Regardless of the unequivocal success of hematopoietic stem and progenitor cell gene remedy, limitations nonetheless exist together with genotoxicity and variegation/silencing of transgene expression. A category of DNA regulatory components often known as chromatin insulators (CI) can mitigate each, vector transcriptional silencing (barrier CIs) and vector-induced genotoxicity (enhancer-blocking CIs) and have been proposed as genetic […]
