, HB-EGF, Epiregulin, Tomoregulin and the Neuregulins. Betacellulin is characterised by a six-cysteine consensus motif that forms three intra-molecular disulfide bonds crucial for binding the ErbB receptor family. Betacellulin is expressed in several tissues and tumor cells including kidney, uterus, liver, pancreas and small intestine. Betacellulin binds and activates ErbB-1 and ErbB-4 homodimers. Betacellulin is thought to play a role in the differentiation of pancreatic beta cells.Human and mouse mature BTC protein are 80% identical at the amino acid sequence level. Betacellulin is involved in many biological processes such as stimulating gastrointestinal growth. It is proteolytically processed from a larger membrane-anchored precursor and is a potent mitogen for a wide variety of cell types.

Betacellulin Recombinant Protein

96-830 0.05 mg
EUR 714.3
Description: Probetacellulin can be cleaved into the Betacellulin (BTC) that is a single-pass type I membrane protein containing 1 EGF-like domain. Predominantly expressed in pancreas and small intestine,Betacellulin (BTC) is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. As a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells, Betacellulin (BTC) is also the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Betacellulin (BTC) was originally identified as a growth-promoting factor in mouse pancreatic beta-cell carcinoma cell line and has since been identified in humans. The amino acid sequence of mature mBTC is 82.5%, identical with that of human BTC (hBTC), and both exhibit significant overall similarity with other members of the EGF family.

Human Betacellulin (bTC) CLIA Kit

abx196482-96tests 96 tests
EUR 990

Human Betacellulin (BTC) CLIA Kit

20-abx491043
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Chicken Betacellulin (bTC) Protein

20-abx652666
  • EUR 777.60
  • EUR 326.40
  • EUR 2397.60
  • EUR 927.60
  • EUR 560.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Betacellulin (BTC) ELISA Kit

abx250182-96tests 96 tests
EUR 801.6

Human Betacellulin (BTC) ELISA Kit

abx570040-96tests 96 tests
EUR 801.6

Human Betacellulin, BTC ELISA Kit

DEIA089 10 plates
EUR 3126
Description: This assay is a sandwich Enzyme Linked-Immuno-Sorbent Assay (ELISA). It is developed for quantitative measurement of human BTC in serum, plasma and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu-48T 48T
EUR 574.8
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu-96T 96T
EUR 745.2
Description: A sandwich quantitative ELISA assay kit for detection of Human Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin/BTC ELISA Kit

LF-EK50996 1×96T
EUR 777.6

Human BTC(Betacellulin) ELISA Kit

EH0044 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-48Tests 48 Tests
EUR 600

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-96Tests 96 Tests
EUR 830.4

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-48T 48T
EUR 411.8
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-96T 96T
EUR 588.3
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

SEA112Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

4-SEA112Hu
  • EUR 5188.80
  • EUR 2739.60
  • EUR 703.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Betacellulin (bTC) ELISA Kit

EKN43808-48T 48T
EUR 341.04

Human Betacellulin (bTC) ELISA Kit

EKN43808-5x96T 5x96T
EUR 2314.2

Human Betacellulin (bTC) ELISA Kit

EKN43808-96T 96T
EUR 487.2

Human BTC (Betacellulin) ELISA Kit

EKE60392-5x96T 5x96T
EUR 3124.08

Human BTC (Betacellulin) ELISA Kit

EKE60392-96T 96T
EUR 657.7

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-48Tests 48 Tests
EUR 573.6

Human Betacellulin (bTC) ELISA Kit

RD-bTC-Hu-96Tests 96 Tests
EUR 794.4

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-48T 48T
EUR 432.39
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

RDR-bTC-Hu-96T 96T
EUR 617.72
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DL-bTC-Hu 96T
EUR 402
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin (bTC) ELISA Kit

DLR-bTC-Hu 96T
EUR 422
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Human Betacellulin(BTC)ELISA Kit

YLA3880HU-48T 48T
EUR 435

Human Betacellulin(BTC)ELISA Kit

YLA3880HU-96T 96T
EUR 562.5

Human Betacellulin/BTC ELISA kit

E22-HC017.48 48T
EUR 295

Human Betacellulin/BTC ELISA kit

E22-HC017.96 96T
EUR 395

Human Betacellulin (bTC) ELISA Kit

EKU02697-48T 48T
EUR 500.5

Human Betacellulin (bTC) ELISA Kit

EKU02697-5x96T 5x96T
EUR 3396.25

Human Betacellulin (bTC) ELISA Kit

EKU02697-96T 96T
EUR 715

Rabbit Betacellulin (BTC) ELISA Kit

abx363832-96tests 96 tests
EUR 990

Monkey Betacellulin (BTC) ELISA Kit

abx359865-96tests 96 tests
EUR 990

Human Betacellulin Protein, Fc Tag

BEN-H525x 1mg
EUR 374.5
Description: Human Betacellulin, Fc Tag (BEN-H525x) is expressed from human 293 cells (HEK293). It contains AA Asp 32 - Tyr 111 (Accession # AAH11618).

Bovine Betacellulin (BTC) ELISA Kit

RK06040 96T
EUR 280

Chicken Betacellulin (BTC) ELISA Kit

abx574267-96tests 96 tests
EUR 990

ELISA kit for Rat BTC (Betacellulin)

E-EL-R0101 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Rat BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Rat Betacellulin/BTC

EK5582 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Rat Betacellulin/BTC in samples from serum, plasma, tissue homogenates and other biological fluids.

Betacellulin (bTC) Polyclonal Antibody (Rat)

4-PAA112Ra01
  • EUR 291.60
  • EUR 2940.00
  • EUR 733.20
  • EUR 364.80
  • EUR 254.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC)

CLIA kit for Human BTC (Betacellulin)

E-CL-H0444 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human BTC (Betacellulin)

E-EL-H0570 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

Nori® Human Betacellulin ELISA Kit

GR106276 96-well
EUR 461

ELISA kit for Human bTC (Betacellulin)

ELK1403 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Betacellulin from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Human Betacellulin/BTC

EK5454 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human Betacellulin/BTC in samples from serum, plasma, tissue homogenates and other biological fluids.

Betacellulin (bTC) Polyclonal Antibody (Human)

4-PAA112Hu01
  • EUR 278.40
  • EUR 2742.00
  • EUR 688.80
  • EUR 346.80
  • EUR 249.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Betacellulin (bTC)

Betacellulin (HEK293-expressed), Human

HY-P7328 10ug
EUR 280.8

Human Betacellulin (bTC) Protein (Active)

20-abx655563
  • EUR 1228.80
  • EUR 427.20
  • EUR 4051.20
  • EUR 1479.60
  • EUR 844.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Guinea pig Betacellulin (BTC) ELISA Kit

abx357846-96tests 96 tests
EUR 990

Recombinant Human Betacellulin Protein

PROTP35070-2 20ug
EUR 380.4
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Betacellulin (bTC) Polyclonal Antibody (Rat), PE

4-PAA112Ra01-PE
  • EUR 350.40
  • EUR 3090.00
  • EUR 879.60
  • EUR 438.00
  • EUR 231.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Betacellulin (bTC). This antibody is labeled with PE.

Mouse Betacellulin Recombinant Protein N-6 His Tag Lyophilized

IMSBTCRN6HISLY50UG each
EUR 762
Description: Mouse Betacellulin Recombinant Protein N-6 His Tag Lyophilized

Recombinant Murine Betacellulin Protein

PROTQ05928-1 20ug
EUR 380.4
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
A easy, straightforward and low cost methodology that may be utilized to supply a lot of genetically-modified BM-EPCs was established, which can facilitate the research of GTE-EPC therapeutic efficacy in pig MI mannequin.

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