Exploiting Single-Cell Tools in Gene and Cell Therapy

Exploiting Single-Cell Tools in Gene and Cell Therapy

Single-cell molecular instruments have been developed at an unimaginable tempo over the past 5 years as sequencing prices proceed to drop and quite a few molecular assays have been coupled to sequencing readouts. This fast interval of technological growth has facilitated the delineation of particular person molecular traits together with the genome, transcriptome, epigenome, and proteome of particular person cells, resulting in an unprecedented decision of the molecular networks governing complicated organic techniques.
The immense energy of single-cell molecular screens has been significantly highlighted by work in techniques the place mobile heterogeneity is a key characteristic, similar to stem cell biology, immunology, and tumor cell biology. Single-cell-omics applied sciences have already contributed to the identification of novel illness biomarkers, mobile subsets, therapeutic targets and diagnostics, a lot of which might have been undetectable by bulk sequencing approaches.
Extra not too long ago, efforts to combine single-cell multi-omics with single cell purposeful output and/or bodily location have been difficult however have led to substantial advances. Maybe most excitingly, there are rising alternatives to succeed in past the outline of static mobile states with current advances in modulation of cells by CRISPR expertise, particularly with the event of base editors which tremendously raises the prospect of cell and gene therapies.
On this overview, we offer a short overview of rising single-cell applied sciences and focus on present developments in integrating single-cell molecular screens and performing single-cell multi-omics for medical functions. We additionally focus on how single-cell molecular assays may be usefully mixed with purposeful information to unpick the mechanism of mobile decision-making. Lastly, we mirror upon the introduction of spatial transcriptomics and proteomics, its complementary function with single-cell RNA sequencing (scRNA-seq) and potential software in mobile and gene remedy.

Vector Methods to Actualize B Cell-Based mostly Gene Therapies

Latest developments in genome enhancing and supply techniques have opened new prospects for B cell gene remedy. CRISPR-Cas9 nucleases have been used to introduce transgenes into B cell genomes for subsequent secretion of exogenous therapeutic proteins from plasma cells and to program novel B cell Ag receptor specificities, permitting for the era of fascinating Ab responses that can’t usually be elicited in animal fashions.
Genome modification of B cells or their progenitor, hematopoietic stem cells, might probably substitute Ab or protein alternative therapies that require a number of injections over the long run. Thus far, B cell enhancing utilizing CRISPR-Cas9 has been solely employed in preclinical research, through which cells are edited ex vivo. On this overview, we focus on present B cell engineering efforts and techniques for the eventual protected and economical adoption of modified B cells into the clinic, together with in vivo viral supply of enhancing reagents to B cells.
 Exploiting Single-Cell Tools in Gene and Cell Therapy

Analytics of host cell proteins (HCPs): classes from biopharmaceutical mAb evaluation for Gene remedy merchandise

Analytics for host cell protein (HCP) evaluation of therapeutic monoclonal antibody preparations have developed enormously. We think about how learnings from this could inform HCP evaluation of gene remedy viral vector merchandise. The appliance of mass spectrometry (MS) approaches for evaluation of HCPs in viral vector preparations is being established, though such data stays restricted and is but to be extensively utilized into course of or host cell line growth to cut back HCP quantities or danger.
As these MS approaches, and the information from them, are utilized and develop into accessible, the method understanding created will velocity course of growth exercise. We describe applied sciences which were, or may be, utilized to viral vector HCP evaluation to assist course of growth, scale back HCP quantities, determine crucial HCPs and thus inform danger evaluation and administration primarily based on a information of particular HCPs, in the end delivering protected and efficacious gene remedy merchandise to the clinic.

An optimum non-viral gene switch methodology for genetically modifying porcine bone marrow-derived endothelial progenitor cells for experimental therapeutics

No presently accessible therapy is ready to generate new contractile tissue or considerably enhance cardiac operate after myocardial infarction (MI), a number one reason behind morbidity and mortality worldwide. Though gene transfer-enhanced endothelial progenitor cells (GTE-EPCs) present effectiveness in MI therapy in small animal fashions, no medical trials utilizing GTE-EPCs have been documented. Earlier than the introduction of GTE-EPCs into human trials, gene-transfer-mediated augmentation of EPC operate in animal fashions that mirror the human MI state of affairs ought to be examined.
On this regard, a porcine mannequin is your best option since pigs have cardiac dimension, hemodynamics and coronary anatomy just like that of people. To look at GTE-EPC therapeutic efficacy in pig MI fashions, an environment friendly methodology for gene switch into pig EPCs is required, which nevertheless, has been poorly documented. Pig bone marrow mononuclear cells have been remoted and cultured in EGM-2 medium to acquire bone marrow-derived EPCs (BM-EPCs) that have been characterised by immunostaining and the tube formation assay.
Gene switch was optimized in 6-well plates utilizing a GFP and a VEGF plasmid, and scaled up in T75 flasks. Gene switch effectivity was decided by fluorescence microscopy and stream cytometry. VEGF ranges have been measured by ELISA. Cell proliferation was assayed by the CCK-Eight equipment. (1) BM-EPCs expressed VEGFR2 and eNOS however not CD45 protein, and shaped tube buildings on Matrigel; (2) a number of chemical compounds have been explored with the very best transfection effectivity of 41.4% ± 5.8% achieved utilizing Lipofectamine 3000; (3) the VEGF stage in tradition medium after VEGF transfection was 378 ± 48 ng/106 cells; and (4) BM-EPCs overexpressing VEGF had considerably enhanced proliferation than GFP-transfected EPCs.

anti- Betacellulin antibody

FNab00883 100µg
EUR 606.3
Description: Antibody raised against Betacellulin

Betacellulin Mouse Recombinant

rAP-0362 Inquiry Ask for price

Mouse Betacellulin (bTC) Protein

20-abx065525
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  • 100 ug
  • 10 ug
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  • 200 ug
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Mouse Betacellulin (bTC) Protein

abx065525-100g 100 µg
EUR 612.5

Mouse Betacellulin (bTC) Protein

abx065525-10g 10 µg
EUR 237.5

Mouse Betacellulin (bTC) Protein

abx065525-50g 50 µg
EUR 425

Mouse Betacellulin (BTC) CLIA Kit

20-abx491044
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Mouse Betacellulin (BTC) CLIA Kit

abx196745-100l 100 µl Ask for price

Mouse Betacellulin (BTC) CLIA Kit

abx196745-50l 50 µl
EUR 618.75

Mouse Betacellulin (bTC) ELISA Kit

DLR-bTC-Mu 96T
EUR 370
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

DLR-bTC-Mu-48T 48T
EUR 519.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

DLR-bTC-Mu-96T 96T
EUR 669.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Betacellulin (bTC) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin/BTC ELISA Kit

EK5523 96 tests
EUR 599

Mouse Betacellulin (bTC) ELISA Kit

EKN43809-48T 48T
EUR 294

Mouse Betacellulin (bTC) ELISA Kit

EKN43809-5x96T 5x96T
EUR 1995

Mouse Betacellulin (bTC) ELISA Kit

EKN43809-96T 96T
EUR 420

Mouse Betacellulin (bTC) ELISA Kit

EKU02698-48T 48T
EUR 431.69

Mouse Betacellulin (bTC) ELISA Kit

EKU02698-5x96T 5x96T
EUR 2929.33

Mouse Betacellulin (bTC) ELISA Kit

EKU02698-96T 96T
EUR 616.7

Mouse Betacellulin (bTC) ELISA Kit

DL-bTC-Mu 96T
EUR 353
Description: serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

EK12924 96Т
EUR 768

Mouse Betacellulin (BTC) ELISA Kit

abx574631-96tests 96 tests
EUR 801.6

Mouse Betacellulin (BTC) ELISA Kit

abx253974-96tests 96 tests
EUR 801.6

Mouse Betacellulin (BTC) ELISA Kit

20-abx153708
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  • 10 × 96 tests
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Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-48T 48T
EUR 379.79
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-48Tests 48 Tests
EUR 534

Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-96T 96T
EUR 542.54
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

RDR-bTC-Mu-96Tests 96 Tests
EUR 736.8

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-48T 48T
EUR 361.7
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-48Tests 48 Tests
EUR 511.2

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-96T 96T
EUR 516.7
Description: serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

RD-bTC-Mu-96Tests 96 Tests
EUR 704.4

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-10x96wellstestplate 10x96-wells test plate
EUR 4452.58
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-1x48wellstestplate 1x48-wells test plate
EUR 471.86
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-1x96wellstestplate 1x96-wells test plate
EUR 622.66
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

SEA112Mu-5x96wellstestplate 5x96-wells test plate
EUR 2441.95
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Betacellulin (bTC) in serum, plasma, tissue homogenates, cell lysates and other biological fluids.

Mouse Betacellulin (bTC) ELISA Kit

4-SEA112Mu
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  • 10 plates of 96 wells
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Betacellulin (bTC) in samples from Serum, plasma, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse BTC -Betacellulin- CLIA Kit

E-CL-M0133-24Tests 24 Tests
EUR 180
Description: Sandwich

Mouse BTC -Betacellulin- CLIA Kit

E-CL-M0133-48Tests 48 Tests
EUR 546
Description: Sandwich

Mouse BTC -Betacellulin- CLIA Kit

E-CL-M0133-96Tests 96 Tests
EUR 682
Description: Sandwich

Mouse BTC -Betacellulin- CLIA Kit

E-CL-M0133-96Tests10 96 Tests *10
EUR 6820
Description: Sandwich

Mouse BTC -Betacellulin- CLIA Kit

E-CL-M0133-96Tests5 96 Tests *5
EUR 3410
Description: Sandwich

Mouse bTC(Betacellulin) ELISA Kit

ELK1236-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse bTC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse bTC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse bTC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse bTC in the samples is then determined by comparing the OD of the samples to the standard curve.

Mouse bTC(Betacellulin) ELISA Kit

ELK1236-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse bTC. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse bTC. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Mouse bTC, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Mouse bTC in the samples is then determined by comparing the OD of the samples to the standard curve.

Rat Monoclonal anti-mouse Betacellulin

mAP-0154 100ug
EUR 250

Mouse Betacellulin Recombinant Protein

M10-130 20 µg
EUR 196.35
Description: Betacellulin (BTC or beta-TC) is a member of the EGF family of cytokines which includes EGF, TGFα, amphiregulin, HB-EGF, epiregulin, tomoregulin and the neuregulins. All EGF famiy members are synthesized as type I transmembrane precursor proteins containing one or more EGF-like domains in their extracellular region. BTC, a heparin-binding protein, was originally isolated from the conditioned media of mouse pancreatic beta tumor cells as a 32 kDa glycoprotien. The mouse BTC cDNA encodes a 177 amino acid (aa) residue precursor with a 31 aa signal peptide, an 87 aa residue extracellular region containing one EGF-like domain, a 21 aa transmembrane domain and a 38 aa cytoplasmic domain. Soluble BTC is released from the transmembrane precursor by proteolytic processing. Mouse BTC shares 93% and 79% aa sequence identity with rat and human BTC, respectively. The mouse BTC gene is tightly linked to that of amphiregulin on mouse chromosome 5. BTC is expressed in most tissues including kidney, uterus, liver and pancreas. It is also present in body fluids including serum, milk and colostrum. BTC promotes pancreatic betacell growth and differentiation and is a potent mitogen for retinal pigment epithelial cells, vascular smooth muscle cells and fibroblasts. The effects of BTC is mediated by binding to ErbB1 and ErbB4 homodimers as well as ErbB heterodimers. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Mouse Betacellulin Recombinant Protein

M10-130S 5 µg
EUR 92.4
Description: Betacellulin (BTC or beta-TC) is a member of the EGF family of cytokines which includes EGF, TGFα, amphiregulin, HB-EGF, epiregulin, tomoregulin and the neuregulins. All EGF famiy members are synthesized as type I transmembrane precursor proteins containing one or more EGF-like domains in their extracellular region. BTC, a heparin-binding protein, was originally isolated from the conditioned media of mouse pancreatic beta tumor cells as a 32 kDa glycoprotien. The mouse BTC cDNA encodes a 177 amino acid (aa) residue precursor with a 31 aa signal peptide, an 87 aa residue extracellular region containing one EGF-like domain, a 21 aa transmembrane domain and a 38 aa cytoplasmic domain. Soluble BTC is released from the transmembrane precursor by proteolytic processing. Mouse BTC shares 93% and 79% aa sequence identity with rat and human BTC, respectively. The mouse BTC gene is tightly linked to that of amphiregulin on mouse chromosome 5. BTC is expressed in most tissues including kidney, uterus, liver and pancreas. It is also present in body fluids including serum, milk and colostrum. BTC promotes pancreatic betacell growth and differentiation and is a potent mitogen for retinal pigment epithelial cells, vascular smooth muscle cells and fibroblasts. The effects of BTC is mediated by binding to ErbB1 and ErbB4 homodimers as well as ErbB heterodimers. Recombinant murine Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Anti-Human Betacellulin Antibody

102-P222 100 µg
EUR 245.7
Description: Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor. It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells. Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. Human Betacellulin is initially synthesized as a glycosylated 32.0 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence. Recombinant human Betacellulin is a 9.0 kDa monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.

Anti-Human Betacellulin Antibody

101-M143 100 µg
EUR 399
Description: Betacellulin (BTC) is a new member of the EGF family of cytokines that is comprised of at least ten proteins including EGF, TGF αlpha, amphiregulin, HBEGF, and the various heregulins. All of these cytokines are synthesized as transmembrane precursors and are characterized by the presence of one or more EGF structural units in their extracellular domain. The soluble forms of these cytokines are released by proteolytic cleavage. BTC, a heparin binding protein, was originally isolated from the conditioned media of mouse pancreatic beta tumor cells as a 32 kDa glycoprotein composed of 80 amino acid residues. The cDNA encoding human BTC was cloned from a human breast adenocarcinoma cell line (MCF7) cDNA library. Human and mouse cDNAs encode BTC precursor proteins of 178 and 177 amino acid residues, respectively. At the amino acid sequence level, human BTC precursor protein exhibits 79% identity with that of the mouse BTC precursor. In a mouse cell line transfected with human BTC cDNA, three forms of soluble human BTC have been detected: the glycosylated, intact BTC composed of 80 amino acid residues, a truncated molecule lacking 12 amino acid residues from the amino terminus, and a second truncated molecule lacking 30 amino acid residues from the amino terminus. The biological activities of these BTC forms were shown to be identical. BTC can bind to the EGF receptor and is a potent mitogen for Balb/c 3T3 fibroblasts, retinal pigment epithelial cells and vascular smooth muscle cells.

Anti-Human Betacellulin Antibody

101-M230 100 µg
EUR 399
Description: Betacellulin (BTC) is a new member of the EGF family of cytokines that is comprised of at least ten proteins including EGF, TGF αlpha, amphiregulin, HBEGF, and the various heregulins. All of these cytokines are synthesized as transmembrane precursors and are characterized by the presence of one or more EGF structural units in their extracellular domain. The soluble forms of these cytokines are released by proteolytic cleavage. BTC, a heparin binding protein, was originally isolated from the conditioned media of mouse pancreatic beta tumor cells as a 32 kDa glycoprotein composed of 80 amino acid residues. The cDNA encoding human BTC was cloned from a human breast adenocarcinoma cell line (MCF7) cDNA library. Human and mouse cDNAs encode BTC precursor proteins of 178 and 177 amino acid residues, respectively. At the amino acid sequence level, human BTC precursor protein exhibits 79% identity with that of the mouse BTC precursor. In a mouse cell line transfected with human BTC cDNA, three forms of soluble human BTC have been detected: the glycosylated, intact BTC composed of 80 amino acid residues, a truncated molecule lacking 12 amino acid residues from the amino terminus, and a second truncated molecule lacking 30 amino acid residues from the amino terminus. The biological activities of these BTC forms were shown to be identical. BTC can bind to the EGF receptor and is a potent mitogen for Balb/c 3T3 fibroblasts, retinal pigment epithelial cells and vascular smooth muscle cells.

Betacellulin (HEK293-expressed), Mouse

HY-P7142 50ug
EUR 639.6

CLIA kit for Mouse BTC (Betacellulin)

E-CL-M0133 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Mouse BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

Betacellulin (bTC) Polyclonal Antibody (Mouse)

4-PAA112Mu01
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  • 100ul
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Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC)

ELISA kit for Mouse BTC (Betacellulin)

E-EL-M0181 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Mouse BTC (Betacellulin) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Mouse bTC (Betacellulin)

ELK1236 1 plate of 96 wells
EUR 446.4
Description: A sandwich ELISA kit for detection of Betacellulin from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Betacellulin antibody

70R-BR013 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal Betacellulin antibody

Betacellulin (bTC) Polyclonal Antibody (Mouse), PE

4-PAA112Mu01-PE
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  • 100ul
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  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with PE.

Mouse Betacellulin/BTC PicoKine ELISA Kit

EK1193 96 wells
EUR 510
Description: For quantitative detection of mouse BTC in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Betacellulin, human

RC218-23 5ug
EUR 125.26

Betacellulin, Human

HY-P7005 10ug
EUR 253.2

Betacellulin (bTC) Polyclonal Antibody (Mouse), APC

4-PAA112Mu01-APC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with APC.

Betacellulin (bTC) Polyclonal Antibody (Mouse), Cy3

4-PAA112Mu01-Cy3
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with Cy3.

Betacellulin (bTC) Polyclonal Antibody (Mouse), HRP

4-PAA112Mu01-HRP
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with HRP.

Bovine Betacellulin

ARU020 20 µg
EUR 303.6

Bovine Betacellulin

ARU100 100 µg
EUR 415.2

Betacellulin (bTC) Polyclonal Antibody (Mouse), FITC

4-PAA112Mu01-FITC
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with FITC.

BTC Betacellulin Mouse Recombinant Protein

PROTQ05928 Regular: 20ug
EUR 380.4
Description: BTC Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 80 amino acids and having a molecular mass of 9.0kDa. ;The BTC is purified by proprietary chromatographic techniques.

Recombinant Mouse Betacellulin/BTC (N-6His)

AP75333 1mg
EUR 3209

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse Betacellulin/BTC (N-6His)

C747-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Betacellulin protein

30R-AB028 20 ug
EUR 312
Description: Purified recombinant Human Betacellulin protein

Mouse Betacellulin/BTC(Beta Cellulin) ELISA Kit

EM0021 96T
EUR 681.12
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Mus ;Sensitivity: 4.688pg/ml

BTC Antibody / Betacellulin

F54607-0.08ML 0.08 ml
EUR 140.25
Description: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. [UniProt]

BTC Antibody / Betacellulin

F54607-0.4ML 0.4 ml
EUR 322.15
Description: Growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. Potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells. [UniProt]

Betacellulin (bTC) Antibody

20-abx100739
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody

20-abx100740
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
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Betacellulin (bTC) Antibody

20-abx175568
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  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175569
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  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175570
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  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx175571
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  • 1 mg
  • 200 ug

Betacellulin (bTC) Antibody

20-abx171411
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  • 1 mg
  • 200 ug

Betacellulin (BTC) Antibody

abx230883-100ug 100 ug
EUR 577.2

Betacellulin (BTC) Antibody

20-abx111218
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  • 150 ul
  • 50 ul

Betacellulin Antibody / BTC

RQ4417 100 ug
EUR 356.15
Description: Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.

BTC Antibody / Betacellulin

RQ4539 100ug
EUR 356.15
Description: Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.

Betacellulin (BTC) Antibody

abx230883-100g 100 µg
EUR 350

Betacellulin (BTC) Antibody

abx111218-100l 100 µl
EUR 612.5

Betacellulin (bTC) Antibody

abx100739-100l 100 µl
EUR 237.5

Betacellulin (bTC) Antibody

abx100739-1ml 1 ml
EUR 575

Betacellulin (bTC) Antibody

abx100739-200l 200 µl
EUR 287.5

Betacellulin (bTC) Antibody

abx100740-100l 100 µl
EUR 250

Betacellulin (bTC) Antibody

abx100740-1ml 1 ml
EUR 675

Betacellulin (bTC) Antibody

abx100740-200l 200 µl
EUR 312.5

Betacellulin (bTC) Antibody

abx175570-1096tests 10 × 96 tests Ask for price

Betacellulin (bTC) Antibody

abx175570-596tests 5 × 96 tests Ask for price

Betacellulin (bTC) Antibody

abx175570-96tests 96 tests
EUR 725

Betacellulin (bTC) Antibody

abx171411-100l 100 µl
EUR 712.5

Betacellulin (bTC) Antibody

abx171411-1ml 1 ml Ask for price

Betacellulin (bTC) Antibody

abx171411-200l 200 µl Ask for price

Betacellulin/BTC ELISA Kit (Mouse) (OKBB00530)

OKBB00530 96 Wells
EUR 606
Description: Description of target: Betacellulin, also known as BTC is a protein that in humans is encoded by the BTC gene. This gene is mapped to 4q13.3. The protein encoded by this gene is a member of the EGF family of growth factors. It is synthesized primarily as a transmembrane precursor, which is then processed to mature molecule by proteolytic events. This protein is a ligand for the EGF receptor. It is the growth factor that binds to EGFR, ERBB4 and other EGF receptor family members. This protein is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.;Species reactivity: Mouse;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Mouse Monoclonal ant-Human Betacellulin (BTC)

hAP-0110 100ug
EUR 250

Mouse Monoclonal ant-Human Betacellulin (BTC)

hAP-0110A 100ug
EUR 250

Betacellulin (bTC) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA112Mu01-APC-Cy7
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with APC-Cy7.

Mouse Betacellulin Flow Cytometry Assay - Group 3

MX78121 96 Tests
EUR 270

Mouse Betacellulin Recombinant Protein Lyophilized

IMSBTCRLY5UG each
EUR 341
Description: Mouse Betacellulin Recombinant Protein Lyophilized

Active Betacellulin (bTC)

RPU59143-100ug 100ug
EUR 1013.8

Active Betacellulin (bTC)

RPU59143-1mg 1mg
EUR 4212

Active Betacellulin (bTC)

RPU59143-50ug 50ug
EUR 673.2

Mouse Betacellulin Chemiluminescent Immunoassay Kit

IMSBTCKTC each
EUR 545
Description: Mouse Betacellulin Chemiluminescent Immunoassay Kit

Betacellulin (bTC) Antibody (FITC)

20-abx274036
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody (FITC)

abx274036-05ml 0.5 ml
EUR 362.5

Recombinant Mouse Betacellulin/BTC Protein (His Tag)

PKSM040967-10ug 10ug
EUR 129
Description: Mouse

Recombinant Mouse Betacellulin/BTC Protein (His Tag)

PKSM040967-50ug 50ug
EUR 375
Description: Mouse

Betacellulin (bTC) Polyclonal Antibody (Mouse), Biotinylated

4-PAA112Mu01-Biotin
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
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Description: A Rabbit polyclonal antibody against Mouse Betacellulin (bTC). This antibody is labeled with Biotin.

Sheep Polyclonal anti-human Betacellulin (BTC)

hAP-5047 50ug
EUR 400

Sheep Polyclonal anti-Human Betacellulin (BTC)

hAP-5649 50ug
EUR 400

Betacellulin (bTC) Antibody (Biotin)

20-abx271925
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody (Biotin)

20-abx272658
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Betacellulin (bTC) Antibody (Biotin)

abx271925-1ml 1 ml
EUR 737.5

Betacellulin (bTC) Antibody (Biotin)

abx271925-200l 200 µl
EUR 337.5

Betacellulin (bTC) Antibody (Biotin)

abx272658-100l 100 µl
EUR 300

Betacellulin (bTC) Antibody (Biotin)

abx272658-1ml 1 ml Ask for price

Betacellulin (bTC) Antibody (Biotin)

abx272658-200l 200 µl
EUR 637.5

Rat Betacellulin ELISA Kit

IRTBTCKT each
EUR 702
Description: Rat Betacellulin ELISA Kit

Rat Betacellulin antiserum (Rabbit)

PAAQ1 100 µl
EUR 358.8

Betacellulin/BTC ELISA Kit| Mouse Beta Cellulin ELISA Kit

EF012837 96 Tests
EUR 826.8

Recombinant Betacellulin (bTC)

RPU40447-100ug 100ug
EUR 492.8

Recombinant Betacellulin (bTC)

RPU40447-1mg 1mg
EUR 2184

Recombinant Betacellulin (bTC)

RPU40447-50ug 50ug
EUR 396

Recombinant Betacellulin (bTC)

RPU40448-100ug 100ug
EUR 591.8

Recombinant Betacellulin (bTC)

RPU40448-1mg 1mg
EUR 2620.8

Recombinant Betacellulin (bTC)

RPU40448-50ug 50ug
EUR 475.2

Recombinant Betacellulin (bTC)

RPU57900-100ug 100ug
EUR 521.7

Recombinant Betacellulin (bTC)

RPU57900-1mg 1mg
EUR 2421.1

Recombinant Betacellulin (bTC)

RPU57900-50ug 50ug
EUR 426.8

Recombinant Betacellulin (bTC)

RPU56114-100ug 100ug
EUR 554.4

Recombinant Betacellulin (bTC)

RPU56114-1mg 1mg
EUR 2184

Recombinant Betacellulin (bTC)

RPU56114-50ug 50ug
EUR 336

Recombinant Betacellulin (bTC)

RPA112Hu01 10ug
EUR 160

Recombinant Betacellulin (bTC)

4-RPA112Hu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Betacellulin expressed in: E.coli

Recombinant Betacellulin (bTC)

RPA112Mu01 10ug
EUR 192

Recombinant Betacellulin (bTC)

4-RPA112Mu01
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  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Betacellulin expressed in: E.coli

Recombinant Betacellulin (bTC)

RPA112Ra01 10ug
EUR 140

Betacellulin (Human) ELISA Kit

EKA51822-5x96T 5x96T Ask for price

Betacellulin (Human) ELISA Kit

EKA51822-96T 96T
EUR 446.9

Human Betacellulin ELISA KIT

E42EH-268 96T/48T Ask for price

Rat Betacellulin (bTC) Protein

20-abx652663
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Cow Betacellulin (bTC) Protein

20-abx652665
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  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Betacellulin ELISA Kit

GWB-SKR006 96 Tests Ask for price

Human Betacellulin ELISA Kit

IHUBTCKT each
EUR 702
Description: Human Betacellulin ELISA Kit

Rat Betacellulin (bTC) Protein

abx652663-5mg 5 mg
EUR 337.5

Cow Betacellulin (bTC) Protein

abx652665-5mg 5 mg
EUR 5300

Recombinant Human Betacellulin

7-00223 5µg Ask for price

Recombinant Human Betacellulin

7-00224 20µg Ask for price

Recombinant Human Betacellulin

7-00225 1mg Ask for price

Human Betacellulin (Recombinant)

22060316-1 5 µg
EUR 146.42

Recombinant Human Betacellulin

AP60110 100ug
EUR 896

Recombinant Human BetaCellulin

HEOPP-0212 5ug Ask for price

Recombinant Human Betacellulin

cyt-330-1mg 1mg
EUR 2700

Recombinant Human Betacellulin

cyt-330-20g 20µg
EUR 145

Recombinant Human Betacellulin

cyt-330-5g 5µg
EUR 60

Betacellulin Human Recombinant

rAP-0363 Inquiry Ask for price

Betacellulin (bTC) Polyclonal Antibody

CAU28583-100ul 100ul
EUR 182.4

Betacellulin (bTC) Polyclonal Antibody

CAU28583-200ul 200ul
EUR 228.5

Betacellulin (bTC) Polyclonal Antibody

CAU28584-100ul 100ul
EUR 212.2

Betacellulin (bTC) Polyclonal Antibody

CAU28584-200ul 200ul
EUR 265.4

Betacellulin (bTC) Polyclonal Antibody

CAU30301-100ul 100ul
EUR 229.4

Betacellulin (bTC) Polyclonal Antibody

CAU30301-200ul 200ul
EUR 287.3

Bovine Betacellulin antiserum (Rabbit)

PAAR1 100 µl
EUR 358.8

Anti-Human Betacellulin Rabbit Polyclonal Antibody

TA328270 100 µg Ask for price

Recombinant Bovine Betacellulin

7-00226 5µg Ask for price

Recombinant Bovine Betacellulin

7-00227 20µg Ask for price

Recombinant Bovine Betacellulin

7-00228 1mg Ask for price
A easy, straightforward and low cost methodology that may be utilized to supply a lot of genetically-modified BM-EPCs was established, which can facilitate the research of GTE-EPC therapeutic efficacy in pig MI mannequin.

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